Zyclara Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Zyclara cost savings if eligible

If you are eligible to receive your Zyclara prescription through the patient assistance program, your medication will be free. We charge a flat monthly service fee of $49 per medication to cover the cost of our services.

Am I eligible for Zyclara patient assistance?

To be eligible for the Zyclara patient assistance program, you will need to meet specific eligibility criteria set by the pharmaceutical company. At NiceRx, we review each Zyclara enrollment application individually. The main factors considered are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Zyclara patient assistance program?

Applying for the Zyclara patient assistance program through NiceRx is simple. Begin by completing the enrollment application on our website. We will ask for details about your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers that supply your medication. We may be able to help you access patient assistance for other medications as well as Zyclara, so please tell us about any medications that you have been prescribed.

If we determine that you may be eligible for Zyclara assistance, we will handle the full enrollment process on your behalf. We will work with your healthcare provider to prepare and submit all the documents required for you to enroll. If you are successfully enrolled in the Zyclara patient assistance program, we will also request your Zyclara medication refills on your behalf for up to 1 year. At the end of your enrollment period, we will contact you for updated details and seek to re-enroll you in the program.

Is NiceRx a Zyclara coupons provider?

NiceRx does not provide Zyclara coupons, discount cards, or copay cards. We do not offer printable Zyclara manufacturer coupons, Zyclara discounts, rebates, Zyclara savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Zyclara medication with NiceRx.

Can NiceRx help me get Zyclara if I have insurance?

NiceRx may be able to help you access Zyclara patient assistance if:

  • You have a high copay or coinsurance responsibility for Zyclara
  • Your insurance company will not pay for your Zyclara prescription
  • You do not have insurance

Complete your enrollment application online to find out more.

How much does Zyclara cost without insurance?

Zyclara prices without insurance will vary by retailer. As a guide, Zyclara topical cream 3.75% will typically cost around $1.300 for 7.5 grams.

How much does Zyclara cost with insurance?

Your individual healthcare plan will determine the copay of Zyclara with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Zyclara?

Zyclara is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Meda Pharmaceuticals. Zyclara (imiquimod) topical treatment, 2.5% or 3.75% is an immune response modifier used to treat actinic keratoses (AK) of the face or balding scalp. (AK are precancerous skin conditions caused by too much sun exposure).

Treatment with Zyclara Cream has not been studied for the prevention of transmission of human papillomavirus (HPV). Zyclara is not a cure for genital warts. You may still spread this condition to others through vaginal, anal, or oral sex. You also may develop new lesions during treatment.

What doses of Zyclara are available?

Zyclara is available in cream form, in the following doses: 3.75%, white to faintly yellow cream.

Treatment with Zyclara is easier to adhere to than Aldara treatment because it has a simpler dosing regimen. Using too much Zyclara or using it for too long can increase your risk of severe skin reactions. Do not use two different forms of imiquimod on the same treatment area. If you miss a dose, use it as soon as you remember. If you do not remember until the next day, skip the missed dose. Use your next dose at the regular time in the evening. Do not double the dose.

The recommended dose is once daily to the skin of the affected area (either the entire face or balding scalp) for two 2-week treatment cycles separated by a 2-week rest period. Apply the cream in a thin layer and rub it completely. Use at bedtime and leave the medicine on for 8 hours. Wash the skin in the morning with water and mild soap. Do not cover the treated area with any type of plastic bandaging (you may use cotton gauze). Wear only cotton underwear when treating genital warts.

Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Do not apply this medication to sunburned skin. How often and how long you use Zyclara will depend on the condition you are treating.

Actinic keratosis:

  • Apply once daily for 2 weeks, followed by 2 weeks without treatment

External genital warts:

  • Apply once daily for up to 8 weeks

Store the cream at room temperature. Store the pump version in an upright position and keep each packet unopened until you are ready to use it. Please read the patient information for more drug information and always speak with a healthcare professional for medical advice or about any changes to your dose so they can monitor and evaluate your condition.

Zyclara active ingredients

The active ingredient in Zyclara is imiquimod.

Zyclara side effects

The most common side effects of Zyclara in clinical trials include:

  • Local skin reactions – erythema, skin irritation, edema, weeping exudate, flaking, scaling, dryness, scabbing, crusting, erosion, ulceration
  • Changes in the color of treated skin

In rare instances, Zyclara can cause more serious adverse effects. These can include:

  • Intense local inflammatory reactions can occur
  • Flu-like symptoms – tiredness, chest pain, nausea, fever, myalgias, arthralgias, chills, headache, back pain
  • Bleeding or swelling where you applied the cream
  • Symptoms of herpes zoster (shingles)

Your doctor will assess the benefits of using Zyclara against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Zyclara to the FDA. Visit, or call 1-800-FDA-1088.

Zyclara drug interactions

There is currently no data for Zyclara interactions with other medications. Tell your healthcare provider about all the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements.

Zyclara contraindications

You should not use Zyclara if you:

  • Are allergic to the active ingredient imiquimod
  • Have had an allergic reaction to any of the other ingredients in Zyclara
  • Are using any other imiquimod cream

Talk to your doctor before using Zyclara if you:

  • Are taking any of the medications that could interact with Zyclara
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed – it is unknown if this drug passes into breast milk
  • Are immunosuppressed, have a weak immune system or autoimmune disorder
  • Have sunburn or other skin problems
  • Have a graft-versus-host disease
  • Are a child under 12 years of age

If you are treating the genital or rectal area, avoid sexual contact while the medicine is on your skin. Zyclara cream can weaken rubber condoms or diaphragms, which could break during sex.

Zyclara generic

Zyclara is the trademark brand name for imiquimod manufactured by Meda Pharmaceuticals. A generic version of imiquimod is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Zyclara savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.