Besremi Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Besremi cost savings if eligible

With our assistance, you could access the Besremi patient assistance program and obtain your medication for free. We only charge a flat monthly fee of $49 per medication for our services.

Am I eligible for Besremi patient assistance?

We review each Besremi enrollment application individually to determine if you are eligible. Each assistance program has its own eligibility criteria and the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Besremi patient assistance program?

Our process makes it as easy as possible to apply for the Besremi patient assistance program. Begin by completing the enrollment application form on our website. Tell us about any medications that you are taking, including Besremi, your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers who will supply the medication, so it is important to make sure this information is accurate and up to date.

We will review the information that you have provided to determine whether you are eligible for patient assistance. If we can pre-qualify you for assistance, NiceRx will handle the full enrollment process on your behalf. If you are approved by the pharmaceutical company, you will typically start receiving your medication in 6 – 8 weeks.

Is NiceRx a Besremi coupons provider?

NiceRx is not a Besremi coupon, Besremi discount card, or Besremi copay card provider. We do not offer Besremi manufacturer coupons, Besremi discounts, rebates, Besremi savings cards, trial offers, or free Besremi samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Can NiceRx help me if I have insurance?

NiceRx may be able to help you if:

  • You have a high copay or coinsurance responsibility for Besremi
  • Your insurance company will not pay for your Besremi prescription
  • Your healthcare plan does not cover your medication
  • You do not have insurance

Please apply online to find out if we can help you.

How much does Besremi cost without insurance?

Without insurance, Besremi costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Besremi 500 mcg/mL solution will cost around $7,200 for 1 prefilled pen.

How much does Besremi cost with insurance?

The copay for Besremi will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is Besremi?

Besremi is an FDA (U.S. Food and Drug Administration) approved medication manufactured by PharmaEssentia Corporation. FDA approval is based on the results of the Peginvera study, a prospective, multicenter, single-arm trial of 7.5 years duration.

Besremi is an interferon alfa-2b used for the treatment of adults with polycythemia vera. Polycythemia vera is a blood disease that results from the overproduction of red blood cells due to genetic mutations involving the Janus Kinase 2 (JAK2) gene. Patients with polycythemia vera have blood that is thicker than normal, potentially resulting in increased risks for thrombosis and reduction in blood flow.

Risk of serious disorders – Interferon alfa products may cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders. Patients should be monitored closely and therapy withdrawn with persistently severe or worsening signs or symptoms of the above disorders.

What doses of Besremi are available?

Besremi is available in injection form, in the following doses: 500 mcg/mL solution in a single-dose prefilled syringe.

The recommended starting dose is 100 mcg by subcutaneous injection every 2 weeks (50 mcg if receiving hydroxyurea). Increase the dose by 50 mcg every 2 weeks (up to a maximum of 500 mcg) until stabilized.

See the full prescribing information for a complete boxed warning and always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Besremi active ingredients

The active ingredient of Besremi is ropeginterferon alfa-2b-njft, a monopegylated, long-acting interferon.

Besremi is thought to work by attaching to specific receptors in the body, setting off a chain reaction that makes the bone marrow reduce blood cell production.

The effectiveness and safety of Besremi were evaluated in a multicenter, single-arm trial that lasted 7.5 years. Besremi’s effectiveness was assessed by looking at how many patients achieved a complete hematological response. This meant that patients had a red blood cell volume of less than 45% without a recent phlebotomy, normal white cell counts and platelet counts, a normal spleen size, and no blood clots. Overall, 61% of patients had a complete hematological response.

Besremi side effects

The most common side effects of Besremi in clinical trials include:

  • Influenza-like illness
  • Arthralgia, musculoskeletal pain, fatigue
  • Pruritus
  • Nasopharyngitis
  • Low levels of white blood cells and platelets

In rare instances, Besremi can cause more serious side effects. These can include:

  • Depression and suicide
  • Cardiovascular toxicity
  • Decreased peripheral blood counts
  • Hypersensitivity reactions
  • Pancreatitis
  • Colitis
  • Pulmonary toxicity
  • Ophthalmologic toxicity
  • Hyperlipidemia
  • Hepatotoxicity – monitor liver enzymes and hepatic function at baseline and during treatment
  • Renal toxicity
  • Dental and periodontal toxicity
  • Dermatologic toxicity
  • Driving and operating machinery – avoid driving or using machinery if you experience dizziness, somnolence, or hallucination
  • Urinary tract infections

Your doctor will assess the benefits of using Besremi against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Besremi to the FDA. Visit, or call 1-800-FDA-1088.

Besremi drug interactions

Besremi can interact with other medications. These include:

  • CYP450 substrates
  • Myelosuppressive agents
  • Narcotics, hypnotics, or sedatives

This list is not exhaustive and other prescription drugs may interact with Besremi.

Besremi contraindications

You should not use Besremi if you:

  • Are allergic to the active ingredient ropeginterferon alfa-2b-njft
  • Are allergic to any of the other ingredients in Besremi

Talk to your doctor before using Besremi if you:

  • Are taking any of the medications that could interact with Besremi
  • Have a history of severe psychiatric disorders
  • Have hypersensitivity to interferon
  • Have hepatic impairment
  • Have a history or presence of active serious or untreated autoimmune disease
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Besremi generic

Besremi is the trademark brand name for ropeginterferon alfa-2b njft manufactured by PharmaEssentia Corporation. A generic version of ropeginterferon alfa-2b njft is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Besremi savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.