Angeliq Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Angeliq cost savings if eligible

If you are eligible for the Angeliq patient assistance program you can receive your medication for free. Our monthly service fee of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Angeliq through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Angeliq patient assistance program?

You could receive your Angeliq without paying the full retail price if you meet the eligibility criteria for assistance. The eligibility requirements are set by the pharmaceutical companies that are providing assistance programs. At NiceRx, we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Angeliq patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Angeliq.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Angeliq patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Angeliq medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx an Angeliq coupons provider?

At NiceRx, we help eligible individuals access the Angeliq patient assistance program. This means that we are not an Angeliq coupon, an Angeliq discount card, or an Angeliq copay card provider. We do not offer any medication trial offers, or free Angeliq samples.

Can NiceRx help me get Angeliq if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Angeliq medication, or you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much does Angeliq cost without insurance?

Angeliq costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Angeliq oral tablets (0.25 mg-0.5 mg) will typically cost around $590 for 84. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

How much does Angeliq cost with insurance?

The copay of Angeliq will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

What is Angeliq?

Angeliq is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Bayer.

Angeliq 0.25 mg drospirenone (DRSP)/0.5 mg estradiol (E2) is an estrogen/progestin indicated in women with an intact uterus for the treatment of:

  • Vasomotor symptoms (menopause symptoms) due to menopause

Angeliq 0.5 mg DRSP/1 mg E2 is an estrogen/progestin indicated in women with an intact uterus for the treatment of:

  • Vasomotor symptoms due to menopause
  • Vulvar and vaginal atrophy symptoms due to menopause

Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia. The Women’s Health Initiative (WHI) estrogen plus progestin substudy reported increased risks of stroke, deep vein thrombosis (DVT), pulmonary embolism (PE), myocardial infarction, and invasive breast cancer. The WHI Memory Study (WHIMS) estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older.

There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia. The WHI estrogen-alone substudy reported increased risks of stroke and DVT. The WHIMS estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older.

What doses of Angeliq are available?

Angeliq is available in tablet form, in the following doses: one tablet contains 0.25 mg drospirenone and 0.5 mg estradiol, one tablet contains 0.5 mg drospirenone and 1 mg estradiol.

Angeliq 0.25 mg DRSP/0.5 mg E2 – one tablet taken by mouth once daily.

Angeliq 0.5 mg DRSP/1 mg E2 – one tablet taken by mouth once daily.

Always speak with a healthcare professional for medical advice or about any changes to your dose so they can monitor and evaluate your condition.

Angeliq active ingredients

Angeliq contains the active ingredients estradiol and drospirenone.

Angeliq side effects

The most common side effects of Angeliq in clinical trials include:

  • Gastrointestinal and abdominal pain
  • Female genital tract bleeding
  • Breast pain and discomfort
  • Headache, mood changes
  • Vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding
  • Nausea, diarrhea
  • Fluid retention (swelling, rapid weight gain)

In rare instances, Angeliq can cause more serious side effects. These can include:

  • Gallbladder disease
  • Severe hypercalcemia – loss of vision, severe hypertriglyceridemia or cholestatic jaundice
  • Breast cancer
  • Risk of blood clots – heart attack, stroke, pulmonary embolism (life-threatening blood clot in the lungs), sudden vision loss, stabbing chest pain, shortness of breath, coughing up blood, pain or warmth in one or both legs, severe headaches
  • Exacerbation of endometriosis
  • Jaundice (yellowing of the skin or eyes)
  • Unusual vaginal bleeding
  • High blood sugar – increased thirst, increased urination, dry mouth, fruity breath odor

Your doctor will assess the benefits of using Angeliq against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Angeliq to the FDA. Visit, or call 1-800-FDA-1088.

Angeliq drug interactions

Angeliq can interact with other medications. These include:

  • Inducers and inhibitors of CYP3A4 – St. John’s wort (Hypericum perforatum), phenobarbital, carbamazepine, rifampin
  • Medications that can increase potassium, such as NSAIDs, potassium-sparing diuretics, potassium supplements, ACE inhibitors, angiotensin-II receptor antagonists, heparin
  • Women on thyroid replacement therapy

This list is not exhaustive and other prescription drugs may interact with Angeliq. Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Angeliq contraindications

You should not use Angeliq if you:

  • Are allergic to the active ingredient drospirenone/estradiol
  • Have had an allergic reaction to any of the other ingredients in Angeliq
  • Are pregnant or are planning to become pregnant
  • Have undiagnosed abnormal genital bleeding
  • Have a suspected, or history of cancer of the breast
  • Have a suspected estrogen-dependent neoplasia
  • Have an active DVT, PE, or a history of these conditions
  • Have an active arterial thromboembolic disease or a history of these conditions
  • Have renal impairment, hepatic impairment, or disease
  • Have adrenal insufficiency
  • Have protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders
  • Have had an anaphylactic reaction, angioedema, or hypersensitivity to Angeliq

Talk to your doctor about all your medical conditions before using Angeliq if you:

  • Are taking any of the medications that could interact with Angeliq
  • Are breastfeeding or are planning to breastfeed – estrogen administration to nursing women has been shown to decrease the quantity and quality of breast milk
  • Have vaginal bleeding of unknown cause
  • Have breast, ovary, or uterus cancer
  • Have blood clotting disorders
  • Have a current/history of blood clots, stroke, liver disease, kidney disease, adrenal gland problems, family medical history (including blood clots, breast lumps/cancer)
  • Have a family or personal history of angioedema, asthma, diabetes, seizures, migraine headaches, heart disease (e.g., high blood pressure, congestive heart failure, heart attack)
  • Have an underactive thyroid
  • Have hyperparathyroidism
  • Have high or low calcium blood level, high potassium blood level, low sodium blood level
  • Have mental/mood disorders
  • Have high blood pressure during pregnancy
  • Have yellowing eyes/skin (cholestatic jaundice) during pregnancy or with past estrogen use
  • Have uterus problems such as uterine fibroids, endometriosis
  • Have high blood cholesterol/fat (triglyceride) levels
  • Have gallbladder disease
  • Have obesity
  • Have porphyria or lupus

Angeliq generic

Angeliq is the trademark brand name for drospirenone/estradiol manufactured by Bayer. A generic version of drospirenone/estradiol is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Angeliq savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.