Zortress Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Zortress cost savings if eligible

If you are eligible to receive your Zortress prescription through the patient assistance program, your medication will be free. We charge a flat monthly service fee of $49 per medication to cover the cost of our services.

Am I eligible for Zortress patient assistance?

To be eligible for the Zortress patient assistance program, you will need to meet specific eligibility criteria set by the pharmaceutical company. At NiceRx, we review each Zortress enrollment application individually. The main factors considered are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Zortress patient assistance program?

Applying for the Zortress patient assistance program through NiceRx is simple. Begin by completing the enrollment application on our website. We will ask for details about your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers that supply your medication. We may be able to help you access patient assistance for other medications as well as Zortress, so please tell us about any medications that you have been prescribed.

If we determine that you may be eligible for Zortress assistance, we will handle the full enrollment process on your behalf. We will work with your healthcare provider to prepare and submit all the documents required for you to enroll. If you are successfully enrolled in the Zortress patient assistance program, we will also request your Zortress medication refills on your behalf for up to 1 year. At the end of your enrollment period, we will contact you for updated details and seek to re-enroll you in the program.

Is NiceRx a Zortress coupons provider?

NiceRx does not provide Zortress coupons, discount cards, or copay cards. We do not offer printable Zortress manufacturer coupons, Zortress discounts, rebates, Zortress savings cards, trial offers, or free samples. We are a service provider that helps eligible individuals access patient assistance programs. Our service cost is $49 a month per medication, so you will likely save more on your Zortress medication with NiceRx.

Can NiceRx help me get Zortress if I have insurance?

NiceRx may be able to help you access Zortress patient assistance if:

  • You have a high copay or coinsurance responsibility for Zortress
  • Your insurance company will not pay for your Zortress prescription
  • You do not have insurance

Complete your enrollment application online to find out more.

How much does Zortress cost without insurance?

Zortress prices without insurance will vary by retailer. As a guide, Zortress oral tablets 0.25 mg will typically cost around $590 for a supply of 60 tablets.

How much does Zortress cost with insurance?

Your individual healthcare plan will determine the copay of Zortress with insurance. To find out what you will need to pay, contact your pharmacist or insurance provider. They will be able to calculate your copay with your current insurance.

What is Zortress?

Zortress is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Novartis Pharmaceuticals Corporation.

Zortress is used for the prophylaxis of organ rejection in adult patients:

  • Kidney transplant – at low to moderate immunologic risk. Use in combination with basiliximab, cyclosporine, and corticosteroids
  • Liver transplant – administer no earlier than 30 days post-transplant. Use in combination with tacrolimus (reduced doses) and corticosteroids

The safety and efficacy have not been established in the following:

  • Kidney transplant patients at high immunologic risk
  • Recipients of transplanted organs other than kidney or liver
  • Pediatric patients (<18 years)

Warning – Malignancies and serious infections, kidney graft thrombosis, nephrotoxicity, and mortality in heart transplantation. See the full prescribing information for a complete boxed warning.

  • Only physicians experienced in immunosuppressive therapy and management of transplant patients should use Zortress
  • Increased susceptibility to infection and the possible development of malignancies may result from immunosuppression
  • Increased incidence of kidney graft thrombosis
  • Reduced doses of cyclosporine are required for use in combination with Zortress in order to reduce nephrotoxicity
  • Increased mortality in a heart transplant clinical trial – use in heart transplantation is not recommended

What doses of Zortress are available?

Zortress is available in tablet form, in the following doses: 0.25 mg, 0.5 mg, and 0.75 mg tablets.

  • Kidney transplantation – starting dose of 0.75 mg twice daily as soon as possible after transplantation
  • Liver transplantation – starting dose of 1.0 mg twice daily starting 30 days after transplantation

Monitor everolimus concentrations, adjust the maintenance dose to achieve trough concentrations within the 3-8 ng/mL target range. Administer consistently with or without food at the same time as cyclosporine or tacrolimus.

  • Mild hepatic impairment – reduce the initial daily dose by one-third. Moderate or Severe hepatic impairment – reduce initial daily dose by one-half

Always speak with a healthcare professional for medical advice or about any changes to your dose so they can monitor and evaluate your condition.

Zortress active ingredients

Zortress contains the active ingredient everolimus.

Zortress side effects

The most common side effects of Zortress in clinical trials include:

  • Peripheral edema
  • Constipation
  • Hypertension (high blood pressure)
  • Nausea
  • Anemia
  • Urinary tract infections
  • Hyperlipidemia
  • Diarrhea
  • Headache
  • Pyrexia
  • Abdominal pain
  • Leukopenia

In rare instances, Zortress can cause more serious side effects. These can include:

  • Angioedema – increased risk with concomitant ACE inhibitors)
  • Delayed wound healing/fluid accumulation
  • Interstitial lung disease/non-infectious pneumonitis – consider the use of corticosteroids
  • Hyperlipidemia – increase in serum cholesterol and triglycerides – monitor and consider anti-lipid therapy
  • Proteinuria
  • Increased risk of infection due to a weakened immune system – activation of latent viral infections, virus-associated nephropathy, development of malignancies such as lymphoma and skin cancer may result from immunosuppression
  • New-onset diabetes after transplantation
  • Male infertility

Your doctor will assess the benefits of using Zortress against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Zortress to the FDA. Visit, or call 1-800-FDA-1088.

Zortress drug interactions

Zortress can interact with other medications. These include:

  • Strong-moderate CYP3A4 inhibitors – cyclosporine, ketoconazole, erythromycin, verapamil, St. John’s Wort
  • CYP3A4 inducers – rifampin
  • Clinical studies of Zortress with cyclosporine conducted in kidney transplant patients strongly discouraged patients with receiving HMG-CoA reductase inhibitors such as simvastatin and lovastatin
  • Avoid live vaccines
  • Grapefruit and grapefruit juice inhibit cytochrome P450 3A4 and P-gp activity and should therefore be avoided

This list is not exhaustive and other prescription drugs may interact with Zortress. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Zortress contraindications

You should not use Zortress if you:

  • Are allergic to the active ingredient everolimus
  • Have had hypersensitivity to everolimus, sirolimus, or to components of the drug product
  • Are pregnant or are planning to become pregnant – if you are able to become pregnant you should use effective birth control during treatment and for 8 weeks after your last dose
  • Are breastfeeding or are planning to breastfeed

Talk to your doctor before using Zortress if you:

  • Are taking any of the medications that could interact with Zortress

Zortress generic

Zortress is the trademark brand name for everolimus manufactured by Novartis Pharmaceuticals Corporation. A generic version of everolimus is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Zortress savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.