Latuda side effects and how to avoid them

Latuda is the brand name of an FDA-approved drug to treat mental illness. Latuda can cause adverse reactions. The most common side effects tend to be drowsiness and trouble sleeping, to serious movement disorders and worsening mental health. Learn more about the most common Latuda side effects and how to avoid them.

What is Latuda?

Latuda is a medication that belongs to a group of drugs called antipsychotics. It is used for the treatment of bipolar disorder and schizophrenia in adults. It is a central nervous system depressant, which means it reduces activity in parts of the brain. This reduced activity helps to ease the symptoms of both conditions.

Schizophrenia is a mental disorder that causes episodes of psychosis. In these periods you may see or hear things that aren’t really there, have delusional thoughts, and become unusually suspicious. Other symptoms can include difficulties thinking, social withdrawal, and a lack of motivation. Schizophrenia is thought to be caused by a mixture of genetics and events in your life.

Bipolar disorder, previously called manic depression, is another mental disorder. It causes periods of both depression and elevated mood. During the episodes of elevated mood, you may experience psychosis too, as well as excess energy and impulsive behavior. Bipolar disorder is also thought to be caused by both genetics and life events.

Latuda is prescribed to treat:

  • Depressive episodes in adults and children 10 years of age and older with bipolar 1 disorder
  • Depressive episodes in adults with bipolar 1 disorder in combination with mood stabilizer medications like lithium or valproate
  • Schizophrenia in adults and children 13 years of age and older

How does Latuda work?

Latuda contains an active ingredient called lurasidone, a type of atypical antipsychotic drug. When you swallow a Latuda tablet, it breaks down in your digestive tract and the lurasidone it contains is absorbed into your blood. The lurasidone is then transported to your brain in your bloodstream.

Once the lurasidone crosses the blood-brain barrier, it attaches to areas on your brain cells called receptors. These receptors are used to send messages between your brain cells and help to regulate your brain function. Chemicals produced by your brain, called neurotransmitters fit into the receptors, stimulating them and making them send a certain form of signal to the surrounding brain cells. By blocking some of your receptors, lurasidone reduces some areas of brain activity.

Lurasidone blocks receptors that are stimulated by the neurotransmitters dopamine and serotonin. These neurotransmitters help regulate areas of brain activity involved with mood, reward feedback, pleasure, cognition, learning, and memory. By reducing the signals sent by dopamine and serotonin, it is thought that lurasidone helps to normalize brain activity. And this has been shown to lessen the symptoms of schizophrenia and bipolar depression.

Latuda withdrawal

If you stop taking Latuda suddenly, you can experience withdrawal symptoms from the medication, called Latuda discontinuation syndrome. This can cause unpleasant withdrawal-like side effects, including nausea, restlessness, and uncontrolled muscle movements. In some cases, Latuda withdrawal can be severe.

Talk to your doctor if you want to stop taking Latuda. They may decrease your dose slowly to avoid Latuda discontinuation syndrome.

Latuda common side effects

The most common side effects of Latuda include:

  • Sleepiness or drowsiness
  • A runny nose
  • Nausea
  • Vomiting
  • Restlessness and feeling like you need to move (akathisia)
  • Muscle stiffness can slow your movements and make it difficult to move
  • Tremors
  • Problems sleeping (insomnia)
  • Weight gain

Latuda serious side effects

These are rarer, but can include:

  • An increased risk of suicidal thoughts and suicide, particularly in children, adolescents, and young adults (Latuda is not approved for use in pediatric patients with depression – FDA black-box warning)
  • An increased risk of strokes and death in elderly patients who have dementia-related psychosis (Latuda is not approved to treat dementia-related psychosis in older adults – FDA black-box warning)
  • Severe allergic reactions to the medication
  • Worsening episodes of mania or hypomania (manic episodes) in people with bipolar disorder
  • Neuroleptic Malignant Syndrome (NMS) – is a rare but potentially fatal condition caused by a reaction to the medication
  • Uncontrolled body movements (tardive dyskinesia), often in your face and tongue (these movements may not go away after you stop taking Latuda)
  • High blood sugar
  • High blood fats (cholesterol and triglycerides)
  • Abnormally high prolactin levels called hyperprolactinemia
  • A fall in white blood cell counts
  • A fall in blood pressure (orthostatic hypotension)
  • Seizures (convulsions)
  • Trouble swallowing can cause food or liquid to get into your lungs
  • Problems controlling the body temperature that can lead to you overheating and getting dehydrated
  • An increased risk of falls as Latuda can cause dizziness and sleepiness

Your doctor will assess your risk of side effects versus the benefits of taking Latuda. These aren’t all the side effects that Latuda can cause. To find out more, you can read more about Latuda side effects in the leaflet that comes with your medication. Talk to your doctor if you’re concerned about any side effects.

