Piqray Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Piqray cost savings if eligible

With our assistance, you could access the Piqray patient assistance program and obtain your medication for free. We only charge a flat monthly fee of $49 per medication for our services.

Am I eligible for Piqray patient assistance?

We review each Piqray enrollment application individually to determine if you are eligible. Each assistance program has its own eligibility criteria and the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Piqray patient assistance program?

Our process makes it as easy as possible to apply for the Piqray patient assistance program. Begin by completing the enrollment application form on our website. Tell us about any medications that you are taking, including Piqray, your healthcare provider, your insurance plan, and your household income. This information is required by the pharmaceutical manufacturers who will supply the medication, so it is important to make sure this information is accurate and up to date.

We will review the information that you have provided to determine whether you are eligible for patient assistance. If we can pre-qualify you for assistance, NiceRx will handle the full enrollment process on your behalf. If you are approved by the pharmaceutical company, you will typically start receiving your medication in 6 – 8 weeks.

Is NiceRx a Piqray coupons provider?

NiceRx is not a Piqray coupon, Piqray discount card, or Piqray copay card provider. We do not offer Piqray manufacturer coupons, Piqray discounts, rebates, Piqray savings cards, trial offers, or free Piqray samples. We are a service provider that helps eligible individuals access their medication directly from the U.S. pharmaceutical company.

Can NiceRx help me if I have insurance?

NiceRx may be able to help you if:

  • You have a high copay or coinsurance responsibility for Piqray
  • Your insurance company will not pay for your Piqray prescription
  • Your healthcare plan does not cover your medication
  • You do not have insurance

Please apply online to find out if we can help you.

How much does Piqray cost without insurance?

Without insurance, Piqray costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Piqray  oral tablet (200 mg-50 mg) will cost around $18,300 for 56 tablets.

How much does Piqray cost with insurance?

The copay for Piqray will depend on the terms of your healthcare plan. Your healthcare provider or pharmacist will be able to calculate your copay with your current insurance. Contact them to find out more.

What is Piqray?

Piqray is an FDA-approved medication manufactured by Novartis. It contains the prescription drug alpelisib that is classed as a kinase inhibitor and is used in combination with fulvestrant to treat postmenopausal women and men, with hormone receptor (HR)- positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA mutation, advanced breast cancer or metastatic breast cancer. FDA approval is based on the results of the Phase III trial, SOLAR-1.

What doses of Piqray are available?

Piqray is available in tablet form, in the following doses: 50 mg, 150 mg, 200 mg

The adult dose for breast cancer is 300 mg once a day with food until disease progression or unacceptable toxicity occurs. The recommended dose of fulvestrant is 500 mg orally on days 1, 15, and 29, and once monthly thereafter when given with Piqray.

Take Piqray tablets with food, at the same time each day. Swallow the tablet whole. Do not crush, chew, or break it. If you vomit shortly after taking Piqray, do not take another dose. Wait until your next dose is due to take the medicine again.

Store at room temperature away from moisture and heat. Keep each tablet in the blister pack until you are ready to take one.

Take Piqray as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition. Your blood sugar levels will be checked frequently. You may need other blood tests.

Piqray active ingredients

Alpelisib is an inhibitor of phosphatidylinositol-3-kinase (PI3K) with inhibitory activity mainly against PI3Kα.

In breast cancer cell lines, alpelisib inhibits the phosphorylation of PI3K downstream targets. This includes Akt and showed activity in cell lines having a PIK3CA mutation. In studies, alpelisib inhibited the PI3K/Akt signaling pathway and reduced the growth of the tumor in xenograft models, including models of breast cancer.

PI3K inhibition by alpelisib treatment has been shown to cause an increase in estrogen receptors (ER) in breast cancer cells. The combination of alpelisib and fulvestrant showed increased antitumor activity, compared to using either treatment on its own.

Piqray side effects

The most common side effects of Piqray in clinical trials include:

  • Nausea, vomiting
  • Loss of appetite, weight loss
  • Tiredness or feeling weak
  • Mouth sores
  • Rash
  • Alopecia (hair loss)
  • Abnormal blood tests

In rare instances, Piqray can cause more serious side effects. These can include:

  • Severe skin reactions including Stevens-Johnson syndrome (skin disorders that may begin with flu-like symptoms followed by a painful rash that blisters)
  • Pneumonitis – chest pain, cough, feeling short of breath
  • Severe diarrhea – can lead to dehydration and kidney problems
  • Blisters or ulcers in your mouth, red or swollen gums, problems swallowing
  • High blood sugar (hyperglycemia) – increased thirst and/or urination, dry mouth, fruity breath, confusion, hunger, weight loss – your health care provider may monitor your blood sugar levels more often if you have a history of type 2 diabetes

Your doctor will assess the benefits of using Piqray against your risk of side effects.

Patients are encouraged to report negative side effects or adverse reactions of Piqray to the FDA. Visit, or call 1-800-FDA-1088.

Piqray drug interactions

Piqray can interact with other medications. These include:

  • CYP3A4 Inducers – carbamazepine, rifampin
  • BCRP Inhibitors closely monitor for increased adverse reactions
  • CYP2C9 Substrates – decreases in the plasma concentration of these drugs may reduce activity

This list is not exhaustive and other drugs may interact with Piqray. Tell your health care professional about all of the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements.

Piqray contraindications

You should not use Piqray if you:

  • Are have had a severe allergic reaction to the active ingredient alpelisib
  • Are allergic or have hypersensitivity to any of the other ingredients in Piqray

Talk to your doctor before using Piqray if you:

  • Are taking any of the medications that could interact with Piqray
  • Are pregnant or are planning to become pregnant – Alpelisib and fulvestrant both can harm an unborn baby. If you are a woman using birth control to prevent pregnancy while you are using this medicine and for at least 1 week after your last dose. You may need to have a negative test before starting treatment
  • Are breastfeeding or are planning to breastfeed – do not breastfeed while using Piqray, and for at least 1 week after your last dose. You may not be able to breastfeed for 1 year after your last dose of fulvestrant
  • Have diabetes
  • Have had a severe skin rash
  • Women who also take fulvestrant may need to prevent pregnancy for at least 1 year after treatment

Piqray generic

Piqray is the trademark brand name for alpelisib manufactured by Novartis. A generic version of alpelisib is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Piqray savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.