Xermelo Coupon & Prices

Is your Xermelo medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Xermelo medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

How it works

  • Enroll online

    Get started by filling out the online enrollment application to find out if you are eligible for assistance.

  • Pre-qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.

  • Submit documents

    We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.

  • Receive medication

    Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Xermelo cost savings if eligible

If you are eligible for the Xermelo patient assistance program, the cost of your medication will be free. We only charge $49 per month for each medication, to cover our service fees. You could receive your Xermelo prescription for just $49 a month, regardless of the retail price of your medication.

Am I eligible for the Xermelo patient assistance program?

We will review your application to determine whether you are eligible for the Xermelo patient assistance program. Each program has its own eligibility criteria which are set by the pharmaceutical companies, however, the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Xermelo patient assistance program?

We make it as easy as possible to apply for the Xermelo patient assistance program. The first step is to complete our enrollment application. Tell us about any medications you are taking, including Xermelo. We will also ask for details about your healthcare provider, insurance, and your household income. This information is required by the pharmaceutical manufacturers who ship your medication.

If we determine that you may be eligible for Xermelo assistance, we will handle the application process for you. We will work directly with your healthcare provider to prepare your application documents. Once we have received the signed application and supporting documents, we will submit them to the patient assistance program on your behalf. Our service continues once you are enrolled in the Xermelo patient assistance program, and we will automatically request your Xermelo medication refills for up to 1 year.

Is NiceRx a Xermelo coupons provider?

We are a service provider that helps eligible individuals access the Xermelo patient assistance program. That means that we do not offer printable Xermelo manufacturer coupons, Xermelo discounts, or free Xermelo samples. We are not a Xermelo coupon provider or Xermelo discount card. Our service extends to assisting eligible individuals to access the medications they need through patient assistance programs.

Can NiceRx help me get Xermelo if I have insurance?

We may be able to help you to access Xermelo patient assistance in a variety of circumstances. This includes when your insurance company will not pay for your Xermelo medication or if you have a high copay or coinsurance responsibility. We may also be able to help you if you do not have insurance. Please apply online to find out more.

How much does Xermelo cost without insurance?

Xermelo cost without insurance will vary depending on where you buy it. As a guide, Xermelo oral tablets 250 mg usually cost $7,900 for a supply of 84 tablets. With NiceRx you will pay a flat monthly fee of $49, regardless of the retail price of your medication.

How much does Xermelo cost with insurance?

The copay for Xermelo with insurance depends on the terms of your healthcare plan. To find out how much this is, your healthcare provider or pharmacist will be able to calculate your copay with your current insurance.

What is Xermelo?

Xermelo is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Lexicon Pharmaceuticals Inc. Xermelo is a tryptophan hydroxylase inhibitor indicated for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in adults inadequately controlled by SSA therapy.

What doses of Xermelo are available?

Xermelo is available in tablet form, in the following doses: 250 mg telotristat ethyl.

The recommended dose in adult patients is Xermelo 250 mg tablet three times daily for patients whose diarrhea is inadequately controlled by an SSA therapy. Take Xermelo with food. When short-acting octreotide is used in combination with Xermelo, give short-acting octreotide at least 30 minutes after Xermelo. Stop Xermelo if severe constipation develops. If a dose is missed, skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

Xermelo comes in a monthly case that contains 4 weekly boxes. 1 box of 7 daily doses for use each week. Keep each tablet in the package until you are ready to use. Store at room temperature away from moisture and heat.

Always speak with your healthcare professional about any medical advice or for any changes to your dose so they can monitor and evaluate your condition.

Xermelo active ingredients

Telotristat ethyl is an inhibitor of tryptophan hydroxylase, an enzyme that regulates the rate-limiting step in serotonin biosynthesis. Serotonin plays a part in regulating secretion, motility, inflammation, and sensation of the gastrointestinal tract, and is over-produced in patients with carcinoid syndrome. By inhibition of tryptophan hydroxylase, telotristat and telotristat ethyl reduce the production of serotonin, and the frequency of carcinoid syndrome diarrhea.

Xermelo side effects

The most common side effects of Xermelo in clinical trials include:

  • Nausea
  • Headache
  • Depression
  • Flatulence, or decreased appetite
  • Peripheral edema
  • Pyrexia

In rare instances, Xermelo can cause more serious adverse effects. These can include:

  • Constipation – monitor patients for constipation and/or severe persistent or worsening abdominal pain. Stop treatment if severe constipation or abdominal pain develops

Your doctor will assess the benefits of using Xermelo against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Xermelo to the FDA. Visit, or call 1-800-FDA-1088.

Xermelo drug interactions

Xermelo can interact with other medications. These include:

  • CYP3A4 Substrates (midazolam) – concomitant use of Xermelo may decrease the efficacy of CYP3A4 substrates

This list is not exhaustive and other prescription drugs may interact with Xermelo.

Xermelo contraindications

You should not use Xermelo if you:

  • Are allergic to the active ingredient telotristat ethyl
  • Are allergic to any of the other ingredients in Xermelo
  • Have a moderate or severe hepatic impairment
  • Are younger than 18 years old

Talk to your doctor before using Xermelo if you:

  • Are taking any of the medications that could interact with Xermelo
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed
  • Have or have had liver disease

Xermelo generic

Xermelo is the trademark brand name for telotristat ethyl manufactured by Lexicon Pharmaceuticals Inc. A generic version of telotristat ethyl is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Xermelo savings through NiceRx.

Related conditions

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.