Myrbetriq Dosage, forms & strengths
Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Myrbetriq medication.
Get started today
Myrbetriq (mirabegron) is a beta-3 receptor adrenergic agonist that is manufactured by Astellas Pharma US, Inc. It is indicated by the U.S. Food and Drug Administration (FDA) to treat:
- Overactive bladder (OAB) in adults with symptoms such as urinary incontinence, urgency, and urinary frequency. Myrbetriq can be used as monotherapy or along with the antimuscarinic medication Vesicare (solifenacin succinate).
- Neurogenic detrusor overactivity (NDO) in pediatric patients 3 years of age and older that have a body weight of at least 35kg (77 lbs).
How does Myrbetriq work?
The detrusor muscle in your bladder wall relaxes to let your bladder fill with urine and then contracts to squeeze the bladder and release the urine. With an overactive bladder, the bladder muscle contracts more frequently or uncontrollably. This decreases the amount of urine your bladder can hold and makes you feel like you need to urinate frequently. It can also cause urine leakage (incontinence).
Myrbetriq works by binding to beta-3 receptors on detrusor muscle cells. This causes the muscle to relax and allows more urine to be stored by the bladder. This helps decrease how often you urinate as well as prevents incontinence.
Myrbetriq dosage forms and strengths
Myrbetriq is available as an oral tablet in the following strengths:
- 25mg extended-release tablet
- 50mg extended-release tablet
Myrbetriq is available as an extended-release tablet or oral granules. Myrbetriq tablets and Myrbetriq granules are not interchangeable and cannot be substituted on a milligram-per-milligram basis. Your dose may be adjusted if you have severe kidney or liver impairment.
Myrbetriq adult dosage chart
Overactive bladder (OAB)
25mg by mouth once daily, either alone or along with Vesicare (solifenacin) 5mg once daily.
25mg to 50mg by mouth once daily.
50mg per day
Myrbetriq pediatric dosage chart
Neurogenic detrusor overactivity (NDO)
3 years and older weighing 35kg or more
25mg by mouth once daily.
25mg to 50mg by mouth once daily.
50mg per day
Myrbetriq dosage restrictions
- No dose adjustment is needed for patients with mild or moderate renal impairment.
- In adult patients with severe renal impairment (eGFR 15-29ml/min/1.73 m^2 ), the daily dose of Myrbetriq should not exceed 25mg.
- Myrbetriq is not recommended for end-stage renal disease (ESRD) patients or those on dialysis.
- No dose adjustment is needed for patients with mild hepatic impairment (Child-Pugh Class A).
- In adult patients with moderate hepatic impairment (Child-Pugh Class B), the daily dose of Myrbetriq should not exceed 25mg.
How to take Myrbetriq
- Read the Full Prescribing Information including the Black Boxed Warning, Patient Information leaflet, and Medication Guide that comes with Myrbetriq.
- Take Myrbetriq exactly as your doctor prescribes it to you. Do not change your dose or stop taking Myrbetriq without discussing it with them.
- Myrbetriq tablets are usually taken once a day. If you are taking Vesicare (solifenacin) with Myrbetriq, you should take them once a day at the same time.
- You should swallow Myrbetriq tablets whole with water. You should not break, crush, or chew the tablet. Adult patients can take Myrbetriq with or without food. Pediatric patients should take Myrbetriq with food.
- If you miss a dose of Myrbetriq, take it immediately. If it has been more than 12 hours since taking your last dose of Myrbetriq, skip the missed dose and take the next dose at its regular time.
- Store Myrbetriq tablets in the original bottle at room temperature between 15°C-30°C (59°F-86°F).
Myrbetriq dosage FAQs
What are some common side effects of Myrbetriq?
The most common adverse reactions of Myrbetriq include:
- Hypertension (high blood pressure)
- Nasopharyngitis (common cold)
- Urinary tract infection (UTI)
- Dry mouth
- Tachycardia (fast heart rate)
- Back pain
Myrbetriq can cause serious side effects including:
- Hypersensitivity reactions including hives, angioedema, and trouble breathing
- Increased risk of urinary retention if you have a bladder outlet obstruction
- Atrial fibrillation (AFib)
Contact your healthcare professional for medical advice about any side effects you experience while taking Myrbetriq. You can report your side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
What are some drug interactions with Myrbetriq?
When Myrbetriq is taken with other drugs, it may change the way they work or increase the frequency and severity of side effects. Make sure your doctor is aware of all prescription drugs, over-the-counter medications, vitamins, and herbal supplements you take. Some major drug interactions with Myrbetriq include:
- Myrbetriq is a moderate CYP2D6 inhibitor, so it can increase the concentrations of CYP2D6 substrates including Rythmol (propafenone), Mellaril (thioridazine), Tambocor (flecainide), Norpramin (desipramine), and Lopressor (metoprolol)
- Lanoxin (digoxin)
- Coumadin (warfarin)
Are there any contraindications or precautions with Myrbetriq?
Myrbetriq should be used with caution in patients who have any of the following medical conditions:
- Myrbetriq can increase your blood pressure. If you have hypertension, you should periodically monitor your blood pressure. It is not recommended if you have uncontrolled high blood pressure.
- Increased risk of urinary retention if you have a bladder outlet obstruction or are taking an anticholinergic medication such as Vesicare (solifenacin).
- Allergic reaction to Myrbetriq or any of its excipients.
- Your dose of Myrbetriq may be adjusted if you have serious liver problems or kidney problems.
How long does it take for Myrbetriq to start working?
You should notice an improvement in your urinary symptoms within the first week but it may take 1 to 2 months before you see the full benefits of Myrbetriq.
Can I drink alcohol while taking Myrbetriq?
Myrbetriq is not known to interact with alcohol. However, alcohol consumption can cause some of the same side effects as Myrbetriq, including headache and dizziness. It can also irritate your bladder and increase urination.
How do I store Myrbetriq?
Store Myrbetriq tablets in the original bottle at room temperature between 15°C-30°C (59°F-86°F). Always keep Myrbetriq and all other medications out of the reach of children.
Is it safe to use Myrbetriq while pregnant or breastfeeding?
There is no clinical data on the use of Myrbetriq in pregnant women to know if there is a risk for birth defects or miscarriage. There is also no data on whether Myrbetriq is found in breast milk or the effects it may have on the infant if used during lactation. It was found in rat milk during animal studies. You should always discuss the risks and benefits of any medication with your healthcare provider if you are pregnant, plan on becoming pregnant, or are breastfeeding.
Is there a generic for Myrbetriq?
Currently, there is no generic for Myrbetriq available on the market. However, you can still save on brand-name drugs like Myrbetriq through NiceRx if eligible.
Related resources for Myrbetriq
Myrbetriq research & news
The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.