Pristiq Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Have you been prescribed Pristiq and are unable to pay for it? Then try NiceRx. With our help, you may be able to get your Pristiq medication for $49 per month.*

NiceRx works directly with your healthcare provider to help you enroll in patient assistance programs for prescription medications. We’ll handle the full enrollment process for you, helping you get easy and affordable access to the medications you need.

Your monthly Pristiq cost savings if eligible

With our assistance, you could receive your Pristiq prescription for a flat fee of just $49 per month. This is the only fee you will have to pay for your medication, regardless of the retail price. You could save:

StrengthAvg. monthly price at
a US pharmacy
NiceRx monthly
Monthly savings
with NiceRx
100mg 30 tablets$430.00$49.00$381.00
50mg 30 tablets$430.00$49.00$381.00
25mg 30 tablets$430.00$49.00$381.00

Am I eligible for the Pristiq patient assistance program?

At NiceRx, we review every patient assistance program application on an individual basis, with each program defining the eligibility criteria for successful enrollment. The main factors that are considered by most programs include:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Pristiq patient assistance program? 

Begin the process by completing your enrollment application online. At this stage, it’s vital to provide us with relevant and up to date details of any medications you’re taking, including Pristiq. We’ll also ask for details about your healthcare provider, your insurance plan, and your household income, as this information is required by the pharmaceutical manufacturers who ship your medication.

Having fully reviewed the details of your enrollment application, once NiceRx determines that you may be eligible for Pristiq assistance, we’ll handle the full enrollment process for you. When you’re successfully enrolled in the Pristiq patient assistance program, we’ll also request your Pristiq medication refills on your behalf for up to one year.

Is NiceRx a Pristiq coupons provider?

NiceRx is a service provider that helps eligible individuals access the Pristiq patient assistance program. We are not a Pristiq coupon, a Pristiq discount card, or a Pristiq copay card provider. Our service does not include the provision of printable Pristiq manufacturer coupons, Pristiq discounts, rebates, Pristiq savings cards, trial offers, or free Pristiq samples.

If you’re looking for coupons for Pristiq or cheap Pristiq, keep in mind you can likely save more with NiceRx. When obtaining your Pristiq medication through NiceRx, your total cost for the medication will always be $49 per month. You will never be required to pay more than this monthly fee. 

Can NiceRx help me get Pristiq if I have insurance? 

We may be able to assist you  if your insurance company won’t pay for your Pristiq medication, or you have a high copay or coinsurance responsibility. NiceRx may even be able to assist if you don’t have insurance or your Medicare plan doesn’t cover Pristiq. Begin your enrollment application online to find out more.

How much is Pristiq with insurance?

The cost of Pristiq will vary depending on the details of your healthcare plan. To find out exactly what you will need to pay, contact your insurance provider or pharmacist. They will be able to calculate your copay with your current insurance.

How much does Pristiq cost without insurance?

Pristiq prices without insurance will vary depending on the amount and the dose you buy, and where you buy it from. As a guide, a pack of 30, 25 mg Pristiq tablets will cost around $490 to $550.

What is Pristiq?

Pristiq is an antidepressant medication prescribed to adults to treat major depressive disorder. Major depressive disorder, often just called depression, is a common but serious mood disorder. It causes depressive episodes, periods where you experience lasting feelings of sadness, numbness, and a loss of interest in your life.

Pristiq is an antidepressant medication that can help treat your depression. You take it as a tablet you swallow, and it works by increasing levels of natural chemicals that regulate your brain activity. This can reduce the severity of depressive episodes and help keep them at bay.

Pristiq active ingredients

The active ingredient in Pristiq is called desvenlafaxine. It’s a type of antidepressant called a serotonin and norepinephrine reuptake inhibitor (SNRI). When you swallow a Pristiq tablet, it dissolves in your digestive system and releases desvenlafaxine into your bloodstream. Desvenlafaxine is then carried in your blood to your brain, where it slows how quickly you break down two substances called serotonin and norepinephrine.

