- As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
$49 per month
- Adults and children 10 years or older with Type 2 diabetes mellitus
Drug facts and comparison
You should not use Januvia if you:
You should talk to your doctor before using Januvia if you:
You should not use Metformin if you:
You should talk to your doctor before using Metformin if you:
Once, twice or three times a day
30, 100 mg Januvia tablets will cost around $625
14, 500 mg Metformin oral tablets will cost $11
Januvia is a brand-name prescription drug manufactured by Merck. It is known as a dipeptidyl peptidase 4 inhibitor (DPP-4 inhibitor) used in diabetes treatment to control blood glucose levels in type 2 diabetes mellitus. metformin is the name of a generic drug and is one of the earliest medications for diabetes. It belongs to the biguanides class of drugs and is used regularly as a first-line treatment for type 2 diabetes. Januvia is not available in a generic form and is considerably more expensive, while metformin is affordable for most patients.
Both drugs are U.S. Food and Drug Administration (FDA) approved and are included in the American Diabetes Association guidelines. These drugs can be used separately or together to gain glycemic control in diabetes patients. There is also a third option of using these drugs in a combination product called Janumet. Let us take a look at the differences and similarities between Januvia and metformin.
Januvia and metformin are diabetes medicines to treat type 2 diabetes and can not be used to treat type 1 diabetes. What is type 2 diabetes?
In type 2 diabetes you do produce insulin, but the body can not use it effectively. There is usually a combination of a part failure of insulin production and a reduced response to the hormone. This is known as insulin resistance. Research does not give us a clear idea why some people develop this and others don’t, but lifestyle factors, e.g. lack of exercise and excess body weight can contribute to type 2 diabetes.
The first treatment recommended for type 2 diabetes is typically lifestyle changes, such as losing excess weight, getting regular exercise, and eating a healthier diet. If lifestyle changes do not work, then you may be prescribed medications to help lower your blood glucose. Most medications for type 2 diabetics are oral drugs like Januvia and metformin however, a few come as injections. Some people with type 2 diabetes may also need to use insulin.
Having diabetes means that glucose builds up in your bloodstream to a dangerous level. If this level is not reduced by medication and lifestyle changes eventually the body will be damaged. High blood sugar levels can cause a range of problems over time, including nerve damage, heart disease, strokes, and kidney failure.
Metformin is also used to treat polycystic ovaries and weight gain due to medications used for treating psychoses. Januvia is not indicated for this treatment.
In a 24-week clinical trial, both Januvia and metformin led to similar improvements in A1c levels in patients with type 2 diabetes. Although both treatments were generally well-tolerated, the incidence of gastrointestinal-related side effects was significantly lower with Januvia (11.6%) compared with metformin (20.7%).
Januvia is a prescription medicine used for
Januvia is taken as a pill that’s swallowed, usually once a day in the following doses: 25 mg, 50 mg, and 100 mg.
Januvia treats type 2 diabetes by helping to lower your blood sugar levels. It encourages your pancreas to produce insulin for longer after you’ve eaten, helping your body absorb more sugar out of your blood.
The active ingredient in Januvia is called sitagliptin. It works by increasing the amount of insulin you produce after you’ve eaten.
When you digest food, your stomach and gut produce digestive hormones called glucagon-like peptide-1 (GLP-1) and GIP. These hormones make your pancreas secrete insulin. As you continue to digest your food, the digestive hormones are broken down by an enzyme called dipeptidyl peptidase-4 (DPP-4) to allow your levels of insulin to fall again.
Sitagliptin stops the DPP-4 enzyme from breaking down the digestive hormones. This keeps the hormones active for longer, making you produce more insulin, and lowering your blood sugar to normal levels.
The most common side effects caused by Januvia include
In rarer cases, Januvia can cause more serious side effects like
If you take Januvia you could experience side effects, including the most serious, but everyone reacts differently to medication. If you have any concerns about side effects, talk to your physician or a pharmacist.
Certain medications can interact with each other, affecting how they work and making some side effects more likely. Medications that are known or thought to interact with Januvia include:
Don’t take Januvia if you:
Talk to your doctor before taking Januvia if you:
Metformin works in three ways:
Metformin is a very useful drug in that it reduces high blood sugar but does not cause hypoglycemia in patients with type 2 diabetes who are not using insulin injections. It can do this because it does not increase your insulin production like many other diabetes medications.
The most common side effects of metformin include:
In rare instances, metformin can cause more serious side effects, including:
Metformin can also interact with the following medications:
Give a complete list of all the prescription drugs, including over-the-counter meds, supplements, and medical conditions you may have to your healthcare provider. Talking with your doctor will allow them to pick up any drug interactions with metformin and help manage any possible side effects.
Don’t take metformin if you:
Talk to your doctor before taking metformin if you:
Read the full prescribing information for Januvia and metformin and always speak with your healthcare provider for medical advice about your medicine so they can monitor and evaluate your condition. Always inform your healthcare provider of all medical conditions, and medications taken including over-the-counter meds and supplements. You are encouraged to report the adverse side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.