Home / Medications / Compare Drugs / Zenpep vs Creon

Zenpep vs Creon

Drug facts and comparison

✅
Medically reviewed by  Jamie Winn, PharmD

Uses

  • Treatment of exocrine pancreatic insufficiency due to cystic fibrosis, or other conditions
Get Zenpep for only
$49 per month
Get started
  • Treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions
Get Creon for only
$49 per month
Get started

Summary

Brand name: Zenpep
Brand name: Creon
Manufacturer: Eurand Pharmaceuticals, Inc.
Manufacturer: Abbott Laboratories
Active ingredient: pancrelipase
Active ingredient: pancrelipase
Indication: Treatment of exocrine pancreatic insufficiency due to cystic fibrosis, or other conditions
Indication: Treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions

Side Effects

Most common

  • Stomach pain
  • Flatulence
  • Headaches
  • Cough
  • Decreased weight

More serious

  • Deterioration of the symptoms of gout
  • Allergic reactions
  • Fibrosing colonopathy (rare bowel disorder)

Most common

  • Stomach pain
  • Flatulence and bloating
  • Frequent or abnormal bowel movements
  • Vomiting
  • Dizziness
  • Increases in blood sugar
  • Decreases in blood sugar

More serious

  • Severe allergic reactions to the medication
  • A rare bowel disorder called fibrosing colonopathy
  • An increase in blood uric acid levels that can cause joint swelling and pain (gout)
  • Irritation of the inside of your mouth if Creon is not swallowed properly

Drug Interactions

Severe interactions
  • No severe interactions
Serious interactions
  • Calcium carbonate
  • Ferrous fumarate, ferrous gluconate, ferrous sulfate
  • Folic acid
  • Multivitamin with iron, multivitamin with iron and fluoride, multivitamin with minerals, multivitamin, prenatal
  • Sodium bicarbonate
Moderate interactions
  • No moderate interactions
Severe interactions
  • No severe interactions
Serious interactions
  • Calcium carbonate
  • Ferrous fumarate, ferrous gluconate, ferrous sulfate
  • Folic acid
  • Multivitamin with iron, multivitamin with iron and fluoride, multivitamin with minerals, multivitamin, prenatal
  • Sodium bicarbonate
Moderate interactions
  • No moderate interactions

Warnings

You should not use Zenpep if you:

  • Are allergic to pork proteins
  • Are allergic to any of the other ingredients in Zenpep

You should talk to your doctor before using Zenpep if you:

  • Have kidney disease
  • Have gout or high blood uric acid
  • Have ever had a blockage in your intestines
  • Have problems swallowing tablets
  • Have ever had scarring or thickening of your bowel wall (fibrosing colonopathy)
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

You should not use Creon if you:

  • Are allergic to pork proteins
  • Are allergic to any of the other ingredients in Creon

You should talk to your doctor before using Creon if you:

  • Have or have ever had fibrosing colonopathy
  • Have or have ever had any intestinal blockages
  • Have kidney disease
  • Have gout
  • Have high blood uric acid
  • Have problems swallowing capsules
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Dosage

Based on age and body weight

Based on age and body weight

Cost

100, lowest strength delay-released Zenpep capsules will cost around $200

90, high-strength Creon capsules will cost around $900

FAQs

Zenpep and Creon are brand names for porcine-derived pancreatic enzyme products (PEP) used as pancreatic enzyme replacement therapy.

Here we will explain how they work, their similarities and differences, their side effects, and more. This should provide you with the basics to better understand your options.

What is Zenpep?

Zenpep is an FDA-approved (U.S. Food and Drug Administration) medication manufactured by Eurand Pharmaceuticals, Inc. It is a pancreatic enzyme product for the treatment of exocrine pancreatic insufficiency (EPI) associated with cystic fibrosis (CF).

Cystic fibrosis is a genetic disorder that makes your body produce fluids, like mucus, sweat, and digestive juices that are too thick. Over time this disrupts and damages parts of your body, usually your lungs, liver and kidneys, pancreas, and your digestive system. The disorder can interfere with food digestion by affecting your pancreas and causing a condition called exocrine pancreatic insufficiency. Your pancreas produces digestive enzymes, which are substances that help your digestive system break down food. Thick mucus in your pancreas can block these enzymes from entering your digestive system, making it harder for you to digest food.

EPI can cause gastrointestinal problems, such as stomach cramps, bloating, pain, flatulence, and diarrhea. Problems digesting food can also mean you don’t get the calories and the nutrition you need to be healthy. It can lead to weight loss and fatigue, as well as conditions caused by dietary deficiencies like anemia, bleeding disorders, or metabolic bone disease. Zenpep helps with EPI by improving your ability to digest food. The medication contains a mixture of digestive enzymes that can help top-up the enzymes you’re lacking, allowing you to digest food normally.

The active ingredient in Zenpep is called pancrelipase. Pancrelipase is a mixture of three groups of digestive enzymes called amylases, lipases, and proteases. These enzymes are derived from the pancreases of pigs, but they are safe and effective for children and adults to use. Once in your digestive system, they help your body break down and absorb the proteins, carbohydrates, sugars, and fats in your food.

Zenpep dosage

Zenpep is available in a delayed-release capsule formulation, in the following doses:

  • 5,000 USP units of lipase, 17,000 USP units of protease, 27,000 USP units of amylase
  • 10,000 USP units of lipase, 34,000 USP units of protease, and 55,000 USP units of amylase
  • 15,000 USP units of lipase, 51,000 USP units of protease, and 82,000 USP units of amylase
  • 20,000 USP units of lipase, 68,000 USP units of protease, and 109,000 USP units of amylase

Zenpep is not interchangeable with any other pancrelipase product.