Serotonin and norepinephrine are natural substances produced in your brain. They’re called neurotransmitters, and they help regulate your brain function by controlling how the nerve cells in your brain communicate with each other. By slowing how quickly serotonin and norepinephrine are broken down, desvenlafaxine causes their levels to increase.

Serotonin and norepinephrine regulate brain function in areas to do with thinking, emotions, mood, learning, reward, alertness, and many more. Research has shown that increasing levels of serotonin and norepinephrine can help reduce the symptoms of depression.

Pristiq side effects & Pristiq drug interactions

The most common side effects caused by Pristiq include:

  • Nausea (feeling sick)
  • Constipation
  • Dizziness
  • Sweating
  • Insomnia (problems falling asleep)
  • Sleepiness 
  • Anxiety
  • Decreased appetite 
  • Sexual problems, like difficulties getting or keeping an erection, and problems reaching climax

In rare instances, Pristiq can cause more serious side effects, including:

  • Severe allergic reactions to the medication
  • An increased risk of suicidal thoughts and suicide, particularly in young adults
  • Serotonin syndrome – a potentially life-threatening condition caused by high levels of serotonin
  • Hyponatremia – low levels of sodium in your blood that can cause serious health problems and death
  • New or worsened hypertension (high blood pressure)
  • Lung problems that can cause discomfort and coughs, and make it difficult to breathe
  • Seizures
  • An increased risk of developing an eye condition called angle-closure glaucoma
  • An increased risk of bruising and bleeding if taken with medications that can reduce blood clotting, like blood thinners, aspirin, or NSAIDs like ibuprofen

Pristiq can interact with other medications including: 

  • Monoamine oxidase inhibitor (MAOI) antidepressants 
  • Any other antidepressants, like tricyclic antidepressants, SSRIs, other SNRIs, or lithium
  • Any other medications containing desvenlafaxine or venlafaxine
  • Any other medications that can affect your serotonin or norepinephrine levels
  • Any other medications taken to treat mental states and conditions, like mood and thought disorders, anxiety, or psychotic disorders
  • Any medications that can reduce blood clotting, like warfarin, aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Medications called triptans, used to migraines
  • Medications containing amphetamines, often used to treat attention deficit hyperactivity disorder (ADHD)
  • Tryptophan
  • Opioid pain medications, like fentanyl or tramadol
  • An herbal supplement called St. John’s Wort

Pristiq warnings & precautions

Antidepressants can increase the risk of suicidal thoughts and suicide in children and young adults, particularly during the first few months of treatment. Pristiq is not for use in children, but young adults taking it should be monitored for signs of sudden changes in behavior, mood, thoughts, or feelings. 

Pristiq can cause side effects, like dizziness, sleepiness, and confusion, that can affect your ability to drive, operate machinery, or perform other dangerous tasks. Don’t do so when taking Pristiq until you’re confident it doesn’t give you these side effects. Don’t drink alcohol while taking Pristiq.

Don’t take Pristiq if you:

  • Are allergic to the active ingredient desvenlafaxine, or to venlafaxine
  • Are allergic to any of the other ingredients in Pristiq (you can find these listed in the leaflet which comes with the medication)
  • Are taking a medication called a monoamine oxidase inhibitor (MAOI), or have taken one in the last 14 days
  • Are taking an antibiotic called linezolid
  • Are being treated with an intravenous medication called methylene blue
  • Are under 18 years of age

Talk to your doctor before taking Pristiq if you:

  • Are taking any of the medications that could interact with Pristiq 
  • Have, or have had, depression, suicidal thoughts, or have ever tried to commit suicide
  • Have, or have any family history, of mania, hypomania, or bipolar disorder
  • Have any heart problems
  • Have previously had a stroke
  • Have any kidney problems
  • Have any liver problems
  • Have hypertension (high blood pressure)
  • Have high cholesterol or high triglycerides (blood fats)
  • Have low blood sodium levels
  • Have, or have had, any bleeding problems
  • Have ever had a seizure
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.