Trudhesa Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Trudhesa cost savings if eligible

With our assistance, you could access the Trudhesa patient assistance program and obtain your medication for free. We only charge a flat monthly fee of $49 per medication for our services.

Am I eligible for Trudhesa patient assistance?

We review each Trudhesa enrollment application individually to determine if you are eligible. Each assistance program has its own eligibility criteria and the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Trudhesa patient assistance program?

Our process makes it as easy as possible to apply for the Trudhesa patient assistance program. Begin by completing the enrollment application form on our website. Tell us about any medications that you are taking, including Trudhesa, your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers who will supply the medication, so it is important to make sure this information is accurate and up to date.

We will review the information that you have provided to determine whether you are eligible for patient assistance. If we can pre-qualify you for assistance, NiceRx will handle the full enrollment process on your behalf. If you are approved by the pharmaceutical company, you will typically start receiving your medication in 6 – 8 weeks.

Is NiceRx a Trudhesa coupon provider?

NiceRx is not a Trudhesa coupon, Trudhesa discount card, or Trudhesa copay card provider. We do not offer Trudhesa manufacturer coupons, Trudhesa discounts, rebates, Trudhesa savings cards, trial offers, or free Trudhesa samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Can NiceRx help me get Trudhesa cheaper if I have insurance?

NiceRx may be able to help you if:

  • You have a high copay or coinsurance responsibility for Trudhesa
  • Your insurance company will not pay for your Trudhesa prescription
  • Your healthcare plan does not cover your medication
  • You do not have insurance

Please apply online to find out if we can help you.

How much does Trudhesa cost without insurance?

Without insurance, Trudhesa costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Trudhesa nasal spray (4 mg/mL) will cost around $900 for 4 milliliters.

How much does Trudhesa cost with insurance?

The copay for Trudhesa will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is Trudhesa?

Trudhesa is an ergotamine derivative manufactured by Impel NeuroPharma, Inc., with FDA approval (U.S. Food and Drug Administration) for the acute treatment of migraine attacks with or without aura in adults. Trudhesa is not recommended for the preventive treatment of migraine or for the management of hemiplegic or basilar migraine.

What doses of Trudhesa are available?

Trudhesa is available as a nasal spray, in the following doses: 0.725 mg per spray.

Trudhesa uses advanced Precision Olfactory Delivery (POD) technology to deliver dihydroergotamine into your bloodstream through the vascular-rich upper nasal space (nostril).

If you have risk factors you are advised to take your first dose of Trudhesa in your doctor’s office or in another medical setting. Please read the full prescribing information and always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Trudhesa active ingredients

The active ingredient of Trudhesa is dihydroergotamine mesylate (DHE). It is classed as an ergot alkaloid and thought to work by narrowing the blood vessels in the brain.

Trudhesa side effects

The most common adverse reactions of Trudhesa in clinical trials include:

  • Rhinitis
  • Nausea, vomiting
  • Altered sense of taste, pharyngitis
  • Application site reactions
  • Dizziness, somnolence
  • Diarrhea

In rare instances, Trudhesa can cause more serious side effects. These can include:

  • Myocardial ischemia and/or infarction
  • Cerebrovascular adverse reactions and fatalities
  • Other vasospasm-related adverse reactions or elevation in blood pressure
  • Medication overuse headache
  • Preterm labor
  • Fibrotic complications
  • Local irritation

Your doctor will assess the benefits of using Trudhesa against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Trudhesa to the FDA. Visit, or call 1-800-FDA-1088.

Trudhesa drug interactions

Trudhesa can interact with other medications. These include:

  • Beta-Blockers
  • Nicotine
  • Selective serotonin reuptake inhibitors
  • Serious and life-threatening peripheral ischemia associated with coadministration with strong CYP3A4 inhibitors such as protease inhibitors (ritonavir, nelfinavir, indinavir) and macrolide antibiotics – erythromycin, clarithromycin
  • Azole antifungals – ketoconazole, itraconazole
  • Ergotamine or other ergot-type 5-HT1 agonists within 24 hours, such as sumatriptan

This list is not exhaustive and other prescription drugs may interact with Trudhesa.

Trudhesa contraindications

You should not use Trudhesa if you:

  • Are allergic to the active ingredient dihydroergotamine mesylate or other ergot alkaloids
  • Are allergic to any of the other ingredients in Trudhesa
  • Have ischemic heart disease or coronary artery vasospasm
  • Have uncontrolled hypertension, or peripheral arterial diseases
  • Have sepsis, following vascular surgery
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Trudhesa if you:

  • Are taking any of the medications that could interact with Trudhesa
  • Have high blood pressure
  • Have high blood cholesterol
  • Are obese
  • Have diabetes
  • Are a smoker or tobacco user
  • Have a family history of heart disease
  • Are breastfeeding or are planning to breastfeed

Trudhesa generic

Trudhesa is the trademark brand name for dihydroergotamine mesylate manufactured by Impel NeuroPharma, Inc. A generic version of dihydroergotamine mesylate is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Trudhesa savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.