Anoro Ellipta Dosage, forms & strengths
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Anoro Ellipta (umeclidinium bromide/vilanterol) is the combination of a long-acting beta-agonist (LABA) and an anticholinergic medication that is manufactured by GlaxoSmithKline (GSK). It is FDA-approved to improve lung function in the maintenance treatment of adults with chronic obstructive pulmonary disease (COPD). Anoro Ellipta is not approved for use in pediatric patients under 18 years of age. It is also not indicated in the treatment of asthma or acute bronchospasms.
How does Anoro Ellipta work?
Anoro Ellipta (umeclidinium/vilanterol) is a long-acting muscarinic antagonist (umeclidinium) and a selective long-acting beta-2 adrenergic agonist (vilanterol). Umeclidinium attaches to the M1-M5 receptors in your lungs. Experts believe M3 receptor inhibition in the smooth muscle in your lungs causes bronchodilation. Vilanterol stimulates beta-2 receptors to relax the smooth muscle in your airways, which leads to bronchodilation.
Anoro Ellipta dosage forms and strengths
Anoro Ellipta contains 2 foil blister strips of inhalation powder. One strip contains umeclidinium bromide 62.5 mcg per blister and the other contains vilanterol trifenatate 25 mcg per blister.
Anoro Ellipta dosage
The recommended dose of Anoro Ellipta is one inhalation once a day, at the same time each day. It is indicated to treat COPD in adult patients. The safety and effectiveness of Anoro Ellipta have not been established in pediatric patients under the age of 18.
Anoro Ellipta dosage restrictions
- No dosage adjustment is necessary for patients with any degree of renal impairment.
- No dosage adjustment is necessary for patients with moderate hepatic impairment. There have not been any studies performed on patients with severe hepatic impairment.
How to take Anoro Ellipta
- Read the Full Prescribing Information, Instructions for Use, and Medication Guide that comes with your Anoro Ellipta.
- Your healthcare provider should show you the correct way to use your Anoro Ellipta inhaler before you take your first dose.
- Use Anoro Ellipta exactly as your healthcare provider prescribes it to you. Do not change your dose or stop taking Anoro Ellipta without discussing it with them.
- Use 1 inhalation of Anoro Ellipta once daily, at the same time every day.
- If you miss a dose of Anoro Ellipta, take it immediately. Do not take more than 1 inhalation of Anoro Ellipta per day.
- If you think you have taken too much Anoro Ellipta, call your doctor or go to the nearest emergency room if you have symptoms such as worsening shortness of breath, chest pain, irregular heartbeat, or rapid heart rate.
- Do not stop using Anoro Ellipta without discussing it with your doctor as your breathing symptoms may worsen if you suddenly stop this medication.
- Anoro Ellipta will not replace your short-acting rescue inhaler. You should always keep a rescue inhaler with you to treat sudden breathing problems.
Anoro Ellipta dosage FAQs
What are some common side effects of Anoro Ellipta?
The most common adverse reactions of Anoro Ellipta reported during clinical trials (incidence ≥1% and more common than placebo) include:
- Pharyngitis (sore throat)
- Lower respiratory tract infection
- Muscle spasms
- Neck pain
- Chest pain
- Dry mouth
Anoro Ellipta can sometimes cause serious adverse reactions including:
- Life-threatening allergic reactions including hives, and anaphylaxis
- Cardiovascular effects such as fast heart rate, palpitations, or high blood pressure
- Increased blood sugar
- Low potassium levels
- Narrow-angle glaucoma (eye pain or discomfort, blurred vision, seeing halos or colors around lights)
- Urinary retention
Contact your healthcare professional for medical advice about any adverse effects you experience while taking Anoro Ellipta. You can report your side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
What are some drug interactions with Anoro Ellipta?
When Anoro Ellipta is taken with other drugs, it may change how they work or increase the frequency and severity of side effects. Make sure your doctor is aware of all prescription drugs, over-the-counter medications, vitamins, and herbal supplements you take, including:
- Strong CYP3A4 inhibitors – ketoconazole, ritonavir, erythromycin
- Monoamine oxidase inhibitors (MAOIs) – tranylcypromine
- Tricyclic antidepressants – nortriptyline, amitriptyline
- Beta-blockers – propranolol, atenolol
- Diuretics – torsemide, bumetanide, furosemide
- Anticholinergics – glycopyrrolate, tiotropium
Are there any contraindications or precautions with Anoro Ellipta?
Anoro Ellipta is contraindicated in patients who have a severe hypersensitivity reaction to milk proteins (lactose), magnesium stearate, or any other ingredients in the formulation. Asthma patients should not take Anoro Ellipta without taking an inhaled corticosteroid along with it.
Some other precautions that should be monitored and treated if indicated include:
- Do not use Anoro Ellipta with other long-acting beta-agonists or sympathomimetic drugs as they may increase your risk of overdose.
- You should stop Anoro Ellipta immediately and contact your doctor if you experience paradoxical bronchospasms.
- Caution should be used in patients with heart disease, prostate or bladder problems, seizures, thyroid dysfunction, glaucoma, or diabetes.
How long does Anoro Ellipta stay in your system?
Both active ingredients in Anoro Ellipta have a half-life of around 11 hours so they will stay in your circulation for over 2 days after the last dose.
How long does it take for Anoro Ellipta to start working?
Your lungs will absorb Anoro Ellipta within 5 to 15 minutes after inhalation and will last up to 24 hours.
Will I have withdrawal symptoms if I stop taking Anoro Ellipta?
You should not suddenly stop taking Anoro Ellipta without first discussing it with your doctor. Stopping Anoro Ellipta suddenly may cause a worsening of your symptoms.
Is it safe to use Anoro Ellipta while pregnant or breastfeeding?
There are no human studies evaluating the effects Anoro Ellipta may have during pregnancy or labor and delivery. Beta-agonists may interfere with uterine contractility so Anoro Ellipta should only be used during labor if the benefits outweigh the risks. There is no information available on whether Anoro Ellipta is found in human milk or the effects it may have on your breastfed child. Animal studies suggest that it is excreted in breast milk.
You should always discuss the risks and benefits of any medication with your healthcare provider if you are pregnant, plan on becoming pregnant, or are breastfeeding.
How should I store Anoro Ellipta?
You should store Anoro Ellipta at room temperature between 68°F and 77°F (20°C and 25°C) in a dry place away from sunlight. You should only open the foil tray when you are ready to use it. After using your inhaler, you can clean the mouthpiece using a dry tissue or paper towel. Anoro Ellipta should be disposed of 6 weeks after you open the tray or when the dose counter reads “0”, whichever comes first.
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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.