comparePancreaze vs Creon

Pancreaze vs Creon

Drug facts and comparison

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Medically reviewed by  Jamie Winn, PharmD

Uses

Treatment of exocrine pancreatic insufficiency (EPI) due to cystic fibrosis or other conditions

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  • Treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions
Get Creon for only
$49 per month
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Summary

Brand name: Pancreaze
Brand name: Creon
Manufacturer: McNeil Pediatrics
Manufacturer: Abbott Laboratories
Active ingredient: pancrelipase
Active ingredient: pancrelipase
Indication: Treatment of exocrine pancreatic insufficiency (EPI) due to cystic fibrosis or other conditions
Indication: Treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions

Side Effects

Most common:

  • Abdominal pain
  • Flatulence, diarrhea, abnormal feces
  • Fatigue

More serious:

  • Fibrosing colonopathy
  • Irritation of oral mucosa
  • Risk of viral transmission with all pancreatic enzyme products

Most common

  • Stomach pain
  • Flatulence and bloating
  • Frequent or abnormal bowel movements
  • Vomiting
  • Dizziness
  • Increases in blood sugar
  • Decreases in blood sugar

More serious

  • Severe allergic reactions to the medication
  • A rare bowel disorder called fibrosing colonopathy
  • An increase in blood uric acid levels that can cause joint swelling and pain (gout)
  • Irritation of the inside of your mouth if Creon is not swallowed properly

Drug Interactions

Severe interactions

No severe interactions

Serious interactions

No serious interactions

Moderate interactions

No moderate interactions

Severe interactions
  • No severe interactions
Serious interactions
  • Calcium carbonate
  • Ferrous fumarate, ferrous gluconate, ferrous sulfate
  • Folic acid
  • Multivitamin with iron, multivitamin with iron and fluoride, multivitamin with minerals, multivitamin, prenatal
  • Sodium bicarbonate
Moderate interactions
  • No moderate interactions

Warnings

You should not take Pancreaze if you:

  • Are allergic to pork (pig) products
  • Are allergic to any of the other ingredients in Pancreaze

You should talk to your doctor before using Pancreaze if you:

  • Are taking any of the medications that could interact with Pancreaze
  • Have a history of blockage of your intestines, scarring or thickening of your bowel wall (fibrosing colonopathy)
  • Have gout, kidney disease, or high blood uric acid (hyperuricemia)
  • Have difficulty swallowing capsules
  • Are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed. It is not known if Pancreaze passes into your breast milk

You should not use Creon if you:

  • Are allergic to pork proteins
  • Are allergic to any of the other ingredients in Creon

You should talk to your doctor before using Creon if you:

  • Have or have ever had fibrosing colonopathy
  • Have or have ever had any intestinal blockages
  • Have kidney disease
  • Have gout
  • Have high blood uric acid
  • Have problems swallowing capsules
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Dosage

As prescribed by your doctor

Based on age and body weight

Cost

100 Pancreaze delayed release capsules (2600 units-15,200 units-8800 units) will cost around $90

90, high-strength Creon capsules will cost around $900

FAQs

Pancreaze and Creon are brand names for prescription drugs used for the treatment of pancreatic enzyme replacement therapy due to medical conditions such as cystic fibrosis.

Here we will explain how they work, their similarities and differences, their side effects, and more. This should provide you with the basics to better understand your options.

What is Pancreaze?

Pancreaze is an FDA-approved (U.S. Food and Drug Administration) medication manufactured by McNeil Pediatrics. It is used for the treatment of exocrine pancreatic insufficiency (EPI) due to cystic fibrosis or other conditions. Pancreaze contains pancrelipase a combination of porcine lipases, proteases, and amylases. It belongs to a class of drugs called pancreatic/digestive enzymes.

Pancreaze works by replacing pancreatic enzymes. It helps to break down starches into dextrins, maltose, and maltotriose, fats into monoglycerides, glycerol, free fatty acids, and proteins into peptides and amino acids in the duodenum and proximal small intestine.

Pancreaze dosage

Pancreaze is available as a delayed-release capsule dosage form, in the following doses:

  • 4,200 USP units of lipase; 10,000 USP units of protease; 17,500 USP units of amylase
  • 10,500 USP units of lipase; 25,000 USP units of protease; 43,750 USP units of amylase
  • 16,800 USP units of lipase; 40,000 USP units of protease; 70,000 USP units of amylase
  • 21,000 USP units of lipase; 37,000 USP units of protease; 61,000 USP units of amylase

Pancreaze can not be swapped for any other pancrelipase product. The dose given will be based on your age, and body weight, but should not exceed the recommended maximum dose recommended by the Cystic Fibrosis Foundation Consensus Conferences Guidelines. Pancreaze capsules should be swallowed whole. Patients that are not able to swallow capsules, may open the capsule and sprinkle the contents on applesauce before consuming.

