TPOXX Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx a TPOXX coupon provider?

NiceRx does not provide TPOXX coupons, discount cards, or copay cards. We do not offer printable TPOXX manufacturer coupons, TPOXX discounts, rebates, TPOXX savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your TPOXX medication with NiceRx.

TPOXX patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

Can NiceRx help me get TPOXX cheaper if I have insurance?

How much does TPOXX cost without insurance?

TPOXX prices without insurance will vary by retailer.

How much does TPOXX cost with insurance?

Your individual healthcare plan will determine the copay of TPOXX with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is TPOXX?

TPOXX is an FDA-approved (U.S. Food and Drug Administration) medication manufactured by SIGA Technologies Inc. TPOXX was developed by the U.S. Department of Health and Human Services’ Biomedical Advanced Research and Development Authority (BARDA).

TPOXX is an antiviral drug with activity against orthopoxviruses such as smallpox and the monkeypox virus. However, its use for monkeypox is not approved by the FDA. Therefore, the CDC holds a protocol that allows for the use of tecovirimat for the treatment of non-variola orthopoxvirus infections, including monkeypox, in adults and children of all ages.

TPOXX is an inhibitor of the orthopoxvirus protein and is used for the treatment of human smallpox disease in adults and pediatric patients weighing at least 3 kg. The effectiveness of TPOXX may be reduced in immunocompromised patients based on animal studies showing reduced effectiveness in immunocompromised animal models.

What doses of TPOXX are available?

TPOXX is available as a capsule and injection formulation, in the following doses: 200 mg, and a single-dose vial containing 200 mg in 20 mL.

Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

TPOXX active ingredients

TPOXX contains tecovirimat as the active ingredient. TPOXX prevents the spread of the variola virus by blocking the production of a secondary viral envelope. Without this envelope, viral particles remain inside the cell in which they were made and cannot spread to and infect other cells.

TPOXX side effects

The most common side effects of TPOXX in clinical trials compared to placebo include:

  • Headache
  • Nausea
  • Abdominal pain
  • Vomiting
  • Administration site reactions

In rare instances, TPOXX can cause more serious adverse effects. These can include:

  • Hypoglycemia

Your doctor will assess the benefits of using TPOXX against your risk of adverse events. Patients are encouraged to report negative side effects or adverse reactions of TPOXX to the FDA. Visit, or call 1-800-FDA-1088.

TPOXX drug interactions

TPOXX can interact with other medications. These include:

  • Significant interactions in healthy adults with co-administration of repaglinide and midazolam

This list is not exhaustive and other prescription drugs may interact with TPOXX.

TPOXX contraindications

You should not use TPOXX if you:

  • Are allergic to the active ingredient tecovirimat
  • Are allergic to any of the other ingredients such as colloidal silicon dioxide, hydroxypropyl methylcellulose, lactose monohydrate, microcrystalline cellulose, or sodium lauryl sulfate
  • Have severe renal impairment
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using TPOXX if you:

  • Are taking any of the medications that could interact with TPOXX
  • Have diabetes
  • Have kidney problems
  • Are breastfeeding or are planning to breastfeed

TPOXX generic

TPOXX is the trademark brand name for tecovirimat manufactured by SIGA Technologies Inc. A generic version of tecovirimat is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find TPOXX savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.