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Medically reviewed by  Jamie Winn, PharmD

Your monthly Xpovio cost savings if eligible

The Xpovio patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Xpovio, regardless of the retail price.

Am I eligible for the Xpovio patient assistance program?

To find out if you are eligible for Xpovio assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Xpovio patient assistance program?

Our application process aims to make it as easy as possible to apply for the Xpovio patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Xpovio.

NiceRx will review your application and determine whether you may be eligible for Xpovio assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Xpovio patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period, we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Xpovio.

Is NiceRx an Xpovio coupons provider?

NiceRx is a service provider that helps eligible individuals access the Xpovio patient assistance program. We do not offer trial offers or free Xpovio samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Xpovio coupons, discount cards, or Xpovio copay cards.

Can NiceRx help me get Xpovio if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Xpovio medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Xpovio cost without insurance?

Xpovio prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Xpovio oral tablets 20 mg typically cost $24,100 for a supply of 8 tablets.

How much does Xpovio cost with insurance?

The copay for Xpovio will vary by the terms of your healthcare plan. To find out what you might need to pay for Xpovio with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Xpovio?

Xpovio is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Karyopharm Therapeutics Inc.

Xpovio is a nuclear export inhibitor used:

  • In combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy
  • In combination with dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is refractory to at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti‐CD38 monoclonal antibody
  • For the treatment of adult patients with relapsed or refractory diffuse large b-cell lymphoma (DLBCL), not otherwise specified, including DLBCL arising from follicular lymphoma, after at least 2 lines of systemic therapy

This is approved under accelerated approval based on the response rate. Continued approval for this may depend upon verification and description of clinical benefit in the confirmatory trial(s).

What doses of Xpovio are available?

Xpovio is available in tablet form, in the following doses: 20 mg.

For multiple myeloma in combination with bortezomib (Velcade) and dexamethasone, the recommended dose of Xpovio is 100 mg, taken orally once weekly in combination with bortezomib and dexamethasone.

For multiple myeloma in combination with dexamethasone, the recommended dosage of Xpovio is 80 mg taken orally on Days 1 and 3 of each week in combination with dexamethasone.

For DLBCL the recommended dosage of Xpovio is 60 mg taken orally on Days 1 and 3 of each week until disease progression or unacceptable toxicity.

Your doctor will carry out blood tests to monitor your complete blood count (CBC), standard blood chemistry panel, and bodyweight before you start Xpovio and as needed during treatment.

Please see the medication guide and the full prescribing information for Xpovio. Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Xpovio active ingredients

Xpovio contains the active ingredient selinexor. Selinexor reversibly inhibits nuclear export of tumor suppressor proteins (TSPs), growth regulators, and mRNAs of oncogenic proteins by blocking exportin 1 (XPO1).

The inhibition of XPO1 by selinexor leads to the build-up of TSPs in the nucleus and reductions in several oncoproteins, such as c-myc and cyclin D1, cell cycle arrest, and death of cancer cells.

Xpovio side effects

The most common side effects of Xpovio in clinical trials include:

  • Tiredness, shortness of breath
  • Nausea, vomiting, decreased appetite, diarrhea, weight loss
  • Peripheral neuropathy
  • Lymphopenia
  • Hypophosphatemia
  • Anemia
  • Constipation
  • Dyspnea
  • Upper respiratory tract infection
  • Pyrexia

In rare instances, Xpovio can cause more serious side effects. These can include:

  • Thrombocytopenia (low platelet count)
  • Neutropenia – monitor neutrophil counts throughout treatment
  • Leukopenia (low white blood cells)
  • Gastrointestinal Toxicity
  • Hyponatremia – monitor serum sodium levels
  • Serious infections
  • Neurological Toxicity – Refrain from driving and engaging in hazardous occupations or activities until neurological toxicity resolves. Optimize hydration status and concomitant medications to avoid dizziness or mental status changes
  • Cataract – treatment of cataracts usually requires surgical removal of the cataract

Your doctor will assess the benefits of using Xpovio against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Xpovio to a healthcare professional or the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Xpovio drug interactions

Currently, there is no data with regards to interactions with other medications, however tell your doctor about all the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements. Talk with your healthcare provider before taking any new medicines.

Xpovio contraindications

You should not use Xpovio if you:

  • Are allergic to the active ingredient selinexor
  • Are allergic to any of the other ingredients in Xpovio
  • Are pregnant or are planning to become pregnant – Embryo‐Fetal Toxicity. Females of reproductive potential and males with a female partner of reproductive potential should use effective contraception. Keep using birth control for at least 1 week after your last dose
  • Are younger than 18 years old

Talk to your doctor before using Xpovio if you:

  • Are taking any of the medications that could interact with Xpovio
  • Are breastfeeding or are planning to breastfeed
  • Have cataracts
  • Have bleeding problems
  • Have an active or recent infection

Xpovio generic

Xpovio is the trademark brand name for selinexor manufactured by Karyopharm Therapeutics Inc. A generic version of selinexor is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Xpovio savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.