Zynteglo Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx a Zynteglo coupon provider?

NiceRx is not a Zynteglo coupon, Zynteglo discount card, or Zynteglo copay card provider. We do not offer Zynteglo manufacturer coupons, Zynteglo discounts, rebates, Zynteglo savings cards, trial offers, or free Zynteglo samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Zynteglo patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

How much does Zynteglo cost without insurance?

Without insurance, Zynteglo costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Zynteglo will cost around $2.1 million per treatment according to the manufacturer.

How much does Zynteglo cost with insurance?

The copay for Zynteglo will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is Zynteglo?

Zynteglo is an FDA (U.S. Food and Drug Administration) approved one-time gene therapy manufactured by Bluebird Bio, Inc. It is a treatment option that gained FDA approval on August 17, 2022, for adults and pediatric patients 4 years and older with transfusion-dependent beta-thalassemia (TDT) who require regular red blood cell transfusions. It is only approved in TDT patients who do not have a β0/β0 genotype.

Beta-thalassemia is an inherited blood disorder that causes a reduction of normal hemoglobin and red blood cells in the blood, through mutations in the beta-globin gene, leading to reduced levels of oxygen in the body. This can lead to dizziness, weakness, fatigue, and bone abnormalities.

Zynteglo is only available at Qualified Treatment Centers (QTCs), based on their experience in stem cell transplantation, cell and gene therapy, and beta-thalassemia. It is a lentiviral vector gene therapy, where each dose is created using the patient’s own genetically modified bone marrow stem cells to produce functional beta-globin. Zynteglo can help patients achieve transfusion independence where they maintain a sufficient level of hemoglobin without any RBC transfusions for at least a year.

What doses of Zynteglo are available?

Zynteglo is available as a cell suspension for IV infusion. It contains a minimum of 5x 10^6 CD34+ cells/kg of body weight.

Zynteglo active ingredients

The active ingredient of Bluebird Bio’s gene therapy Zynteglo is betibeglogene autotemcel (beti-cel). It adds functional copies of a modified β-globin gene into the patient’s hematopoietic stem cells (HSCs).

Zynteglo side effects

The most common side effects of Zynteglo in clinical trials include:

  • Mucositis (swelling and irritation in the mouth)
  • Vomiting
  • Pyrexia (fever)
  • Alopecia (hair loss)
  • Nosebleed
  • Abdominal pain
  • Musculoskeletal pain
  • Cough
  • Headache
  • Diarrhea
  • Rash
  • Pruritus (itching)
  • Nausea
  • Constipation
  • Decreased appetite

In rare instances, Zynteglo can cause more serious side effects. These can include:

  • Allergic reaction
  • Anemia
  • Increased risk of blood cancer
  • Reduced platelet count

Your doctor will assess the benefits of using Zynteglo against your risk of side effects.

Patients are encouraged to report negative side effects or adverse reactions from Zynteglo to the FDA. Visit, or call 1-800-FDA-1088.

Zynteglo drug interactions

Zynteglo can interact with other medications. These include:

  • Live vaccines
  • Anti-retrovirals
  • Hydroxyurea
  • Iron chelators

This list is not exhaustive and other prescription drugs may interact with Zynteglo.

Zynteglo contraindications

You should not use Zynteglo if you:

  • Are allergic to the active ingredient Zynteglo
  • Are allergic to any of the other ingredients in Zynteglo
  • Are pregnant, planning to become pregnant, or are breastfeeding

Talk to your doctor before using Zynteglo if you:

  • Have a bleeding disorder or are on blood thinners

Zynteglo generic

Zynteglo is the trademark brand name that is manufactured by Bluebird Bio, Inc. A generic version of Zynteglo is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Zynteglo savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.