Jardiance Dosage, forms & strengths
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Jardiance (empagliflozin) is a prescription sodium-glucose co-transporter 2, or SGLT2 inhibitor that is manufactured by Boehringer Ingelheim Pharmaceuticals. It is U.S. Food and Drug Administration (FDA)-approved:
- To reduce the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure.
- To reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and established cardiovascular disease.
- As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Jardiance is not approved to treat type 1 diabetes or diabetic ketoacidosis.
Jardiance forms and strengths
Jardiance is available as a film-coated tablet in the following strengths:
- 10 mg tablet
- 25 mg tablet
Jardiance dosage for adults
The recommended dose of Jardiance is 10 mg once daily in the morning. It can be taken with or without food. The dose can be increased to 25mg if you need additional glycemic control. Jardiance can be used at these doses for monotherapy or as combination therapy with other oral agents or insulin.
Jardiance adult dosage chart
|Indication||Starting dosage||Standard dosage||Maximum dosage|
|Type 2 diabetes||10mg once daily in the morning, with or without food.||10mg once daily in the morning, with or without food.||25mg once daily in the morning, with or without food.|
|Reduction of CV death||10mg once daily in the morning, with or without food.||10mg once daily in the morning, with or without food.||25mg once daily in the morning, with or without food.|
The safety and effectiveness of Jardiance have not been established in pediatric patients under 18 years of age.
Jardiance dosage restrictions
- Jardiance is not recommended in patients without established heart disease or cardiovascular risk factors that have renal impairment or kidney disease with an eGFR less than 30 mL/min/1.73 m^2.
- There is no dose adjustment necessary in patients with hepatic impairment.
How to take Jardiance
- Read the Instructions for Use and Medication Guide, including the Boxed Warning that comes with your Jardiance prescription.
- Take Jardiance exactly as your healthcare provider prescribes it.
- Jardiance should be taken once daily in the morning, with or without food.
- If you miss a dose of Jardiance, take the missed dose as soon as you remember. If you do not remember until it is time for your next dose, skip the missed dose and go back to your regular dosage schedule. Do not take an extra dose of Jardiance to make up for the missed dose.
- If you take too much Jardiance, call your healthcare provider or go to the nearest hospital emergency room immediately.
- Your healthcare provider may do blood tests to check your kidney function before and during your treatment with Jardiance.
- Store Jardiance at room temperature between 68°F to 77°F (20°C to 25°C) away from light and moisture.
- Always keep Jardiance and all medicines out of the reach of children.
- Notify your doctor if you are pregnant, plan on becoming pregnant, or are breastfeeding.
Jardiance dosage FAQs
What are some side effects of Jardiance?
Some common adverse reactions to Jardiance include:
- Urinary tract infections
- Female genital mycotic infections (yeast infection)
- Upper respiratory tract infection
- Increased urination
- Joint pain
- Excessive thirst
- Weight loss
Some serious side effects of Jardiance include:
- Increased risk of metabolic acidosis and ketoacidosis (increased ketones in your blood or urine)
- Volume depletion, especially if taken with loop diuretics
- Urosepsis and pyelonephritis
- Serious, life-threatening genital infection (Fournier’s Gangrene)
- Hypoglycemia (low blood sugar levels) when used in combination with insulin secretagogues or insulin
- Severe hypersensitivity or allergic reactions
You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.
What are some of the drug interactions with Jardiance?
You are at an increased risk of hypoglycemia if you use Jardiance along with insulin secretagogues (sulfonylureas) or insulin.
Taking Jardiance with diuretics can increase your urine volume and frequency of urination, which can increase your risk of volume depletion or hypotension (low blood pressure).
Jardiance can also interfere with certain glycemic control assays used to monitor your blood sugar levels.
Be sure to tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Are there any contraindications or precautions with Jardiance?
You should not take Jardiance if you:
- Have had a serious allergic reaction to Jardiance or any of its inactive ingredients.
- Are on dialysis.
How long does Jardiance stay in the system?
Based on its estimated half-life of 12.5 hours, Jardiance will remain in your bloodstream for approximately 2.5 days after your last dose.
What is the maximum dosage for Jardiance?
The maximum dose of Jardiance is 25mg once daily in the morning, with or without food.
Is it safe to use Jardiance while pregnant or breastfeeding?
Based on animal data showing adverse kidney effects, Jardiance is not recommended during the second and third trimesters of pregnancy. Jardiance is also not recommended for use during lactation.
Will lab monitoring be done when taking Eliquis?
While taking Jardiance, you should regularly monitor your blood glucose levels. You should be able to recognize the signs and symptoms of hypoglycemia (sweating, increased heart rate, shakiness, dizziness). Your doctor may monitor your glycemic control with a hemoglobin A1c (HbA1c) test every 3 to 6 months. In addition to this, your doctor may also monitor your renal function, blood pressure, and cholesterol level.