Syprine Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Syprine cost savings if eligible

If you are eligible to receive your Syprine prescription through the patient assistance program, your medication will be free. We charge a flat monthly service fee of $49 per medication to cover the cost of our services.

Am I eligible for Syprine patient assistance?

To be eligible for the Syprine patient assistance program, you will need to meet specific eligibility criteria set by the pharmaceutical company. At NiceRx, we review each Syprine enrollment application individually. The main factors considered are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Syprine patient assistance program?

Applying for the Syprine patient assistance program through NiceRx is simple. Begin by completing the enrollment application on our website. We will ask for details about your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers that supply your medication. We may be able to help you access patient assistance for other medications as well as Syprine, so please tell us about any medications that you have been prescribed.

If we determine that you may be eligible for Syprine assistance, we will handle the full enrollment process on your behalf. We will work with your healthcare provider to prepare and submit all the documents required for you to enroll. If you are successfully enrolled in the Syprine patient assistance program, we will also request your Syprine medication refills on your behalf for up to 1 year. At the end of your enrollment period, we will contact you for updated details and seek to re-enroll you in the program.

Is NiceRx a Syprine coupons provider?

NiceRx does not provide Syprine coupons, discount cards, or copay cards. We do not offer printable Syprine manufacturer coupons, Syprine discounts, rebates, Syprine savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Syprine medication with NiceRx.

Can NiceRx help me get Syprine if I have insurance?

NiceRx may be able to help you access Syprine patient assistance if:

  • You have a high copay or coinsurance responsibility for Syprine
  • Your insurance company will not pay for your Syprine prescription
  • You do not have insurance

Complete your enrollment application online to find out more.

How much does Syprine cost without insurance?

Syprine prices without insurance will vary by retailer. As a guide, Syprine oral capsules 250 mg will typically cost around $22,200 for 100 capsules.

How much does Syprine cost with insurance?

Your individual healthcare plan will determine the copay of Syprine with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Syprine?

Syprine is an FDA (U.S. Food and Drug Administration) approved medication distributed by Bausch Health US. Syprine is a chelating agent that works by removing heavy metals such as lead, mercury, or copper from the blood.

Wilson’s disease is a genetic defect that causes excess copper to build up in your body. Syprine is used to treat this condition in people who cannot take penicillamine. Unlike penicillamine, Syprine is not recommended in cystinuria or rheumatoid arthritis.

What doses of Syprine are available?

Syprine is available in capsule form, in the following doses: 250 mg.

Syprine should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal. Do not drink milk, eat food, or take any other medications for at least 1 hour after you take Syprine. Do not chew, break, or open the capsule.

Call your doctor if you have symptoms of a fever or a skin rash while taking this medicine. You may need to take your temperature every night for the first month of treatment with Syprine. You may need regular blood and urine tests while using Syprine.

Always speak with a healthcare professional for medical advice or about any changes to your dose so they can monitor and evaluate your condition.

Syprine active ingredients

Syprine contains the active ingredient trientine hydrochloride.

Syprine side effects

The most common side effects of Syprine in clinical trials include:

  • Heartburn, stomach pain, loss of appetite
  • Dark, tarry stools
  • Mouth sores
  • Skin flaking, cracking, or thickening

In rare instances, Syprine can cause more serious adverse effects. These can include:

  • Fever or skin rash
  • Problems with speech, balance, walking, lifting, chewing, or swallowing
  • Muscle pain or stiffness, muscular spasm, myasthenia gravis
  • Double vision
  • Systemic lupus erythematosus – joint pain or swelling, headaches, confusion, chest pain, shortness of breath, skin sores, or numbness, feeling cold, or pale appearance of your fingers or toes
  • Iron-deficiency anemia

Your doctor will assess the benefits of using Syprine against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Syprine to the FDA. Visit, or call 1-800-FDA-1088.

Syprine drug interactions

Syprine can interact with other medications. These include:

  • Iron and Syprine each inhibit the absorption of the other – two hours should elapse between administration of Syprine and iron

    It is important that Syprine be taken on an empty stomach, at least one hour before meals or two hours after meals, and at least one hour apart from any other drug, food, or milk. This allows maximum absorption and reduces the chance of inactivation of the drug by metal binding in the gastrointestinal tract

This list is not exhaustive and other prescription drugs may interact with Syprine. Tell your doctor about all other medicines (prescription drugs and over-the-counter, including vitamins, herbal or mineral supplements that you are taking.

Syprine contraindications

You should not use Syprine if you:

  • Are allergic to the active ingredient trientine
  • Have had an allergic reaction to any of the other ingredients in Syprine

Talk to your doctor before using Syprine if you:

  • Are taking any of the medications that could interact with Syprine
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed
  • Have anemia (low red blood cells)
  • Have a liver condition called biliary cirrhosis

Syprine generic

Syprine is the trademark brand name for trientine distributed by Bausch Health US. A generic version of trientine is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Syprine savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.