Dexilant Dosage, forms & strengths
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Dexilant (dexlansoprazole) is a prescription proton pump inhibitor (PPI) that is manufactured by Takeda Pharmaceuticals. Dexilant works by decreasing the amount of acid produced in your stomach. It is approved by the FDA for use in adults and children 12 years of age and older:
- Healing of erosive esophagitis (inflammation and ulceration of the esophagus)
- Maintaining healing of erosive esophagitis and relief of heartburn
- Treating heartburn that is associated with symptomatic non-erosive gastroesophageal reflux disease (GERD)
Dexilant forms and strengths
Dexilant is available as a delayed-release capsule in the following strengths:
- 30 mg capsule
- 60 mg capsule
Dexilant dosage for adults
The recommended starting dose of Dexilant is 30mg or 60mg once daily, depending on the condition being treated. Dexilant can be taken with or without food.
Dexilant adult dosage chart
|Indication||Starting dosage||Standard dosage||Maximum dosage
|Healing of erosive esophagitis (EE)||60mg once daily.||60mg once daily for up to 8 weeks.||60mg once daily for up to 8 weeks.
|Maintenance of healed EE and heartburn relief||30mg once daily.||30mg once daily.||30mg once daily for up to 6 months.
|Symptomatic non-erosive GERD||30mg once daily.||30mg once daily.||30mg once daily for 4 weeks.
Dexilant pediatric dosage chart
|Indication||Age||Starting dosage||Standard dosage||Maximum dosage
|Healing of erosive esophagitis (EE)||12 years and older||60mg once daily.||60mg once daily for up to 8 weeks.||60mg once daily for up to 8 weeks.
|Maintenance of healed EE and heartburn relief||12 years and older||30mg once daily.||30mg once daily for up to 6 months.||30mg once daily for up to 6 months.
|Symptomatic non-erosive GERD||12 years and older||30mg once daily.||30mg once daily for 4 weeks.||30mg once daily for 4 weeks.
Dexilant dosage restrictions
- Mild hepatic impairment (Child-Pugh A): Dose adjustment is not necessary
- Moderate hepatic impairment (Child-Pugh B): Not to exceed 30 mg/day
- Severe hepatic impairment (Child-Pugh C): Not recommended
- No dosage adjustment of Dexilant is necessary for patients with renal impairment
How to take Dexilant
- Take Dexilant exactly as prescribed by your doctor. Do not change your dose or stop taking this medication without talking to your doctor first.
- Dexilant may be taken with or without food.
- Swallow Dexilant capsules whole. If you have trouble swallowing, you can open the Dexilant capsule and sprinkle its contents on a tablespoon of applesauce. The applesauce mixture should not be chewed and must be swallowed immediately.
- If you miss a dose of Dexilant, take it immediately. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not an extra dose to make up for the missed dose.
- If you take too much Dexilant, call your healthcare provider right away or go to the nearest emergency room.
- Dexliant is a pregnancy category B as there are no adequate and well-controlled studies with dexlansoprazole in pregnant women. Discuss the risks of taking Dexilant while pregnant with your healthcare provider.
- It is not known whether Dexilant is excreted in breast milk. It was found in rat milk during animal studies. Discuss with your healthcare provider if you should remain on Dexilant while breastfeeding.
- Read the Instructions for Use and Medication Guide with drug information that comes with your Dexilant prescription.
- Store Dexilant at room temperature between 68°F to 77°F (20°C to 25°C).
Dexilant dosage FAQs
What are some side effects of Dexilant?
Some common adverse effects of Dexilant can include:
- Stomach pain
- Upper respiratory tract infections
Some serious side effects of Dexilant include:
- Severe diarrhea that may be due to Clostridium difficile
- Bone fracture
- Low magnesium levels (hypomagnesemia)
- Low vitamin B12 levels
- Increased risk or worsening of lupus erythematosus
- Serious allergic reactions (rash, face and throat swelling, difficulty breathing)
Call your healthcare provider for medical advice about side effects. You can report any adverse reactions you experience to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
What are some drug interactions with Dexilant?
When Dexilant is taken with other medicines, they may interact and change how they work. It may also increase the severity of certain side effects or make them more likely to occur. Make sure your healthcare professional is aware of all the medicines you take, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Some major drug interactions with Dexilant include:
- Drugs that are dependent on stomach acid for absorption such as digoxin, itraconazole, ketoconazole, erlotinib, and mycophenolate mofetil.
- St. John’s wort
- Antiretroviral drugs such as rilpivirine, atazanavir, saquinavir, and nelfinavir
Are there any contraindications or precautions with Dexilant?
You should not take Dexilant if you:
- Have a known hypersensitivity to Dexilant or any of its inactive ingredients
How long does Dexilant stay in the system?
Dexilant binds strongly to parietal cells in your stomach lining, so it stays in your circulation for up to 24 hours.
What is the maximum dosage for Dexilant?
The maximum dose of Dexilant is 60mg once daily, with or without food.
Is it safe to use Dexilant while pregnant or breastfeeding?
Dexilant is a pregnancy category B, meaning there are no adequate and well-controlled studies on pregnant women. There were no adverse effects on the fetus in reproduction studies in rabbits. Dexilant should only be used during pregnancy if it is absolutely needed.
The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.