Crysvita Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Crysvita cost savings if eligible

The Crysvita patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Crysvita, regardless of the retail price.

Am I eligible for the Crysvita patient assistance program?

To find out if you are eligible for Crysvita assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Crysvita patient assistance program?

Our application process aims to make it as easy as possible to apply for the Crysvita patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Crysvita.

NiceRx will review your application and determine whether you may be eligible for Crysvita assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Crysvita patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period, we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Crysvita.

Is NiceRx a Crysvita coupons provider?

NiceRx is a service provider that helps eligible individuals access the Crysvita patient assistance program. We do not offer trial offers or free Crysvita samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Crysvita coupons, discount cards, or Crysvita copay cards.

Can NiceRx help me get Crysvita if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Crysvita medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Crysvita cost without insurance?

Crysvita prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Crysvita subcutaneous solution (10 mg/mL) typically costs $3,800 for a supply of 1 milliliter.

How much does Crysvita cost with insurance?

The copay for Crysvita will vary by the terms of your healthcare plan. To find out what you might need to pay for Crysvita with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Crysvita?

Crysvita (burosumab-twza), manufactured by Kyowa Kirin, Inc., is a fibroblast growth factor 23 (FGF23) blocking antibody with FDA approval (U.S. Food and Drug Administration) indicated for:

  • The treatment of X-linked hypophosphatemia (XLH) in adult and pediatric patients 6 months of age and older
  • The treatment of FGF23-related hypophosphatemia in tumor-induced osteomalacia (TIO) associated with phosphaturic mesenchymal tumors that cannot be curatively resected or localized in adult and pediatric patients 2 years of age and older

X-linked hypophosphatemia (XLH) is an inherited disorder with low levels of phosphate in the blood. Phosphate levels are low because phosphate is abnormally processed in the kidneys, causing a loss of phosphate in the urine, leading to soft, weak bones (rickets).

Tumor-induced osteomalacia (TIO) is a rare disease where we see the development of tumors that cause weakened and softened bones. The tumors release a peptide hormone-like substance known as fibroblast growth factor 23 (FGF23) that lowers phosphate levels.

What doses of Crysvita are available?

Crysvita is available in injection form, in the following doses: 10 mg/mL, 20 mg/mL, or 30 mg/mL in a single-dose vial.

For subcutaneous use only. The starting dose and ongoing treatment are based on the age and weight of the recipient.

Please see the full prescribing information and medication guide for additional Important Safety Information. Always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Crysvita active ingredients

Crysvita contains the active ingredient burosumab-twza.

Crysvita side effects

The most common side effects of Crysvita in clinical trials include:

  • Pediatric XLH patients – pyrexia, injection site reaction, cough, vomiting, pain in extremities, headache, tooth abscess, dental caries
  • Adult XLH patients – back pain, headache, tooth infection, restless legs syndrome, vitamin D decreased, dizziness, constipation, muscle spasms, increased blood phosphorus
  • TIO patients – tooth abscess, muscle spasms, dizziness, constipation, injection site reaction, rash, and headache

In rare instances, Crysvita can cause more serious adverse reactions. These can include:

  • Hypersensitivity – discontinue if serious hypersensitivity reactions occur and initiate appropriate medical treatment
  • Hyperphosphatemia
  • Nephrocalcinosis – dose interruption and/or reduction may be required based on a patient’s serum phosphorus levels
  • Injection site reactions – discontinue if severe injection site reactions occur and administer appropriate medical treatment

Your doctor will assess the benefits of using Crysvita against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Crysvita to the FDA. Visit, or call 1-800-FDA-1088.

Crysvita drug interactions

No drug interaction studies have been conducted with Crysvita. Talk to your caregivers about all the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements.

Crysvita contraindications

You should not use Crysvita if you:

  • Are allergic to the active ingredient burosumab-twza
  • Are allergic to any of the other ingredients in Crysvita
  • Have serum phosphorus levels within or above the normal range
  • Have severe renal impairment or end-stage renal disease

Talk to your doctor before using Crysvita if you:

  • Are taking any of the medications that could interact with Crysvita
  • Are taking oral phosphate and/or active vitamin D analogs (e.g. calcitriol, paricalcitol, doxercalciferol, calcifediol). Discontinue 1 week before treatment commences
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Crysvita generic

Crysvita is the trademark brand name for burosumab-twza manufactured by Kyowa Kirin, Inc. A generic version of burosumab-twza is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Crysvita savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.