Lokelma Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Lokelma cost savings if eligible

If you are eligible for the Lokelma patient assistance program, the cost of your medication will be free. We only charge $49 a month, per medication, to cover our service fees. You could receive your Lokelma prescription for just $49 a month, regardless of the retail price of your medication.

Am I eligible for the Lokelma patient assistance program?

We will review your application to determine whether you are eligible for the Lokelma patient assistance program. Each program has its own eligibility criteria which are set by the pharmaceutical companies, however, the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Lokelma patient assistance program?

We make it as easy as possible to apply for the Lokelma patient assistance program. The first step is to complete our enrollment application. Tell us about any medications you are taking, including Lokelma. We will also ask for details about your healthcare provider, insurance, and your household income. This information is required by the pharmaceutical manufacturers who ship your medication.

If we determine that you may be eligible for Lokelma assistance, we will handle the application process for you. We will work directly with your healthcare provider to prepare your application documents. Once we have received the signed application and supporting documents, we will submit them to the patient assistance program on your behalf. Our service continues once you are enrolled in the Lokelma patient assistance program, and we will automatically request your Lokelma medication refills for up to 1 year.

Is NiceRx a Lokelma coupons provider?

We are a service provider that helps eligible individuals access the Lokelma patient assistance program. That means that we do not offer printable Lokelma manufacturer coupons, Lokelma discounts, or free Lokelma samples. We are not a Lokelma coupon provider or Lokelma discount card. Our service extends to assisting eligible individuals to access the medications they need through patient assistance programs.

Can NiceRx help me get Lokelma if I have insurance?

We may be able to help you to access Lokelma patient assistance in a variety of circumstances. This includes when your insurance company will not pay for your Lokelma medication or if you have a high copay or coinsurance responsibility. We may also be able to help you if you do not have insurance. Please apply online to find out more.

How much is Lokelma with insurance?

The cost of Lokelma with insurance depends on the terms of your healthcare plan. To find out how much this is, your healthcare provider or pharmacist will be able to calculate your copay with your current insurance.

How much does Lokelma cost without insurance?

Lokelma prices without insurance will vary depending on where you buy it and how much you buy. As a guide, Lokelma oral powder for reconstitution usually costs $280 for 5 g for 11 powders for reconstitution. With NiceRx you will pay a flat monthly fee of $49, regardless of the retail price of your medication.

What is Lokelma?

Lokelma is an FDA-approved medication manufactured by AstraZeneca. The FDA approval is supported by data from three double-blind, placebo-controlled trials and two open-label trials in adult patients with hyperkalemia. Lokelma is used for the treatment of hyperkalemia (high levels of potassium) in adults. Hyperkalemia is associated with cardiovascular, renal, and metabolic diseases. Lokelma is not absorbed into your bloodstream. It acts directly on the intestines. Lokelma has a delayed onset of action and should not be used for life-threatening hyperkalemia treatment in emergencies.

Lokelma powder needs to be mixed with water before drinking. All of the powder from the packet needs to be used to make sure the correct dose is taken. The dose of Lokelma will need to be adjusted depending on your body serum levels.

Other medicines should be taken 2 hours before or 2 hours after you take this medicine as Lokelma can make it harder for your body to absorb other medicines you take by mouth. Patients receiving chronic hemodialysis should take Lokelma only on non-dialysis days. The recommended starting dose is 5 g once daily on non-dialysis days.

What doses of Lokelma are available?

Lokelma is available in powder form, for oral suspension, in 5 g doses. Each 5 g dose contains approximately 400 mg of sodium.

Always speak with a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Lokelma active ingredients

Lokelma contains the prescription medicine sodium zirconium cyclosilicate. Lokelma is a strong potassium binder and works by replacing hydrogen and sodium for the excess potassium in the body. Lokelma’s mechanism of action is to increase the excretion of potassium in stools from your body by binding with the potassium in the gastrointestinal tract. This mopping up of the excess potassium helps to reduce the amount of potassium that is free in the gastrointestinal tract and therefore helps to lower your serum potassium levels.

Lokelma side effects

The most common side effects and adverse reactions caused by Lokelma included edema (swelling) and hypokalemia (low potassium levels).

Other less common side effects of Lokelma include:

  • Nausea (feeling sick)
  • Vomiting (being sick)
  • Irregular heartbeat
  • Dry mouth, increased thirst, decreased urinating
  • Seizures
  • Feeling tired or weak
  • Loss of appetite
  • Mood changes
  • Muscle pain or cramps, tingling or numb in hands, feet, and lips

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

Lokelma drug interactions

Lokelma can interact with other prescription drugs. These include:

  • Medication to lower your cholesterol – atorvastatin
  • Antifungal medication – itraconazole, ketoconazole, and posaconazole
  • Diuretics such as furosemide
  • Antiviral medication – atazanavir, indinavir, nelfinavir, ritinovir, and saquinavir
  • Medications taken to treat certain types of cancer – dasatinib, erlotinib, and nilotinib
  • Anticoagulants taken to prevent blood clotting – dabigatran

This list is not exhaustive and other drugs may interact with Lokelma.

Lokelma contraindications

You should not use Lokelma if you:

  • Are allergic to the active ingredient sodium zirconium cyclosilicate
  • Are allergic to any of the other ingredients in Lokelma

Talk to your doctor before using Lokelma if you:

  • Are taking any of the medications that could interact with Lokelma
  • Have heart failure or chronic kidney disease (CKD) – hyperkalemia is more likely in patients taking drugs that inhibit the renin-angiotensin-aldosterone system (RAAS)
  • Are on a low-salt diet
  • Have a bowel obstruction, slow digestion, or severe constipation
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Lokelma generic

Lokelma is the trademark brand name for sodium zirconium cyclosilicate manufactured by AstraZeneca. A generic version of Lokelma is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Lokelma savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.