Zynrelef Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Zynrelef cost savings if eligible

If you are eligible for the Zynrelef patient assistance program, the cost of your medication will be free. We only charge $49 per month for each medication, to cover our service fees. You could receive your Zynrelef prescription for just $49 a month, regardless of the retail price of your medication.

Am I eligible for the Zynrelef patient assistance program?

We will review your application to determine whether you are eligible for the Zynrelef patient assistance program. Each program has its own eligibility criteria which is set by the pharmaceutical companies, however, the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Zynrelef patient assistance program?

We make it as easy as possible to apply for the Zynrelef patient assistance program. The first step is to complete our enrollment application. Tell us about any medications you are taking, including Zynrelef. We will also ask for details about your healthcare provider, insurance, and your household income. This information is required by the pharmaceutical manufacturers who ship your medication.

If we determine that you may be eligible for Zynrelef assistance, we will handle the application process for you. We will work directly with your healthcare provider to prepare your application documents. Once we have received the signed application and supporting documents, we will submit them to the patient assistance program on your behalf. Our service continues once you are enrolled in the Zynrelef patient assistance program, and we will automatically request your Zynrelef medication refills for up to 1 year.

Is NiceRx a Zynrelef coupon provider?

We are a service provider that helps eligible individuals access the Zynrelef patient assistance program. That means that we do not offer printable Zynrelef manufacturer coupons, Zynrelef discounts, or free Zynrelef samples. We are not a Zynrelef coupon provider or Zynrelef discount card. Our service extends to assisting eligible individuals to access the medications they need through patient assistance programs.

Can NiceRx help me get Zynrelef cheaper if I have insurance?

We may be able to help you to access Zynrelef patient assistance in a variety of circumstances. This includes when your insurance company will not pay for your Zynrelef medication or if you have a high copay or coinsurance responsibility. We may also be able to help you if you do not have insurance. Please apply online to find out more.

How much does Zynrelef cost without insurance?

Zynrelef cost without insurance will vary depending on where you buy it. As a guide, Zynrelef injectable solution, extended-release (200 mg-6 mg/7 mL) usually costs $150 for 7 milliliters. With NiceRx you will pay a flat monthly fee of $49, regardless of the retail price of your medication.

How much does Zynrelef cost with insurance?

The copay for Zynrelef with insurance depends on the terms of your healthcare plan. To find out how much this is, your healthcare provider or pharmacist will be able to calculate your copay with your current insurance.

What is Zynrelef?

Zynrelef is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Heron Therapeutics, Inc. Zynrelef has a novel mechanism of action. It is given as a single, needle-free application to the surgical site, providing patients with up to 72 hours of postoperative pain relief, and has been proven to reduce, the need for opioids after surgery. It is used in adults for soft tissue or periarticular instillation to produce postsurgical analgesia after bunionectomy, open inguinal herniorrhaphy, and total knee arthroplasty.

Zynrelef is the first and only extended-release dual-acting local anesthetic (DALA) with FDA approval. It combines bupivacaine with a low dose of meloxicam, a nonsteroidal anti-inflammatory drug (NSAID), for a synergistic analgesic effect. Safety and efficacy have not been established in highly vascular surgeries, such as intrathoracic, large multilevel spinal, and head and neck procedures.

Nonsteroidal anti-inflammatory drugs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with the duration of use. NSAIDs also cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.

What doses of Zynrelef are available?

Zynrelef is available as an extended-release solution, in the following dosage strengths as single-dose glass vials: 400 mg bupivacaine and 12 mg meloxicam, 300 mg bupivacaine and 9 mg meloxicam, 200 mg bupivacaine and 6 mg meloxicam, 60 mg bupivacaine and 1.8 mg meloxicam.

Please see the full prescribing information for the complete boxed warning and always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Zynrelef active ingredients

Zynrelef contains bupivacaine and meloxicam as the active ingredients.

Zynrelef side effects

The most common adverse reactions of Zynrelef (incidence ≥10%) in clinical trials compared to placebo include:

  • Constipation, vomiting, and headache

In rare instances, Zynrelef can cause more serious side effects. These can include:

  • Dose-related toxicity
  • Hepatotoxicity
  • Hypertension (high blood pressure)
  • Heart failure and edema
  • Renal toxicity
  • Anaphylactic reactions
  • Methemoglobinemia
  • Serious skin reactions
  • Drug reaction with eosinophilia and systemic symptoms (DRESS)
  • Fetal toxicity
  • Infertility – consider avoidance of treatment in women who have difficulties conceiving
  • Hematologic toxicity – monitor hemoglobin or hematocrit in patients with any signs or symptoms of anemia

Your doctor will assess the benefits of using Zynrelef against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Zynrelef to the FDA. Visit, or call 1-800-FDA-1088.

Zynrelef drug interactions

Zynrelef can interact with other medications. These include:

  • Drugs that interfere with hemostasis – warfarin, aspirin, SSRIs/SNRIs
  • ACE inhibitors, Angiotensin receptor blockers (ARBs), or Beta-blockers
  • Diuretics

This list is not exhaustive and other prescription drugs may interact with Zynrelef.

Zynrelef contraindications

You should not use Zynrelef if you:

  • Are allergic to the active ingredients bupivacaine or meloxicam
  • Have a known hypersensitivity to any local anesthetic agent of the amide-type, NSAIDs, or to any of the other components
  • Have a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
  • Are undergoing obstetrical paracervical block anesthesia
  • Are undergoing coronary artery bypass graft (CABG) surgery
  • Have severe hepatic impairment – only use if benefits are expected to outweigh risks. Monitor for signs of worsening liver function
  • Have severe renal impairment, avoid use of Zynrelef unless the benefits are expected to outweigh the risk of worsening renal function
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Zynrelef if you:

  • Are taking any of the medications that could interact with Zynrelef
  • Have severe heart failure
  • Are breastfeeding or are planning to breastfeed

Zynrelef generic

Zynrelef is the trademark brand name for bupivacaine and meloxicam manufactured by Heron Therapeutics, Inc. A generic version of bupivacaine and meloxicam is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Zynrelef savings through NiceRx.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.