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Advate Patient assistance program

Is your Advate medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Advate medication with our help.

Get started today
  • Secure: Your personal and medical information is safe with us
  • Convenient: We manage the whole process and we’re here to assist you
  • Ongoing refills: We request your medication refills on your behalf
  • Secure: Your personal and medical information is safe with us
  • Convenient: We manage the whole process and we’re here to assist you
  • Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

An introduction to NiceRx

Play video (01:52)
  • An introduction to NiceRx
    (01:52)
  • Next steps after qualifying
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  • Uploading documents and billing
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  • SSN & billing information
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  • Medication delivery time
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How it works

  • Apply Online

    Get started by filling out the online enrollment application to find out if you are eligible.

  • Qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are qualified. The pharmaceutical company provides your medication for free and you only pay our service fee.

  • Upload Documents

    You may be required to submit further information and documents required by the pharmaceutical company which can be securely uploaded online.

  • Application Created

    Your application is created and sent to your doctor for signature. At this stage, you will be billed $49 and will not be billed again until you receive your first medication delivery.

  • Receive Medication

    Your application is sent to the pharmaceutical company. You will be billed again once you receive your medication. We handle the entire ordering process including requesting ongoing refills.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Advate cost savings if eligible

With our assistance, you could access the Advate patient assistance program and obtain your medication for free. We only charge a flat monthly fee of $49 per medication for our services.

Am I eligible for Advate patient assistance?

We review each Advate enrollment application individually to determine if you are eligible. Each assistance program has its own eligibility criteria and the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Advate patient assistance program?

Our process makes it as easy as possible to apply for the Advate patient assistance program. Begin by completing the enrollment application form on our website. Tell us about any medications that you are taking, including Advate, your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers who will supply the medication, so it is important to make sure this information is accurate and up to date.

We will review the information that you have provided to determine whether you are eligible for patient assistance. If we can pre-qualify you for assistance, NiceRx will handle the full enrollment process on your behalf. If you are approved by the pharmaceutical company, you will typically start receiving your medication in 6 – 8 weeks.

Is NiceRx an Advate coupons provider?

NiceRx is not an Advate coupon, Advate discount card, or Advate copay card provider. We do not offer Advate manufacturer coupons, Advate discounts, rebates, Advate savings cards, trial offers, or free Advate samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Can NiceRx help me if I have insurance?

NiceRx may be able to help you if:

  • You have a high copay or coinsurance responsibility for Advate
  • Your insurance company will not pay for your Advate prescription
  • Your healthcare plan does not cover your medication
  • You do not have insurance

Please apply online to find out if we can help you.

How much does Advate cost without insurance?

Without insurance, Advate costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Advate will cost around $914/month.

How much does Advate cost with insurance?

The copay for Advate will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is Advate?

Advate (antihemophilic factor, recombinant) is an FDA-approved medication manufactured by Takeda Pharmaceuticals U.S.A. inc for adults and children (0-16 years of age) with hemophilia A (hemophilia a), which is congenital factor VIII deficiency (fviii). It is used to control and prevent bleeding episodes; for perioperative management; and is used in routine prophylaxis (prophylactic regimen demonstrated In clinical trials) to prevent or reduce the frequency of bleeding episodes. Advate is a medicine used to replace clotting factors (factor VIII or antihemophilic factor). Advate is not used to treat von Willebrand disease.

What doses of Advate are available?

Advate is available as a lyophilized powder in single-use vials containing
human coagulation factor VIII (rDNA) 250, 500, 1000, 1500, 2000, 3000, or 4000 IU.

It is administered via the intravenous route

Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

The dosage and duration of treatment depend on a number of factors including:

  • the severity of factor VIII deficiency
  • the location
  • the extent of the bleeding
  • the patient’s clinical condition

Careful control of replacement therapy is important in cases of major surgery or life-threatening bleeding episodes.

Each single-use vial of Advate has the recombinant factor VIII potency in International Units (IU) stated on the label (250, 500, 1000, 1500, 2000, 3000 or 4000 IU). The expected in vivo peak increase in factor VIII level expressed as IU/dL of plasma or percent of normal can be estimated using the following formulas:

  • IU/dL (or % of normal) = [total dose (IU)/body weight (kg)] × 2 [IU/dL]/[IU/kg]
  • Required dose (International Units) = body weight (kg) × desired factor VIII rise (IU/dL or % of normal) × 0.5 (IU/kg per IU/dL)

Advate can be reconstituted using a pre-packed diluent using the BAXJECT III system (Baxter). This is an easy, one-step activation that eliminates the need to disinfect, as vials are already assembled in the system housing.

Advate can be stored two ways:

  • In a refrigerator at 2 °C TO 8 °C (36 °F TO 46 °F); should not be used beyond the expiration date.
  • At room temperature (up to 30 °C [86 °F]) for up to 6 months, not to exceed the expiration date; the product should not be returned to the refrigerator.

Advate active ingredients

The active ingredient of Advate is Antihemophilic Factor (Recombinant), Plasma/Albumin Free Method.

Advate side effects

The most common side effects caused by Advate include:

  • cough
  • headache
  • joint swelling/aching
  • sore throat
  • fever (pyrexia)
  • itching
  • unusual taste
  • dizziness
  • hematoma
  • abdominal pain
  • hot flashes
  • swelling of legs
  • diarrhea
  • chills
  • runny nose/congestion
  • nausea/vomiting
  • sweating
  • rash

In rare instances, Advate can cause allergic reactions. Call your healthcare professional (HCP) right away. Stop treatment if you experience any of the following symptoms:

  • Rash or hives
  • Itching
  • Tightness of the throat
  • Chest pain or tightness
  • Difficulty breathing
  • Lightheadedness
  • Dizziness
  • Nausea or fainting

Your doctor will assess the benefits of using Advate against your risk of side effects.

Patients are encouraged to report negative side effects or adverse reactions of Advate to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Advate drug interactions

There are 5 disease interactions that occur with Advate. The disease interactions include:

  • cardiovascular complications
  • inhibitory antibodies
  • blood isoagglutinin
  • immunodeficiency
  • thromboembolic events

This list is not exhaustive and other drugs may interact with Advate.

Advate should note be used for women who are breastfeeding.

Advate contraindications

Advate should not be used in patients who have life-threatening hypersensitivity reactions, which includes anaphylaxis, to mouse or hamster protein or other constituents of the product which include mannitol, trehalose, sodium chloride, histidine, Tris, calcium chloride, polysorbate 80, and/or glutathione.

Advate generic

Advate is the trademark brand name for Advate manufactured by Takeda Pharmaceuticals U.S.A. A generic version of Advate is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Advate savings through NiceRx.

Related medications

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking down the different programs and filling out all the required paperwork for each program.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.