  • Infants (up to 12 months) – 2,000 to 4,000 lipase units per 120 mL of formula or per breast-feeding
  • Children older than 12 months and younger than 4 years – initiate with 1,000 lipase units/kg of body weight per meal up to a maximum of 2,500 lipase units/kg of body weight per meal, or less than 4,000 lipase units/g fat ingested per day
  • Children 4 years and older and adults – begin with 500 lipase units/kg of body weight per meal to a maximum of 2,500 lipase units/kg of body weight per meal, or less than 4,000 lipase units/g fat ingested per day

Please see the full prescribing information and always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

What is Creon?

Creon is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Abbott Laboratories. Creon is prescribed to children and adults whose pancreases don’t make enough enzymes to digest food (exocrine pancreatic insufficiency).

It’s a pancreatic enzyme supplement that contains a mix of amylase, lipase, and protease digestive enzymes derived from pig pancreases. You take Creon as you eat or just after you’ve eaten a meal. The granules inside the capsule release the digestive enzymes into your stomach, where they help you digest the food you’ve just eaten.

Creon dosage

Creon is available in delayed-release capsule dosage form, in the following doses:

  • 6,000 USP units of lipase, 19,000 USP units of protease, and 30,000 USP units of amylase
  • 12,000 USP units of lipase, 38,000 USP units of protease, and 60,000 USP units of amylase
  • 24,000 USP units of lipase, 76,000 USP units of protease, and 120,000 USP units of amylase

CREON is not interchangeable with any other pancrelipase product.

  • Infants (up to 12 months) – before each feeding, give 2,000 to 4,000 lipase units per 120 mL of formula or breastfeeding
  • Children older than 12 months and younger than 4 years – initiate with 1,000 lipase units/kg of body weight per meal to a maximum of 2,500 lipase units/kg of body weight per meal, or less than 4,000 lipase units/g fat ingested per day
  • Children 4 years and older and adults – initiate with 500 lipase units/kg of body weight per meal to a maximum of 2,500 lipase units/kg of body weight per meal, or less than 4,000 lipase units/g fat ingested per day
  • For adults with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatectomy – the dosage is based on clinical symptoms, the level of steatorrhea, and the fat content of the diet

Please see the full prescribing information and always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Common side effects of Zenpep and Creon

The most common side effects of Zenpep in clinical trials compared to placebo-controlled trials include:

  • Abdominal pain
  • Constipation
  • Flatulence
  • Headaches

More serious side effects of Zenpep include:

  • Deterioration of the symptoms of gout (swollen and painful joints)
  • Allergic reactions
  • Fibrosing colonopathy – a rare bowel disorder
  • Renal cyst

The most common side effects of Creon in clinical trials compared to placebo-controlled trials include:

  • Abdominal pain
  • Constipation
  • Flatulence (gas) and bloating
  • Frequent or abnormal bowel movements
  • Vomiting
  • Dizziness
  • Increases in blood sugar (hyperglycemia)
  • Decreases in blood sugar (hypoglycemia)

More serious side effects of Creon include

  • Severe allergic reactions to the medication
  • Fibrosing colonopathy that may require surgery
  • An increase in blood uric acid levels that can cause joint swelling and pain (gout)
  • Irritation of the inside of your mouth if you don’t swallow Creon properly
  • Renal cyst

These aren’t all the side effects Zenpep or Creon can cause. You can find more details in the patient leaflet that comes with your medication. If you have any concerns about side effects, talk to your physician or pharmacist.

Zenpep and Creon drug interactions

Zenpep can interact with other medications. These include:

  • Calcium carbonate
  • Ferrous fumarate, ferrous gluconate, ferrous sulfate
  • Folic acid
  • Multivitamin with iron, multivitamin with iron and fluoride, multivitamin with minerals, multivitamin, prenatal
  • Sodium bicarbonate

Creon can interact with other medications. These include:

  • Calcium carbonate
  • Ferrous fumarate, ferrous gluconate, ferrous sulfate
  • Folic acid
  • Multivitamin with iron, multivitamin with iron and fluoride, multivitamin with minerals, multivitamin, prenatal
  • Sodium bicarbonate

Zenpep and Creon can interact with other medications. This can change how Zenpep and Creon and other medications work and can make side effects more likely. Tell your prescribing physician about all your drugs, including vitamins and dietary supplements.

Zenpep and Creon contraindications

You should not use Zenpep if you:

  • Are allergic to pork or any pig products
  • Are allergic to any of the other ingredients in Zenpep

Talk to your doctor before using Zenpep if you:

  • Have kidney disease, gout, or high blood uric acid (hyperuricemia)
  • Have ever had a blockage in your intestines
  • Have problems swallowing tablets
  • Have ever had scarring or thickening of your bowel wall (fibrosing colonopathy)
  • Are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed

You should not use Creon if you:

  • Are allergic to pork or any pig products
  • Are allergic to any of the other ingredients in Creon

Talk to your doctor before using Creon if you:

  • Have or have ever had fibrosing colonopathy
  • Have or have ever had any intestinal blockages
  • Have kidney disease
  • Have gout
  • Have high blood uric acid (hyperuricemia)
  • Have problems swallowing capsules
  • Are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed

Other drugs for pancreatic enzyme replacement therapy

  • Pancreaze
  • Ultresa
  • Viokace
  • Pertzye

If you have any concerns about Zenpep or Creon side effects, talk to your physician, or pharmacist for medical advice. Also inform your healthcare provider about any medical conditions, supplements, and over-the-counter meds you are taking. You are also encouraged to report side effects to the FDA: visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.
NiceRx Logo

Your medication,
$49 per month

Get your medication for only $49 per month through NiceRx.

Get Started