Trexall Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx a Trexall coupon provider?

NiceRx is a service provider that helps eligible individuals access patient assistance program. We do not offer trial offers or free Trexall samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Trexall coupons, discount cards, or Trexall copay cards.

Trexall patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

How much does Trexall cost without insurance?

Trexall prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Trexall oral tablets 5 mg typically cost $560 for 30 tablets.

How much does Trexall cost with insurance?

The copay for Trexall will vary by the terms of your healthcare plan. To find out what you might need to pay for Trexall with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Trexall?

Trexall is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Teva Pharmaceuticals USA, Inc. It is an antimetabolite used to treat gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole, acute lymphocytic leukemia, meningeal leukemia, breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides, lung cancer, advanced non-Hodgkin’s lymphomas, and osteosarcoma. It is also indicated for the treatment of severe psoriasis or rheumatoid arthritis that has not been adequately treated with other therapy, and may also be used for the treatment of juvenile rheumatoid arthritis.

What doses of Trexall are available?

Trexall is available in tablet form, in the following doses: 5 mg.

Methotrexate can lower levels of folate in your body. Take folic acid supplements with methotrexate to prevent a folate deficiency. Folate deficiency can lead to symptoms such as tiredness, muscle weakness, mouth ulcers, and neurological symptoms.

Please read the drug information provided with your medicine and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Trexall active ingredients

Trexall contains methotrexate as the active ingredient.

Trexall side effects

The most common side effects of Trexall in clinical trials include:

  • Nausea, stomach pain, dyspepsia, diarrhea, vomiting
  • Stomatitis/mouth sores, rash, nasopharyngitis, sore throat
  • Hair loss
  • Abnormalities in liver function tests, as detected by blood tests
  • Headache, dizziness, drowsiness
  • Bronchitis
  • Thrombocytopenia, leucopenia, pancytopenia
  • Photosensitivity, and burning of skin lesions

In rare instances, Trexall can cause more serious side effects. These can include:

  • Bone marrow, liver, lung, skin, and kidney toxicities
  • Fetal death and/or birth defects
  • Unexpectedly severe (sometimes fatal) bone marrow suppression, aplastic anemia, and gastrointestinal toxicity when given with some nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Hepatotoxicity, fibrosis, and cirrhosis
  • Methotrexate-induced lung disease
  • Interstitial pneumonitis at any time during therapy and has been reported at low doses
  • Pulmonary symptoms – dry cough may require interruption of treatment and investigation
  • Diarrhea, ulcerative stomatitis, hemorrhagic enteritis, and death from intestinal perforation
  • Severe, occasionally fatal, skin reactions
  • Potentially fatal opportunistic infections

Stop taking Trexall and call your doctor if you get diarrhea, mouth sores, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.

Your doctor will assess the benefits of using Trexall against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Trexall to the FDA. Visit, or call 1-800-FDA-1088.

Trexall drug interactions

Trexall can interact with other medications. These include:

  • Retinoids such as isotretinoin
  • NSAIDs – ibuprofen, naproxen
  • Steroids – prednisone
  • Proton pump inhibitors – esomeprazole, lansoprazole, omeprazole, pantoprazole
  • Other drugs that can cause liver problems such as azathioprine, sulfasalazine
  • Penicillins
  • Phenytoin
  • Probenecid
  • Sulfa medications
  • Tetracyclines
  • Theophylline
  • Certain vaccinations

This list is not exhaustive and other prescription drugs may interact with Trexall. Tell your healthcare provider about all of the medicines you take, including prescription, over-the-counter medicines, vitamins, and herbal supplements.

Trexall contraindications

You should not use Trexall if you:

  • Have known hypersensitivity to the active ingredient methotrexate
  • Are allergic to any of the other ingredients in Trexall
  • Suffer from alcoholism
  • Have liver disease
  • Have low blood cell counts
  • Have a weak immune system
  • Are pregnant or are planning to become pregnant – Women must use birth control while taking Trexall and for some time after the last dose

Talk to your doctor before using Trexall if you:

  • Are taking any of the medications that could interact with Trexall
  • Have anemia, leukopenia, or thrombocytopenia (low platelet blood level)
  • Have renal impairment
  • Have pleural effusion
  • Have diabetes
  • Have ulcerative colitis
  • Are breastfeeding or are planning to breastfeed

Trexall generic

Trexall is the trademark brand name for methotrexate manufactured by Teva Pharmaceuticals USA, Inc. A generic version of methotrexate is available. Generic drugs are generally cheaper than brand name drugs, but you can still find Trexall savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.