medicationsCathflo Activase

Cathflo Activase Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Cathflo Activase cost savings if eligible

If you are eligible to receive your Cathflo Activase prescription through the patient assistance program, your medication will be free. We charge a flat monthly service fee of $49 per medication to cover the cost of our services.

Am I eligible for Cathflo Activase patient assistance?

To be eligible for the Cathflo Activase patient assistance program, you will need to meet specific eligibility criteria set by the pharmaceutical company. At NiceRx, we review each Cathflo Activase enrollment application individually. The main factors considered are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Cathflo Activase patient assistance program?

Applying for the Cathflo Activase patient assistance program through NiceRx is simple. Begin by completing the enrollment application on our website. We will ask for details about your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers that supply your medication. We may be able to help you access patient assistance for other medications as well as Cathflo Activase, so please tell us about any medications that you have been prescribed.

If we determine that you may be eligible for Cathflo Activase assistance, we will handle the full enrollment process on your behalf. We will work with your healthcare provider to prepare and submit all the documents required for you to enroll. If you are successfully enrolled in the Cathflo Activase patient assistance program, we will also request your Cathflo Activase medication refills on your behalf for up to 1 year. At the end of your enrollment period, we will contact you for updated details and seek to re-enroll you in the program.

Is NiceRx a Cathflo Activase coupons provider?

NiceRx does not provide Cathflo Activase coupons, discount cards, or copay cards. We do not offer printable Cathflo Activase manufacturer coupons, Cathflo Activase discounts, rebates, Cathflo Activase savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Cathflo Activase medication with NiceRx.

Can NiceRx help me get Cathflo Activase if I have insurance?

NiceRx may be able to help you access Cathflo Activase patient assistance if:

  • You have a high copay or coinsurance responsibility for Cathflo Activase
  • Your insurance company will not pay for your Cathflo Activase prescription
  • You do not have insurance

Complete your enrollment application online to find out more.

How much does Cathflo Activase cost without insurance?

Cathflo Activase prices without insurance will vary by retailer. As a guide, Cathflo Activase injectable powder for injection 2 mg will typically cost around $170 for 1 powder for injection.

How much does Cathflo Activase cost with insurance?

Your individual healthcare plan will determine the copay of Cathflo Activase with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Cathflo Activase?

Cathflo Activase is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Genentech, Inc.

Cathflo Activase (alteplase) is a tissue plasminogen activator (tPA) indicated for the restoration of function to central venous access devices (CVAD) such as a catheter, as assessed by the ability to withdraw blood.

Cathflo Activase is also used to treat a stroke caused by a blood clot or other obstruction in a blood vessel, to prevent death from a heart attack, or to treat a blood clot in the lung (pulmonary embolism).

What doses of Cathflo Activase are available?

Cathflo Activase is available in lyophilized powder form, in the following doses: 2.2 mg vials in 2mL.

The INS Infusion Therapy Standards of Practice state that the instillation of alteplase 2 mg (Cathflo Activase) is safe and effective in restoring catheter patency in patients. As with all catheterization procedures, care should be used to maintain the aseptic technique.

Cathflo Activase is given as an infusion into a vein. A healthcare provider will give you this injection. After 30 minutes of “dwell time”, catheter function will be assessed by attempting to aspirate blood. When used to clear blood clots from a catheter, Cathflo Activase is given in 1 or 2 doses.

Cathflo Activase is usually given within 3 hours after the first signs of a stroke or heart attack symptoms. Your breathing, blood pressure, oxygen levels, and other vital signs will be monitored closely.

The coadministration of heparin has not been shown to improve the rates of catheter function restoration and is not recommended.

Please see the accompanying full prescribing information for additional Important safety information. and drug information, and always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Reconstitute Cathflo Activase:

  • Aseptically withdraw 2.2 mL of sterile water for injection. Do not use bacteriostatic water for injection
  • Inject the 2.2 mL of sterile water for injection, USP, into the Cathflo Activase vial
  • Mix by gently swirling until the contents are completely dissolved
  • Cathflo Activase contains no antibacterial preservatives and should be reconstituted immediately before use. The solution may be used for intracatheter instillation within 8 hours following reconstitution when stored at 2–30°C

No other medication should be added to solutions containing Cathflo Activase.

