Trikafta Coupon & Prices

Is your Trikafta medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Trikafta medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

How it works

  • Enroll online

    Get started by filling out the online enrollment application to find out if you are eligible for assistance.

  • Pre-qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.

  • Submit documents

    We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.

  • Receive medication

    Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Trikafta cost savings if eligible

If you are eligible to receive your Trikafta prescription through the patient assistance program, your medication will be free. We charge a flat monthly service fee of $49 per medication to cover the cost of our services.

Am I eligible for Trikafta patient assistance?

To be eligible for the Trikafta patient assistance program, you will need to meet specific eligibility criteria set by the pharmaceutical company. At NiceRx, we review each Trikafta enrollment application individually. The main factors considered are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Trikafta patient assistance program?

Applying for the Trikafta patient assistance program through NiceRx is simple. Begin by completing the enrollment application on our website. We will ask for details about your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers that supply your medication. We may be able to help you access patient assistance for other medications as well as Trikafta, so please tell us about any medications that you have been prescribed.

If we determine that you may be eligible for Trikafta assistance, we will handle the full enrollment process on your behalf. We will work with your healthcare provider to prepare and submit all the documents required for you to enroll. If you are successfully enrolled in the Trikafta patient assistance program, we will also request your Trikafta medication refills on your behalf for up to 1 year. At the end of your enrollment period, we will contact you for updated details and seek to re-enroll you in the program.

Is NiceRx a Trikafta coupons provider?

NiceRx does not provide Trikafta coupons, discount cards, or copay cards. We do not offer printable Trikafta manufacturer coupons, Trikafta discounts, rebates, Trikafta savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Trikafta medication with NiceRx.

Can NiceRx help me get Trikafta if I have insurance?

NiceRx may be able to help you access Trikafta patient assistance if:

  • You have a high copay or coinsurance responsibility for Trikafta
  • Your insurance company will not pay for your Trikafta prescription
  • You do not have insurance

Complete your enrollment application online to find out more.

How much does Trikafta cost without insurance?

Trikafta prices without insurance will vary by retailer. As a guide, Trikafta oral tablet (50 mg-37.5 mg-25 mg and ivacaftor 75 mg) will typically cost around $26,200 for 84 tablets.

How much does Trikafta cost with insurance?

Your individual healthcare plan will determine the copay of Trikafta with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Trikafta?

Trikafta (elexacaftor/tezacaftor/ivacaftor) is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Vertex Pharmaceuticals Incorporated.

Trikafta is a triple combination therapy of ivacaftor, a CFTR potentiator, tezacaftor, and elexacaftor indicated for the treatment of cystic fibrosis, CF patients aged 12 years and older who have at least one F508del mutation in the CFTR gene. If the patient’s genotype is unknown, an FDA-cleared CF mutation test should be used to confirm the presence of at least one F508del mutation.

Trikafta targets the defective CFTR protein. It helps the protein made by the CFTR gene mutation function more effectively. Similar to other CFTR modulators, Trikafta is not expected to improve lung function or pulmonary symptoms following a lung transplant. It is not known if Trikafta is safe and effective in children under 6 years of age.

What doses of Trikafta are available?

Trikafta is available in tablet form, in the following doses: fixed-dose combination containing elexacaftor 100 mg, tezacaftor 50 mg, and ivacaftor 75 mg. Co-packaged with ivacaftor tablets 150 mg.

Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Trikafta active ingredients

Trikafta contains elexacaftor, tezacaftor, and ivacaftor as the active ingredients.

Trikafta side effects

The most common side effects of Trikafta in clinical trials compared to placebo include:

  • Headache
  • Upper respiratory tract infection
  • Abdominal pain, diarrhea
  • Rash
  • Nasal congestion, rhinorrhea, rhinitis, sinusitis
  • Influenza

In rare instances, Trikafta can cause more serious adverse effects. These can include:

  • Elevated liver function tests – alanine aminotransferase increased, blood creatine phosphokinase increased, aspartate aminotransferase increased, blood bilirubin increased
  • Cataracts – non-congenital lens opacities/cataracts have been reported in pediatric patients treated with ivacaftor-containing regimens. Baseline and follow-up examinations are recommended in pediatric patients

Your doctor will assess the benefits of using Trikafta against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Trikafta to the FDA. Visit, or call 1-800-FDA-1088.

Trikafta drug interactions

Trikafta can interact with other medications. These include:

  • Strong CYP3A inducers
  • Strong or moderate CYP3A inhibitors – ketoconazole, itraconazole, posaconazole, voriconazole, telithromycin, clarithromycin, fluconazole, erythromycin
  • Grapefruit – avoid food or drink containing grapefruit
  • Rifabutin or rifampin
  • St. John’s wort
  • Treatments for seizures – carbamazepine, phenobarbital, or phenytoin

This list is not exhaustive and other prescription drugs may interact with Trikafta. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Trikafta contraindications

You should not use Trikafta if you:

  • Are allergic to the active ingredient elexacaftor, ivacaftor, and tezacaftor
  • Are allergic to any of the other ingredients in Trikafta

Talk to your doctor about your medical condition before using Trikafta if you:

  • Are taking any of the medications that could interact with Trikafta
  • Have liver disease
  • Have kidney disease
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Trikafta generic

Trikafta is the trademark brand name for elexacaftor, ivacaftor, and tezacaftor manufactured by Vertex Pharmaceuticals Incorporated. A generic version of elexacaftor, ivacaftor, and tezacaftor are not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Trikafta savings through NiceRx.

Related medications

Related conditions

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.