Yondelis Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Yondelis cost savings if eligible

The Yondelis patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Yondelis, regardless of the retail price.

Am I eligible for the Yondelis patient assistance program?

To find out if you are eligible for Yondelis assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Yondelis patient assistance program?

Our application process aims to make it as easy as possible to apply for the Yondelis patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Yondelis.

NiceRx will review your application and determine whether you may be eligible for Yondelis assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Yondelis patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Yondelis.

Is NiceRx a Yondelis coupon provider?

NiceRx is a service provider that helps eligible individuals access the Yondelis patient assistance program. We do not offer trial offers or free Yondelis samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Yondelis coupons, discount cards, or Yondelis copay cards.

Can NiceRx help me get Yondelis cheaper if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Yondelis medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Yondelis cost without insurance?

Yondelis prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Yondelis intravenous powder for injection 1 mg typically costs $3,300 for 1 powder for injection.

How much does Yondelis cost with insurance?

The copay for Yondelis will vary by the terms of your healthcare plan. To find out what you might need to pay for Yondelis with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Yondelis?

Yondelis is an FDA (U.S. Food and Drug Administration) approved medication manufactured by PharmaMar and marketed by Janssen Products. Yondelis is an alkylating drug indicated for the treatment of patients with unresectable or metastatic liposarcoma or leiomyosarcoma (advanced soft tissue sarcoma) who received a prior anthracycline-containing regimen.

In clinical trials, Yondelis significantly increased progression-free survival compared to dacarbazine. This is an important endpoint for these patients, in whom rapid worsening of the disease can lead to worse symptoms and life-threatening situations.

Yondelis is also used in combination with pegylated liposomal doxorubicin (PLD) is indicated for the treatment of patients with relapsed platinum-sensitive ovarian cancer.

What doses of Yondelis are available?

Yondelis is available in injection form, in the following doses: 1 mg sterile lyophilized powder in a single-dose vial.

The recommended dose of Yondelis is 1.5 mg/m2 body surface area as a 24-hour intravenous infusion, every 3 weeks through a central venous line. Give dexamethasone 20 mg intravenously, 30 min before each infusion. For patients with hepatic Impairment administer at 0.9 mg/m2 body surface area as a 24-hour intravenous infusion, every 3 weeks through a central venous line.

Always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Yondelis active ingredients

Yondelis contains trabectedin as the active ingredient.

Yondelis side effects

The most common side effects of trabectedin in clinical trials include:

  • Nausea, fatigue, vomiting, constipation, decreased appetite, diarrhea, peripheral edema, dyspnea, and headache
  • Laboratory abnormalities – febrile neutropenia, increased ALT, thrombocytopenia (low platelet levels), anemia (low red blood cell count), increased AST, increased creatine phosphokinase, elevations in liver enzymes

In rare instances, Yondelis can cause more serious side effects. These can include:

  • Neutropenic sepsis – monitor neutrophil count during treatment
  • Rhabdomyolysis – monitor creatine phosphokinase (CPK) levels prior to each administration. Withhold treatment for CPK more than 2.5 times the upper limit of normal
  • Hepatotoxicity – yellowing of skin and eyes, pain in the upper right abdomen, severe nausea or vomiting, difficulty in concentrating, disorientation, or confusion
  • Cardiomyopathy
  • Capillary leak syndrome
  • Embryo-fetal toxicity

Your doctor will assess the benefits of using Yondelis against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Yondelis to the FDA. Visit, or call 1-800-FDA-1088.

Yondelis drug interactions

Yondelis can interact with other medications. These include:

  • Strong CYP3A inhibitors
  • Strong CYP3A inducers – rifampin, phenobarbital, St. John’s wort
  • Avoid the use of grapefruit products

This list is not exhaustive and other prescription drugs may interact with Yondelis.

Yondelis contraindications

You should not use Yondelis if you:

  • Are allergic to the active ingredient trabectedin
  • Are allergic to any of the other ingredients in Yondelis
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Yondelis if you:

  • Are taking any of the medications that could interact with Yondelis
  • Have hepatic Impairment – you may need a blood test to check your liver function
  • Are breastfeeding or are planning to breastfeed

Yondelis generic

Yondelis is the trademark brand name for trabectedin manufactured by PharmaMar. A generic version of trabectedin is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Yondelis savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.