Ajovy side effects and how to avoid them

Ajovy is a brand-name medication manufactured by Teva Pharmaceuticals. It is classed as a monoclonal antibody and is used for migraine prevention. While Ajovy is generally well tolerated, there are some potential side effects that people should be aware of. The most common side effects of Ajovy include injection site reactions. Less common, but more serious side effects, can include allergic reactions.

Learn more about the side effects of Ajovy and what you can do to avoid them.

What is Ajovy (fremanezumab-vfrm)?

Ajovy (fremanezumab) is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Teva Pharmaceuticals USA, Inc. It is a calcitonin gene-related peptide (CGRP) antagonist used for the preventive treatment of migraine (episodic migraine or chronic migraine) in adults. Ajovy can help to lower the number of migraine headache days you have each month by 1.5 to 2 days per month. Ajovy works by binding to the calcitonin gene-related peptide (CGRP) ligand preventing it from binding to its receptor.

Ajovy dosage

Ajovy is available in injection form, in the following doses: Ajovy 225 mg/1.5 mL solution in a single-dose autoinjector prefilled syringe.

Ajovy is for subcutaneous injection use only. Two dosing options are available, 225 mg monthly, or 675 mg every 3 months. You should inject each dose of Ajovy into a new area of the skin. Ajovy injections can be given into your abdomen, thighs, or upper arms. When using Ajovy take it out of the refrigerator and let it reach room temperature for 30 minutes before injecting.

Read the full prescribing information provided with this medicine for the drug information and patient information, and always speak with your healthcare provider for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Ajovy side effects

The most common side effects of Ajovy in clinical trials compared to placebo include:

  • Injection site reactions such as injection site pain, induration, pruritus, and erythema

In rare instances, Ajovy can cause more serious side effects. These can include:

  • Hypersensitivity reactions

Get emergency medical help if you have signs of a serious allergic reaction, such as hives, trouble breathing, or swelling of your face, lips, tongue, or throat.

Your doctor will assess the benefits of using Ajovy against your risk of adverse effects. Patients are encouraged to report negative side effects or adverse reactions of Ajovy to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Ajovy drug interactions

Other drugs may interact with Ajovy, including prescription drugs and over-the-counter medicines, vitamins, and herbal products. Tell your healthcare provider about all of your medication including any supplements you are taking.

Ajovy warnings & contraindications

You should not use Ajovy if you:

  • Are allergic to the active ingredient fremanezumab-vfrm
  • Have had an allergic reaction to any of the other ingredients in Ajovy
  • Are younger than 18 years old

Talk to your doctor before using Ajovy if you:

  • Are taking any of the medications that could interact with Ajovy
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed – It is unknown if this medication passes into breast milk

You should always check with your doctor or pharmacist before taking any medication, including Ajovy, to make sure it is safe for you.

How to avoid Ajovy side effects

The best way to avoid side effects is to take Ajovy as directed by your doctor. Follow your doctor’s instructions carefully and do not take more or less than prescribed.

If you experience any side effects, talk to your doctor or pharmacist. They may be able to recommend ways to help reduce or prevent some of the side effects.

1. Stick to the recommended dosage

Take your prescribed dose of Ajovy that has been recommended by your healthcare professional. Do not take more or less than prescribed.

2. Monitor your blood sugar levels

If you have diabetes, it is important to monitor your blood sugar levels closely while taking Ajovy. Check your blood sugar levels as directed by your doctor and report any changes to your doctor immediately.

3. Drink plenty of fluids

Dehydration is not a side effect of Ajovy. However, dehydration will make your symptoms of migraine worse so make sure you drink plenty of water to prevent this complication.

4. Avoid alcohol

Ajovy is not known to interact with alcohol. However, drinking alcohol can trigger a migraine attack in some people. Avoid alcohol while using Ajovy if it is a trigger for you.

5. Don’t skip meals

Eating regular meals and snacks will help to prevent low blood sugar levels (hypoglycemia).

6. Check your feet

If you have diabetes, check your feet for any cuts, sores, or redness regularly. Tell your doctor if you experience any problems with your feet while taking Ajovy.

7. Know the signs and symptoms of Ajovy side effects

Signs and symptoms of side effects include injection site reactions. If you experience any of these symptoms speak to your doctor for medical advice.

8. Monitor your weight

Weight loss or weight gain has been reported by some people using Ajovy. If you experience this side effect while taking Ajovy, get medical advice from your doctor.

9. Tell your doctor about all medications you’re taking

Be sure to tell your doctor about all other medications you’re taking, including over-the-counter drugs, vitamins, and herbal supplements, as they can interact with Ajovy.

10. Get regular medical check ups

It is important to get regular medical check ups and monitor your medical conditions. Your caregiver will monitor your side effects and may adjust your dose of Ajovy as needed.

Medically reviewed

A medical professional has reviewed this article.

Jamie Winn, PharmD
Jamie Winn, PharmD

Jamie Winn, PharmD

Medical Writer & Reviewer

Jamie Winn, PharmD

Medical Writer & Reviewer

Dr. Jamie Winn received his Doctor of Pharmacy in 2002 from the University of South Carolina College of Pharmacy, Columbia, SC. Jamie is a medical reviewer for NiceRx.

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Sources (2)

  1. Drugs.com - Ajovy

  2. FDA - highlights of prescribing information for Ajovy

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.