Advagraf Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx an Advagraf coupon provider?

At NiceRx, we help eligible individuals access patient assistance programs. This means that we are not an Advagraf coupon, an Advagraf discount card, or an Advagraf copay card provider. We do not offer any medication trial offers or free Advagraf samples.

Advagraf patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

Can NiceRx help me get Advagraf cheaper if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Advagraf medication, or if you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Advagraf cost without insurance?

Advagraf costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Advagraf 5 mg capsules will typically cost around $1,300 for 100 capsules.

How much does Advagraf cost with insurance?

The copay of Advagraf will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Advagraf?

Advagraf is a medication manufactured by Astellas Pharma. It is a calcineurin-inhibitor immunosuppressant used for the prophylaxis of organ rejection in kidney transplant patients or liver allograft recipients in combination with other immunosuppressants.

What doses of Advagraf are available?

Advagraf is available as a capsule formulation, in the following doses: 0.5 mg, 1 mg, and 5 mg.

The dose of Advagraf for the prevention of rejection depends on the type of transplant you have received and your body weight. Frequent blood tests will be taken by your doctor to ensure you are taking the correct dose.

Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Advagraf active ingredients

Advagraf contains the active substance tacrolimus. It is classed as an immunosuppressant. Your body’s immune system will try to reject the new organ after your organ transplant. Advagraf will control your body’s response, allowing you to accept the transplanted organ.

Reports documenting mix-ups between Prograf and Advagraf have highlighted concerns about the outcomes of such incidents. Mix-ups have led to serious harm, including biopsy-confirmed acute rejection of transplanted organs and adverse effects due to overexposure.

Other ingredients of Advagraf capsules include hypromellose, ethylcellulose, lactose, and magnesium stearate. The capsule shell contains titanium dioxide, yellow iron oxide, red iron oxide, sodium laurilsulfate, and gelatin.

Advagraf side effects

The most common side effects of Advagraf in clinical trials include:

  • Diarrhea, constipation
  • Nausea
  • Peripheral edema
  • Tremor
  • Anemia
  • Kidney problems
  • Raised blood sugar levels
  • Diabetes
  • Hyperkalaemia (raised blood potassium levels)
  • Hypertension (high blood pressure)
  • Insomnia (difficulty sleeping)

In rare instances, Advagraf can cause more serious side effects. These can include:

  • Increased risk for developing serious infections and malignancies that may lead to hospitalization or death
  • Increased mortality in female liver transplant patients
  • Graft rejection and other serious adverse reactions due to medication errors
  • Nephrotoxicity (acute and/or chronic) – monitor renal function
  • Neurotoxicity
  • QT prolongation
  • Pure red cell aplasia

Your doctor will assess the benefits of using Advagraf against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions to Advagraf to the FDA. Visit, or call 1-800-FDA-1088.

Advagraf drug interactions

Advagraf can interact with other medications. These include:

  • Other medicines used for the prevention of transplant organ rejection – ciclosporin
  • Macrolide antibiotics – telithromycin, erythromycin, clarithromycin
  • Azole antifungals – ketoconazole, fluconazole, itraconazole
  • HIV protease inhibitors – ritonavir, nelfinavir, saquinavir
  • Treatments for stomach ulcers and acid reflux – omeprazole, lansoprazole, or cimetidine
  • Treatments for high blood pressure or heart problems – nifedipine, nicardipine, diltiazem, and verapamil
  • Anticonvulsants – carbamazepine, phenytoin
  • NSAIDs such as ibuprofen
  • Corticosteroids – prednisolone and methylprednisolone
  • St. John’s wort
  • Grapefruit juice

This list is not exhaustive and other prescription drugs may interact with Advagraf.

Advagraf contraindications

You should not use Advagraf if you:

  • Are allergic to the active ingredient tacrolimus
  • Are allergic to sirolimus or to any macrolide-antibiotics such as erythromycin, clarithromycin, or josamycin
  • Are allergic to any of the other ingredients in Advagraf
  • Are pregnant or are planning to become pregnant

Talk to your doctor before using Advagraf if you:

  • Are taking any of the medications that could interact with Advagraf
  • Are receiving treatment for hepatitis C
  • Need to have any vaccinations
  • Are breastfeeding or are planning to breastfeed

Advagraf generic

Advagraf is the trademark brand name for tacrolimus manufactured by Astellas Pharma. A generic version of tacrolimus is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Advagraf savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.