Latuda drug interactions

Latuda should not be taken with medicines called CYP3A4 inhibitors or CYP3A4 inducers, including:

  • Itraconazole, ketoconazole, or voriconazole, taken to treat fungal infections
  • Clarithromycin or rifampin, antibiotics taken to treat a range of bacterial infections
  • Ritonavir, taken to treat an HIV-1 infection
  • Avasimibe, taken to treat high cholesterol
  • Carbamazepine, phenobarbital, phenytoin, and rufinamide, taken for seizures
  • A herbal supplement called St John’s wort
  • Grapefruit juice

Talk to your doctor if you take the following medicines with Latuda:

  • Any other medications you’re taking to treat your bipolar disorder or schizophrenia
  • Any other medications that can affect your serotonin or dopamine levels such as antidepressants
  • Any antibiotics
  • Any medicines that lower your blood pressure

Latuda warnings & precautions

Don’t take Latuda if you:

  • Are allergic to the active ingredient lurasidone
  • Are allergic to any of the other ingredients found in Latuda (listed in the leaflet which comes with the medication)
  • Are under 18 years of age

Talk to your physician before taking Latuda if you:

  • Have diabetes
  • Have decreased kidney or liver function
  • Have heart disease or a family history of having an irregular heartbeat
  • Have a history of blood clots
  • Have a history of epilepsy or seizures
  • Have Parkinson’s disease or dementia
  • Often have suicidal thoughts or behaviors
  • Are pregnant or breastfeeding

How to avoid Latuda side effects

While completely avoiding Latuda side effects may not be possible, there are some things you can do to reduce their severity:

1. Stick to the recommended dosage

Take your prescribed dose that has been recommended by your healthcare professional. Stick to the same timing for taking your medication and taking it consistently will make a big difference in how well Latuda works for you. Food will help your body absorb Latuda more efficiently. Eat at least 350 calories before taking Latuda.
If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Refer to the medication guide for more drug information.

2. Keep cool

Your temperature may fluctuate when taking Latuda, to avoid this keep cool and stay hydrated. Keep a water bottle with you and refill it on a regular basis.

3. Avoid alcohol

Alcohol may worsen any side effects you may experience. Read our blog Latuda and alcohol: can they be used together? for more information.

4. Pay attention to your body

Paying attention to how your body feels when taking Latuda is important, taking particular attention to worsening symptoms or new symptoms. Talk to your doctor straight away for medical advice if you start to experience any side effects of Latuda when taking it.

5. Discuss medical history

Discussing your medical history with your prescribing healthcare provider is important to help them understand how well Latuda will work for you. Give a complete list of all the prescription drugs, including over-the-counter meds, supplements, and medical conditions you may have. Talking with your doctor will also allow them to pick up any drug interactions with Latuda that may increase possible side effects.

Medically reviewed

A medical professional has reviewed this article.

Jamie Winn, PharmD
Jamie Winn, PharmD

Jamie Winn, PharmD

Medical Writer & Reviewer

Jamie Winn, PharmD

Medical Writer & Reviewer

Dr. Jamie Winn received his Doctor of Pharmacy in 2002 from the University of South Carolina College of Pharmacy, Columbia, SC. Jamie is a medical reviewer for NiceRx.

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Sources (4)


  2. National Library of Medicine - Lurasidone HCl (Latuda), an Oral, Once-Daily Atypical Antipsychotic Agent for the Treatment of Patients with Schizophrenia

  3. DailyMed - Drug label information for Latuda

  4. National Library of Medicine - Lurasidone: A New Treatment Option for Bipolar Depression—A Review

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.