Read the full prescribing information and always speak to a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

What is Creon?

Creon is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Abbott Laboratories. Creon is a type of pancreatic enzyme replacement therapy (PERT) used to help improve digestion by breaking down fats, starches, and proteins in your food. It is a combination of porcine-derived lipases, proteases, and amylases. It can treat conditions such as cystic fibrosis, chronic pancreatitis, pancreatectomy, and pancreatic cancer where your pancreas does not produce or release enough enzymes.

Creon releases high levels of lipase, amylase, and protease into the duodenum following activation by its alkaline pH. This facilitates the breakdown of fats into glycerol and free fatty acids, starches into dextrins and sugars, and proteins into amino acids and peptides. The effectiveness of Creon is dependent on several factors such as the dose, your gastrointestinal pH, and the microsphere size of the medication.

Creon dosage

Creon is available as a delayed-release capsule formulation, in the following doses:

  • 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase
  • 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase
  • 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase

Your dose will be based on your body weight or the number of fatty foods you eat. Do not switch Creon with other pancreatic enzyme products without talking to your doctor. Take Creon with a meal or snack, but make sure you don’t go over your total daily dose.

Patients that are not able to swallow capsules, may open the capsule and sprinkle the contents on applesauce before consuming. Drink water or juice to be sure there is no Creon left in the mouth.

Read the full prescribing information and always speak to a healthcare professional about any changes to your dose so they can monitor and evaluate your condition.

Common side effects of Pancreaze and Creon

The most common side effects of Pancreaze in clinical trials include:

  • Abdominal pain
  • Flatulence, diarrhea, abnormal feces
  • Fatigue

More serious side effects of Pancreaze include:

  • Fibrosing colonopathy
  • Irritation of oral mucosa
  • Risk of viral transmission with all pancreatic enzyme products

The most common side effects of Creon can include:

  • Abdominal pain
  • Headache
  • Hyperglycemia
  • Hypoglycemia
  • Bloating
  • Flatulence
  • Vomiting
  • Frequent bowel movements
  • Constipation
  • Dizziness
  • Cough
  • Sore throat
  • Weight loss

Some serious side effects of Creon include:

  • Fibrosing colonopathy (scarring of your colon)
  • Increase in uric acid levels
  • Viral infection
  • Allergic reactions (hives, face swelling, throat tightness, difficulty breathing)

These aren’t all the side effects Pancreaze or Creon can cause. You can find more details in the patient leaflet that comes with your medication. If you have any concerns about side effects, talk to your physician or pharmacist.

Pancreaze and Creon drug interactions

While no drug interactions of Pancreaze or Creon have been identified, you should make sure your doctor is aware of all the medications you take, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements.

Pancreaze and Creon contraindications

You should not use Pancreaze if you:

  • Are allergic to pork (pig) products
  • Are allergic to any of the other ingredients in Pancreaze

Talk to your doctor before using Pancreaze if you:

  • Are taking any of the medications that could interact with Pancreaze
  • Have a history of blockage of your intestines, scarring or thickening of your bowel wall (fibrosing colonopathy)
  • Have gout, kidney disease, or high blood uric acid (hyperuricemia)
  • Have difficulty swallowing capsules
  • Are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed. It is not known if Pancreaze passes into your breast milk

You should not use Creon if you:

  • Are allergic to pork or any pig products
  • Have known hypersensitivity to Creon or any of its inactive ingredients

Talk to your doctor before using Creon if you:

  • Have or have ever had fibrosing colonopathy
  • Have or have ever had any intestinal blockages
  • Have kidney disease
  • Have gout
  • Have high blood uric acid (hyperuricemia)
  • Have problems swallowing capsules
  • Are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed

Other drugs for the treatment of pancreatic enzyme replacement therapy

  • Zenpep
  • Viokace
  • Pertzye
  • Lactaid
  • Ultresa

If you have any concerns about Pancreaze or Creon side effects, talk to your physician, or pharmacist for medical advice. Also inform your healthcare provider about any medical conditions, supplements, and over-the-counter meds you are taking. You are also encouraged to report side effects to the FDA: visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.
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