Zulresso Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Zulresso cost savings if eligible

If you are eligible for the Zulresso patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Zulresso through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Zulresso patient assistance program?

You could receive your Zulresso without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies that are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Zulresso patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Zulresso.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Zulresso patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Zulresso medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx a Zulresso coupons provider?

At NiceRx, we help eligible individuals access the Zulresso patient assistance program. This means that we are not a Zulresso coupon, a Zulresso discount card, or a Zulresso copay card provider. We do not offer any medication trial offers or free Zulresso samples.

Can NiceRx help me get Zulresso if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Zulresso medication, or you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Zulresso cost without insurance?

Zulresso costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Zulresso intravenous solution (5 mg/mL) will typically cost around $7,800 for a supply of 20 milliliters. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

How much does Zulresso cost with insurance?

The copay of Zulresso will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Zulresso?

Zulresso is a controlled substance with FDA (U.S. Food and Drug Administration) approval. It is manufactured by Sage Therapeutics, Inc.

Zulresso is classed as a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor positive modulator, used for the treatment of postpartum depression (PPD) in adults.

Postpartum depression is a distinct and identifiable major depressive disorder. It occurs in 20% of postpartum moms. Without treatment, depressed Moms are more likely to have an impairment of bonding with their babies. Untreated depression and anxiety during and after pregnancy can cause issues with children, such as cognitive and developmental delays, a lack of self-control, aggression, and an increased risk of substance abuse.

Depression and Anxiety are the most common mental health disorders in pregnancy and postpartum. Clinical trials show that Zulresso can help women reduce depressive symptoms.

What doses of Zulresso are available?

Zulresso is available in injection form, in the following doses: 100 mg/20 mL (5 mg/mL) single-dose vial.

A healthcare provider must be available on-site to monitor the patient at a certified healthcare facility and intervene if required during the infusion. Zulresso infusion is given as a continuous intravenous infusion over 60 hours (2.5 days). The diluted product can only be used for 12 hours at room temperature, so each 60-hour infusion will need at least five infusion bags to be prepared.

For more serious symptoms, an antidepressant, such as Prozac, is often added to support lifestyle regimen, to help stabilize brain chemistry. Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition. Keep all follow-up visits with your healthcare provider as scheduled.

Zulresso active ingredients

The exact mechanism of action of brexanolone to treat postpartum depression in adults is not fully understood but is thought to relate to its positive allosteric modulation of GABA receptors.

Zulresso side effects

The most common side effects of Zulresso in clinical studies include:

  • Somnolence
  • Sleepiness
  • Dry mouth
  • Loss of consciousness
  • Flushing

In rare instances, Zulresso can cause more serious side effects. These can include:

  • Suicidal thoughts and behaviors, or thoughts of self-harm
  • Excessive drowsiness
  • Sudden changes in mood or behavior
  • Worsening depression

Your doctor will assess the benefits of using Zulresso against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Zulresso to the FDA. Visit, or call 1-800-FDA-1088.

Zulresso drug interactions

Zulresso can interact with other medications. These include:

  • Benzodiazepines used to treat anxiety can increase the risk of serious side effects
  • Opioids
  • Other central nervous systems (CNS) depressants

This list is not exhaustive and other prescription drugs may interact with Zulresso. Tell your healthcare provider about all the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements.

Zulresso contraindications

You should not use Zulresso if you:

  • Are allergic to the active ingredient brexanolone
  • Are pregnant or planning to become pregnant
  • Are younger than 18 years old

Talk to your doctor before using Zulresso if you:

  • Are taking any of the medications that could interact with Zulresso
  • Are breastfeeding or plan to breastfeed – Zulresso passes into breast milk
  • Have end-stage renal disease (ESRD)
  • Drink large amounts of alcohol


See full prescribing information for a complete boxed warning

  • Patients are at risk of excessive sedation or sudden loss of consciousness – because of the risk of serious harm, patients must be monitored for excessive sedation and sudden loss of consciousness and have continuous pulse oximetry monitoring
  • Patients must be accompanied during interactions with their child(ren)
  • Zulresso is only available through a restricted program called the Zulresso REMS. (risk evaluation and mitigation strategy)

Zulresso generic

Zulresso is the trademark brand name for brexanolone manufactured by Sage Therapeutics, Inc. A generic version of brexanolone is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Zulresso savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.