Instillation of Solution into the Catheter

  • Inspect the product prior to administration for foreign matter and discoloration
  • Withdraw 2 mL (2 mg) of solution from the reconstituted vial
  • Instill the appropriate dose of Cathflo Activase into the occluded catheter
  • After 30 minutes of dwell time, assess catheter function by attempting to aspirate blood
  • After 120 minutes of dwell time, assess catheter function by attempting to aspirate blood and catheter contents
  • If catheter function is not restored after one dose of Cathflo Activase, a second dose of an equal amount may be instilled
  • If catheter function has been restored, aspirate 4–5 mL of blood in patients ≥10 kg or 3 mL in patients <10 kg to remove Cathflo Activase and residual clot, and gently irrigate the catheter with 0.9% Sodium Chloride Injection, USP

Cathflo Activase active ingredients

Cathflo activase contains the active ingredient alteplase, an enzyme that has the property of fibrin-enhanced conversion of plasminogen to plasmin. Alteplase binds to fibrin in a thrombus and converts the plasminogen to plasmin, thereby initiating local fibrinolysis.

Cathflo Activase side effects

The most common side effects of Cathflo Activase in clinical trials compared to placebo include:

  • Sepsis, venous thrombosis
  • Sudden headache, dizziness
  • Bleeding gums, nosebleeds, easy bruising, bleeding from a wound, incision, catheter, or needle injection
  • Gastrointestinal bleeding, bloody or dark stools, coughing up blood or vomit that looks like coffee grounds
  • Red or pink urine, little or no urination
  • Heavy menstrual periods or abnormal vaginal bleeding
  • Sudden numbness or weakness (especially down one side of the body), slurred speech, problems with vision or balance
  • Chest pain, pain spreading to the jaw or shoulder, nausea, sweating
  • Swelling, rapid weight gain
  • Severe stomach pain, nausea, and vomiting
  • Darkening or purple discoloration of your fingers or toes
  • Very slow heartbeats, shortness of breath
  • Sudden severe back pain, muscle weakness, numbness, or loss of feeling in your arms or legs
  • Increased blood pressure – blurred vision, pounding in your neck or ears, anxiety, nosebleed
  • Pancreatitis – severe pain in your upper stomach spreading to your back, nausea, and vomiting

Your doctor will assess the benefits of using Cathflo Activase against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Cathflo Activase to the FDA. Visit, or call 1-800-FDA-1088.

Cathflo Activase drug interactions

There is currently no data for Cathflo activase interactions with other medications. Tell your healthcare provider about all the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements.

Cathflo Activase contraindications

You should not use Cathflo Activase if you:

  • Are allergic to the active ingredient alteplase
  • Are allergic to any of the other ingredients in Cathflo Activase
  • Have known hypersensitivity to Cathflo Activase or any component of the formulation
  • Have any bleeding inside your body
  • Have a brain tumor or aneurysm
  • Have a history of head injury or surgery on your brain or spinal cord within the past 3 months
  • Have high blood pressure
  • Have a bleeding or blood clotting disorder
  • Have bleeding inside your brain

Talk to your doctor before using Cathflo Activase if you:

  • Are taking any of the medications that could interact with Cathflo Activase
  • Have had any type of stroke
  • Have heart problems
  • Have an infection of the lining of your heart
  • Have a serious injury or major surgery
  • Have severe bruising or infection around a vein where an IV was placed
  • Have an organ biopsy
  • Have eye problems caused by diabetes
  • Have liver or kidney disease
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Cathflo Activase generic

Cathflo Activase is the trademark brand name for alteplase manufactured by Genentech, Inc. A generic version of alteplase is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Cathflo Activase savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.