Is NiceRx a Zavesca coupon provider?
NiceRx is not a Zavesca coupon, Zavesca discount card, or Zavesca copay card provider. We do not offer Zavesca manufacturer coupons, Zavesca discounts, rebates, Zavesca savings cards, trial offers, or free Zavesca samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.
Zavesca patient assistance program
Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.
How much does Zavesca cost without insurance?
Without insurance, Zavesca costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Zavesca oral capsules 100 mg will cost around $28,250 for 90 capsules.
How much does Zavesca cost with insurance?
The copay for Zavesca will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.
What is Zavesca?
Zavesca is an FDA (U.S. Food and Drug Administration) approved medication manufactured for Actelion Pharmaceuticals US, Inc., a Janssen Pharmaceutical Company. It is a glucosylceramide synthase inhibitor (the enzyme responsible for the first step in the synthesis of most glycosphingolipids) indicated as monotherapy to treat adult patients with mild to moderate type 1 Gaucher disease for whom enzyme replacement therapy (ERT) is not an option.
Type 1 Gaucher disease is caused by a lack of glucocerebrosidase, the enzyme needed for the breakdown of glycosphingolipid glucosylceramide. Lipids build up in the body and cause symptoms such as easy bruising or bleeding, weakness, anemia, bone or joint pain, enlarged liver or spleen, or weakened bones.
Zavesca is also used in patients of all ages with Niemann-Pick type-C disease, a potentially fatal disease in which glycosphingolipids build up within cells in the brain and elsewhere in the body. Zavesca is used to treat neurological symptoms which include loss of coordination, problems with eye movements that can lead to vision problems, delayed development, problems swallowing, decreased muscle tone, seizures, and learning difficulties.
What doses of Zavesca are available?
Zavesca is available in capsule form, in the following doses: 100 mg.
The recommended dosage is a 100 mg capsule, three times a day at regular intervals. The dose may be reduced to 100 mg once or twice a day in patients due to tremors or diarrhea. Dosing for patients under the age of 12 years should be adjusted according to body surface area.
Please read the patient information provided with your medication and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.
Zavesca active ingredients
The active ingredient of Zavesca is miglustat.
Zavesca side effects
The most common side effects of Zavesca in clinical trials (incidence ≥5%) include:
- Constipation, weight loss, stomach pain, flatulence, nausea, and vomiting
- Diarrhea can be serious – you may need to make changes to your diet, such as avoiding foods high in carbohydrates
- Headache, including migraine
- Tremor, leg cramps, dizziness, weakness
- Vision problems
- Thrombocytopenia (reduced platelet count)
- Muscle cramps, back pain
- Dry mouth
- Memory loss, unsteady walking
- Stomach bloating, abdominal pain not related to food, and menstrual changes
In rare instances, Zavesca can cause more serious side effects. These can include:
- Peripheral neuropathy – perform baseline and follow-up neurological evaluations at 6-month intervals
- Tremor or exacerbation of existing tremors
Your doctor will assess the benefits of using Zavesca against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Zavesca to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Zavesca drug interactions
Other drugs may interact with Zavesca, including prescription drugs and over-the-counter medicines, vitamins, and herbal products. Tell your health care provider about all of your medication including any supplements you are taking.
You should not use Zavesca if you:
- Are allergic to the active ingredient miglustat
- Have known hypersensitivity to any of the other ingredients in Zavesca
- Are pregnant or are planning to become pregnant – Based on animal data, may cause fetal harm
- Are breastfeeding or are planning to breastfeed – changes in lactation were seen in animal studies and it is likely to be present in breast milk
Talk to your doctor about your medical conditions before using Zavesca if you:
- Are taking any of the medications that could interact with Zavesca such as imiglucerase
- Have stomach problems
- Have gastrointestinal disease, such as inflammatory bowel disease
- Have kidney disease
- Have a condition that causes tremors
Zavesca is the trademark brand name for miglustat manufactured for Actelion Pharmaceuticals US, Inc., a Janssen Pharmaceutical Company. A generic version of miglustat is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Zavesca savings through NiceRx.
The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.