medicationsAdvagraf Xl

Advagraf XL Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx an Advagraf XL coupon provider?

At NiceRx, we help eligible individuals access patient assistance programs. This means that we are not an Advagraf XL coupon, an Advagraf XL discount card, or an Advagraf XL copay card provider. We do not offer any medication trial offers, or free Advagraf XL samples.

Advagraf XL patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

Can NiceRx help me get Advagraf XL cheaper if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Advagraf XL medication, or if you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Advagraf XL cost without insurance?

Advagraf XL costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Advagraf capsules will typically cost around $1,300 for 100 capsules.

How much does Advagraf XL cost with insurance?

The copay of Advagraf XL will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Advagraf XL?

Advagraf XL (tacrolimus extended-release capsules) is a medication manufactured by Astellas Pharma Australia. It is a calcineurin-inhibitor immunosuppressant used for the prophylaxis of organ rejection in kidney transplant patients with mycophenolate mofetil (MMF) and corticosteroids, with or without basiliximab induction.

What doses of Advagraf XL are available?

Advagraf XL is available as a capsule formulation, in the following doses: 0.5 mg, 1 mg, and 5 mg.

Please read the prescribing information and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Advagraf XL active ingredients

Advagraf XL contains the active substance tacrolimus. It is classed as an immunosuppressant. Your body’s immune system will try to reject the new organ after your organ transplant. Advagraf XL will control your body’s response, allowing you to accept the transplanted organ.

Other ingredients of Advagraf XL prolonged-release capsules include hypromellose, ethylcellulose, lactose, and magnesium stearate. The capsule shell contains titanium dioxide, yellow iron oxide, red iron oxide, sodium laurilsulfate, and gelatin.

Advagraf XL side effects

The most common side effects of Advagraf XL in clinical trials include:

  • Diarrhea, constipation
  • Nausea
  • Peripheral edema
  • Tremor
  • Anemia
  • Kidney problems
  • Raised blood sugar levels
  • Diabetes
  • Hyperkalaemia (raised blood potassium levels)
  • Hypertension (high blood pressure)
  • Insomnia (difficulty sleeping)

In rare instances, Advagraf XL can cause more serious side effects. These can include:

  • Increased risk for developing serious infections and malignancies that may lead to hospitalization or death
  • Increased mortality in female liver transplant patients
  • Nephrotoxicity (acute and/or chronic) – monitor renal function
  • Neurotoxicity
  • QT prolongation
  • Pure red cell aplasia
  • Heart failures, abnormal heart rhythms, chest pain
  • Venoocclusive liver disease, hepatic artery thrombosis

Your doctor will assess the benefits of using Advagraf XL against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Advagraf XL to the FDA. Visit, or call 1-800-FDA-1088.

Advagraf XL drug interactions

Advagraf XL can interact with other medications. These include:

  • Other immunosuppressive therapy – cyclosporin
  • Macrolide antibiotics – telithromycin, erythromycin, clarithromycin
  • Azole antifungals – ketoconazole, fluconazole, itraconazole
  • HIV protease inhibitors – ritonavir, nelfinavir, saquinavir
  • Treatments for stomach ulcers and acid reflux – omeprazole, lansoprazole, or cimetidine
  • Treatments for high blood pressure or heart problems – nifedipine, nicardipine, diltiazem, and verapamil
  • Anticonvulsants – carbamazepine, phenytoin
  • NSAIDs such as ibuprofen
  • Corticosteroids – prednisolone and methylprednisolone
  • St. John’s wort
  • Grapefruit juice

This list is not exhaustive and other prescription drugs may interact with Advagraf XL. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

Advagraf XL contraindications

You should not use Advagraf XL if you:

  • Are allergic to the active ingredient tacrolimus
  • Are allergic to sirolimus or to any macrolide-antibiotics such as erythromycin, clarithromycin, or josamycin
  • Are allergic to any of the other ingredients in Advagraf XL
  • Are pregnant or are planning to become pregnant

Talk to your doctor about your medical condition before using Advagraf XL if you:

  • Are taking any of the medications that could interact with Advagraf XL
  • Are receiving treatment for hepatitis C
  • Need to have any vaccinations
  • Are breastfeeding or are planning to breastfeed – this medication passes into breast milk

Advagraf XL generic

Advagraf XL is the trademark brand name for tacrolimus manufactured by Astellas Pharma Australia. A generic version of tacrolimus is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Advagraf XL savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.