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Advagraf XL Patient assistance program

Is your Advagraf XL medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Advagraf XL medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: Your medication is delivered straight to your door
  • NiceRx Benefit
    Ongoing refills: Your medication is refilled automatically
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

An introduction to NiceRx

Play video (01:52)
  • An introduction to NiceRx
    (01:52)
  • Next steps after qualifying
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  • Uploading documents and billing
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  • SSN & billing information
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  • Medication delivery time
    (00:41)

How it works

  • Apply Online

    Get started by filling out the online enrollment application to find out if you are eligible.

  • Qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are qualified. The pharmaceutical company provides your medication for free and you only pay our service fee.

  • Upload Documents

    You may be required to submit further information and documents required by the pharmaceutical company which can be securely uploaded online.

  • Application Created

    Your application is created and sent to your doctor for signature. At this stage, you will be billed $49 and will not be billed again until you receive your first medication delivery.

  • Receive Medication

    Your application is sent to the pharmaceutical company. You will be billed again once you receive your medication. We handle the entire ordering process including requesting ongoing refills.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Advagraf XL cost savings if eligible

If you are eligible for the Advagraf XL patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Advagraf XL through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Advagraf XL patient assistance program?

You could receive your Advagraf XL without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies that are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Advagraf XL patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Advagraf XL.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Advagraf XL patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Advagraf XL medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx an Advagraf XL coupon provider?

At NiceRx, we help eligible individuals access the Advagraf XL patient assistance program. This means that we are not an Advagraf XL coupon, an Advagraf XL discount card, or an Advagraf XL copay card provider. We do not offer any medication trial offers, or free Advagraf XL samples.

Can NiceRx help me get Advagraf XL cheaper if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Advagraf XL medication, or if you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Advagraf XL cost without insurance?

Advagraf XL costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Advagraf capsules will typically cost around $1,300 for 100 capsules. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

How much does Advagraf XL cost with insurance?

The copay of Advagraf XL will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Advagraf XL?

Advagraf XL (tacrolimus extended-release capsules) is a medication manufactured by Astellas Pharma Australia. It is a calcineurin-inhibitor immunosuppressant used for the prophylaxis of organ rejection in kidney transplant patients with mycophenolate mofetil (MMF) and corticosteroids, with or without basiliximab induction.

What doses of Advagraf XL are available?

Advagraf XL is available as a capsule formulation, in the following doses: 0.5 mg, 1 mg, and 5 mg.

Please read the prescribing information and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Advagraf XL active ingredients

Advagraf XL contains the active substance tacrolimus. It is classed as an immunosuppressant. Your body’s immune system will try to reject the new organ after your organ transplant. Advagraf XL will control your body’s response, allowing you to accept the transplanted organ.

Other ingredients of Advagraf XL prolonged-release capsules include hypromellose, ethylcellulose, lactose, and magnesium stearate. The capsule shell contains titanium dioxide, yellow iron oxide, red iron oxide, sodium laurilsulfate, and gelatin.

Advagraf XL side effects

The most common side effects of Advagraf XL in clinical trials include:

  • Diarrhea, constipation
  • Nausea
  • Peripheral edema
  • Tremor
  • Anemia
  • Kidney problems
  • Raised blood sugar levels
  • Diabetes
  • Hyperkalaemia (raised blood potassium levels)
  • Hypertension (high blood pressure)
  • Insomnia (difficulty sleeping)

In rare instances, Advagraf XL can cause more serious side effects. These can include:

  • Increased risk for developing serious infections and malignancies that may lead to hospitalization or death
  • Increased mortality in female liver transplant patients
  • Nephrotoxicity (acute and/or chronic) – monitor renal function
  • Neurotoxicity
  • QT prolongation
  • Pure red cell aplasia
  • Heart failures, abnormal heart rhythms, chest pain
  • Venoocclusive liver disease, hepatic artery thrombosis

Your doctor will assess the benefits of using Advagraf XL against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Advagraf XL to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Advagraf XL drug interactions

Advagraf XL can interact with other medications. These include:

  • Other immunosuppressive therapy – cyclosporin
  • Macrolide antibiotics – telithromycin, erythromycin, clarithromycin
  • Azole antifungals – ketoconazole, fluconazole, itraconazole
  • HIV protease inhibitors – ritonavir, nelfinavir, saquinavir
  • Treatments for stomach ulcers and acid reflux – omeprazole, lansoprazole, or cimetidine
  • Treatments for high blood pressure or heart problems – nifedipine, nicardipine, diltiazem, and verapamil
  • Anticonvulsants – carbamazepine, phenytoin
  • NSAIDs such as ibuprofen
  • Corticosteroids – prednisolone and methylprednisolone
  • St. John’s wort
  • Grapefruit juice

This list is not exhaustive and other prescription drugs may interact with Advagraf XL. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

Advagraf XL contraindications

You should not use Advagraf XL if you:

  • Are allergic to the active ingredient tacrolimus
  • Are allergic to sirolimus or to any macrolide-antibiotics such as erythromycin, clarithromycin, or josamycin
  • Are allergic to any of the other ingredients in Advagraf XL
  • Are pregnant or are planning to become pregnant

Talk to your doctor about your medical condition before using Advagraf XL if you:

  • Are taking any of the medications that could interact with Advagraf XL
  • Are receiving treatment for hepatitis C
  • Need to have any vaccinations
  • Are breastfeeding or are planning to breastfeed – this medication passes into breast milk

Advagraf XL generic

Advagraf XL is the trademark brand name for tacrolimus manufactured by Astellas Pharma Australia. A generic version of tacrolimus is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Advagraf XL savings through NiceRx.

Related medications

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.