Xenleta Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Xenleta cost savings if eligible

The Xenleta patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Xenleta, regardless of the retail price.

Am I eligible for the Xenleta patient assistance program?

To find out if you are eligible for Xenleta assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Xenleta patient assistance program?

Our application process aims to make it as easy as possible to apply for the Xenleta patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Xenleta.

NiceRx will review your application and determine whether you may be eligible for Xenleta assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Xenleta patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period, we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Xenleta.

Is NiceRx a Xenleta coupons provider?

NiceRx is a service provider that helps eligible individuals access the Xenleta patient assistance program. We do not offer trial offers or free Xenleta samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Xenleta coupons, discount cards, or Xenleta copay cards.

Can NiceRx help me get Xenleta if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Xenleta medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Xenleta cost without insurance?

Xenleta prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Xenleta oral tablet 600 mg typically costs $1,450 for 10 tablets.

How much does Xenleta cost with insurance?

The copay for Xenleta will vary by the terms of your healthcare plan. To find out what you might need to pay for Xenleta with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Xenleta?

Xenleta is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Nabriva Therapeutics US, Inc.

Xenleta is a systemic pleuromutilin antibacterial used for the treatment of adults with community-acquired bacterial pneumonia (CABP) caused by Streptococcus pneumoniae, Staphylococcus aureus (methicillin-susceptible isolates), Haemophilus influenzae, Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumonia.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Xenleta and other antibacterial drugs, Xenleta should be used only to treat or prevent bacterial infections that are proven or strongly suspected to be caused by bacteria, and not viral infections.

The safety and effectiveness of Xenleta in pediatric patients less than 18 years of age have not been established.

What doses of Xenleta are available?

Xenleta is available in tablet and injection form, in the following doses: 600 mg, 150 mg of lefamulin in 15 mL of 0.9% sodium chloride for further dilution prior to intravenous infusion.

Take Xenleta tablets at least 1 hour before a meal or 2 hours after a meal. Infuse Xenleta injection over 60 minutes. Reduce the dosage of Xenleta injection to 150 mg infused over 60 minutes every 24 hours in patients with severe hepatic impairment. Xenleta tablets have not been studied and are not recommended for patients with moderate or severe hepatic impairment.

See full prescribing information for additional information on the administration and preparation of Xenleta tablets and Injection. Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Xenleta active ingredients

The active ingredient in Xenleta is lefamulin.

Xenleta side effects

The most common adverse reactions of Xenleta in clinical trials include:

  • Administration site reactions
  • Hepatic enzyme elevation
  • Nausea, vomiting
  • Hypokalemia
  • Insomnia
  • Headache
  • Diarrhea

In rare instances, Xenleta can cause more serious adverse effects. These can include:

  • QT Prolongation – avoid in patients with known QT prolongation, ventricular arrhythmias including torsades de pointes, and patients receiving drugs that prolong the QT interval such as antiarrhythmic agents
  • Embryo-Fetal Toxicity
  • Clostridium difficile-associated Diarrhea (CDAD)

Your doctor will assess the benefits of using Xenleta against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Xenleta to the FDA. Visit, or call 1-800-FDA-1088.

Xenleta drug interactions

Xenleta can interact with other medications. These include:

  • Strong or moderate CYP3A inducers or P-gp inducers
  • Strong CYP3A inhibitors or P-gp inhibitors
  • Moderate CYP3A inhibitors or P-gp inhibitors
  • CYP3A4 substrates that prolong the QT interval
  • Midazolam and other sensitive CYP3A substrates

This list is not exhaustive and other prescription drugs may interact with Xenleta.

Xenleta contraindications

You should not use Xenleta if you:

  • Are allergic to the active ingredient lefamulin or pleuromutilin class drugs
  • Are allergic to any of the other ingredients in Xenleta
  • Are a pregnant woman or are planning to become pregnant – females of reproductive potential should use effective contraception during treatment and for 2 days after the last dose

Talk to your doctor before using Xenleta if you:

  • Are taking any of the medications that could interact with Xenleta
  • Are breastfeeding or are planning to breastfeed – lactating women should pump and discard human milk for the duration of treatment and for 2 days after the final dose
  • Have a renal or hepatic impairment

Xenleta generic

Xenleta is the trademark brand name for lefamulin manufactured by Nabriva Therapeutics US, Inc. A generic version of lefamulin is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Xenleta savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.