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Trexall Patient assistance program

Is your Trexall medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Trexall medication with our help.

Get started today
  • Secure: Your personal and medical information is safe with us
  • Convenient: We manage the whole process and we’re here to assist you
  • Ongoing refills: We request your medication refills on your behalf
  • Secure: Your personal and medical information is safe with us
  • Convenient: We manage the whole process and we’re here to assist you
  • Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

An introduction to NiceRx

Play video (01:52)
  • An introduction to NiceRx
    (01:52)
  • Next steps after qualifying
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  • Uploading documents and billing
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  • SSN & billing information
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  • Medication delivery time
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How it works

  • Apply Online

    Get started by filling out the online enrollment application to find out if you are eligible.

  • Qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are qualified. The pharmaceutical company provides your medication for free and you only pay our service fee.

  • Upload Documents

    You may be required to submit further information and documents required by the pharmaceutical company which can be securely uploaded online.

  • Application Created

    Your application is created and sent to your doctor for signature. At this stage, you will be billed $49 and will not be billed again until you receive your first medication delivery.

  • Receive Medication

    Your application is sent to the pharmaceutical company. You will be billed again once you receive your medication. We handle the entire ordering process including requesting ongoing refills.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Trexall cost savings if eligible

The Trexall patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Trexall, regardless of the retail price.

Am I eligible for the Trexall patient assistance program?

To find out if you are eligible for Trexall assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Trexall patient assistance program?

Our application process aims to make it as easy as possible to apply for the Trexall patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Trexall.

NiceRx will review your application and determine whether you may be eligible for Trexall assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Trexall patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period, we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Trexall.

Is NiceRx a Trexall coupon provider?

NiceRx is a service provider that helps eligible individuals access the Trexall patient assistance program. We do not offer trial offers or free Trexall samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Trexall coupons, discount cards, or Trexall copay cards.

Can NiceRx help me get Trexall cheaper if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Trexall medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Trexall cost without insurance?

Trexall prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Trexall oral tablets 5 mg typically cost $560 for 30 tablets.

How much does Trexall cost with insurance?

The copay for Trexall will vary by the terms of your healthcare plan. To find out what you might need to pay for Trexall with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Trexall?

Trexall is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Teva Pharmaceuticals USA, Inc. It is an antimetabolite used to treat gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole, acute lymphocytic leukemia, meningeal leukemia, breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides, lung cancer, advanced non-Hodgkin’s lymphomas, and osteosarcoma. It is also indicated for the treatment of severe psoriasis or rheumatoid arthritis that has not been adequately treated with other therapy, and may also be used for the treatment of juvenile rheumatoid arthritis.

What doses of Trexall are available?

Trexall is available in tablet form, in the following doses: 5 mg.

Methotrexate can lower levels of folate in your body. Take folic acid supplements with methotrexate to prevent a folate deficiency. Folate deficiency can lead to symptoms such as tiredness, muscle weakness, mouth ulcers, and neurological symptoms.

Please read the drug information provided with your medicine and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Trexall active ingredients

Trexall contains methotrexate as the active ingredient.

Trexall side effects

The most common side effects of Trexall in clinical trials include:

  • Nausea, stomach pain, dyspepsia, diarrhea, vomiting
  • Stomatitis/mouth sores, rash, nasopharyngitis, sore throat
  • Hair loss
  • Abnormalities in liver function tests, as detected by blood tests
  • Headache, dizziness, drowsiness
  • Bronchitis
  • Thrombocytopenia, leucopenia, pancytopenia
  • Photosensitivity, and burning of skin lesions

In rare instances, Trexall can cause more serious side effects. These can include:

  • Bone marrow, liver, lung, skin, and kidney toxicities
  • Fetal death and/or birth defects
  • Unexpectedly severe (sometimes fatal) bone marrow suppression, aplastic anemia, and gastrointestinal toxicity when given with some nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Hepatotoxicity, fibrosis, and cirrhosis
  • Methotrexate-induced lung disease
  • Interstitial pneumonitis at any time during therapy and has been reported at low doses
  • Pulmonary symptoms – dry cough may require interruption of treatment and investigation
  • Diarrhea, ulcerative stomatitis, hemorrhagic enteritis, and death from intestinal perforation
  • Severe, occasionally fatal, skin reactions
  • Potentially fatal opportunistic infections

Stop taking Trexall and call your doctor if you get diarrhea, mouth sores, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.

Your doctor will assess the benefits of using Trexall against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Trexall to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Trexall drug interactions

Trexall can interact with other medications. These include:

  • Retinoids such as isotretinoin
  • NSAIDs – ibuprofen, naproxen
  • Steroids – prednisone
  • Proton pump inhibitors – esomeprazole, lansoprazole, omeprazole, pantoprazole
  • Other drugs that can cause liver problems such as azathioprine, sulfasalazine
  • Penicillins
  • Phenytoin
  • Probenecid
  • Sulfa medications
  • Tetracyclines
  • Theophylline
  • Certain vaccinations

This list is not exhaustive and other prescription drugs may interact with Trexall. Tell your healthcare provider about all of the medicines you take, including prescription, over-the-counter medicines, vitamins, and herbal supplements.

Trexall contraindications

You should not use Trexall if you:

  • Have known hypersensitivity to the active ingredient methotrexate
  • Are allergic to any of the other ingredients in Trexall
  • Suffer from alcoholism
  • Have liver disease
  • Have low blood cell counts
  • Have a weak immune system
  • Are pregnant or are planning to become pregnant – Women must use birth control while taking Trexall and for some time after the last dose

Talk to your doctor before using Trexall if you:

  • Are taking any of the medications that could interact with Trexall
  • Have anemia, leukopenia, or thrombocytopenia (low platelet blood level)
  • Have renal impairment
  • Have pleural effusion
  • Have diabetes
  • Have ulcerative colitis
  • Are breastfeeding or are planning to breastfeed

Trexall generic

Trexall is the trademark brand name for methotrexate manufactured by Teva Pharmaceuticals USA, Inc. A generic version of methotrexate is available. Generic drugs are generally cheaper than brand name drugs, but you can still find Trexall savings through NiceRx.

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking down the different programs and filling out all the required paperwork for each program.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.