Wixela Inhub Dosage, forms & strengths
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Wixela Inhub (fluticasone propionate and salmeterol inhalation powder) is a combination of an inhaled corticosteroid (ICS) and a long-acting beta-2 agonist (LABA) that is manufactured by Mylan Pharmaceuticals Inc. Wixela Inhub is FDA-approved for:
Wixela Inhub is not a replacement for your short-acting rescue inhaler such as Proventil HFA (albuterol HFA) and should not be used to treat sudden breathing problems.
How does Wixela Inhub work?
Wixela Inhub contains an inhaled corticosteroid (fluticasone propionate) and a LABA (salmeterol) that helps reduce symptoms of asthma and COPD. COPD is a group of conditions that includes emphysema and chronic bronchitis.
Fluticasone propionate reduces the inflammation in your lungs by blocking your immune system’s response to allergens (foreign substances). It does this through a variety of actions on inflammatory cell types such as mast cells and eosinophils and mediators such as histamines and leukotrienes.
Salmeterol is a long-acting beta-agonist that stimulates beta2-receptors found on the smooth muscle in your airways. Stimulation of these beta2-receptors causes the smooth muscle in your bronchioles to relax, which leads to bronchodilation and increased airflow in your lungs.
Wixela Inhub dosage forms and strengths
- Fluticasone propionate 100 mcg/salmeterol 50 mcg inhaler
- Fluticasone propionate 250 mcg/salmeterol 50 mcg inhaler
- Fluticasone propionate 500 mcg/salmeterol 50 mcg inhaler
Wixela Inhub dosage
- The recommended dose in the treatment of asthma in patients 4 to 11 years of age is 1 inhalation of Wixela Inhub 100mcg/50mcg 2 times a day.
- The recommended dose for the treatment of asthma in patients 12 years of age and older is 1 inhalation of Wixela Inhub 100mcg/50mcg, Wixela Inhub 250mcg/50mcg, or Wixela Inhub 500mcg/50mcg 2 times a day. Your initial dose will be based on the severity of your asthma symptoms.
- The recommended dose for the maintenance treatment of chronic obstructive pulmonary disease (COPD) is 1 inhalation of Wixela Inhub 250mcg/50mcg 2 times a day.
Wixela Inhub dosage restrictions
While there is no dose adjustment needed for patients with hepatic (liver) impairment, you should be closely monitored if you have liver disease. There is no data available on the effects of Wixela Inhub in patients with renal (kidney) impairment.
How to take Wixela Inhub
- Read the Full Prescribing Information, Instructions for Use, and Medication Guide that comes with this medication.
- Your healthcare professional should show you how to use your Wixela Inhub inhaler before you begin treatment. Children should use Wixela Inhub® with an adult’s help.
- You should use Wixela Inhub exactly as your healthcare professional prescribes it. Do not change your dose or stop taking Wixela Inhub without talking with them first.
- Wixela Inhub is taken twice a day at the same time each day, about 12 hours apart. Be sure to rinse your mouth with water without swallowing after each use to help prevent throat irritation and thrush.
- If you miss a dose of Wixela Inhub, skip the missed dose and take your next dose at the regularly scheduled time. Do not take extra doses of this medication to make up for any missed dose.
- Wixela should not be used in place of your rescue inhaler to treat sudden breathing problems. If you don’t have a rescue inhaler, contact your healthcare professional to have them prescribe one for you.
- If you think you have taken too much Wixela Inhub, call your healthcare professional immediately. If you have serious symptoms such as worsening shortness of breath, chest pain, or rapid heart rate, go to the nearest hospital emergency room.
- Store your Wixela Inhub inhaler at room temperature between 20° to 25°C (68° to 77°F) away from direct heat and sunlight. Leave the Wixela Inhub inhaler in the foil pouch until you are ready to use it. You should throw away your Wixela Inhub inhaler 1 month after opening the foil pouch or when the dose counter reads 0, whichever comes first.
Wixela Inhub dosage FAQs
What are the most common side effects of Wixela Inhub?
The most common adverse reactions of Wixela include:
- Upper respiratory tract infection
- Throat irritation or sore throat
- Oral candidiasis (thrush)
- Ocular herpes simplex (herpes infection of the eye)
- Joint and muscle pain
- Increased blood sugar (hyperglycemia)
Long-term use of Wixela Inhub can sometimes cause more serious adverse effects, including:
- Severe, life-threatening allergic reactions (hives, angioedema, and shortness of breath)
- Serious infection
- Increased risk of chickenpox or measles
- High blood pressure or other cardiovascular problems
- Increased risk of seizures
- Low potassium levels (hypokalemia)
Contact your doctor for medical advice about any adverse effects you experience while taking Wixela Inhub. You can report your side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
What drug interactions occur with Wixela Inhub?
When Wixela is taken with other medications, it may change the way they work or increase the frequency and severity of side effects. Discuss with your doctor whether any of the prescription drugs, over-the-counter medications, vitamins, and herbal supplements you take may interact with this medication, including:
- Strong CYP3A4 inhibitors such as indinavir, ketoconazole, saquinavir, ritonavir, itraconazole, and itraconazole
- Monoamine oxidase inhibitors (MAOIs) such as phenelzine
- Tricyclic antidepressants (TCAs) such as nortriptyline
- Beta-blockers such as metoprolol
- Non-potassium sparing diuretics such as furosemide
Are there any contraindications or precautions with Wixela Inhub?
Wixela Inhub should not be taken if you have any of the following conditions:
- Uncontrolled, severe asthma or COPD.
- Serious allergy to milk proteins or known hypersensitivity to any ingredients in this medication.
Caution should also be taken in the following situations:
- Do not use Wixela Inhub to treat asthma attacks or acute symptoms of COPD.
- Do not use this medication with other LABAs as it increases the risk of overdose.
- Wixela Inhub can cause immunosuppression which can lead to serious infections. Notify your healthcare provider if you have any signs of an infection.
- You should be slowly taken off of oral corticosteroids such as Deltasone (prednisone) when switching to Wixela Inhub.
- Your bone mineral density should be monitored at the start of Wixela Inhub treatment and periodically while on this medication.
- Pediatric patients should have their growth monitored.
- Wixela Inhub should be used with caution if you have glaucoma, cataracts, cardiovascular disease, CNS disorders, convulsive disorders, thyroid disease, diabetes, and ketoacidosis.
Can you take Wixela Inhub while you are pregnant or breastfeeding?
There is no sufficient data on the effects of Wixela Inhub use during pregnancy. It should be noted that pregnant women with poorly controlled asthma have an increased risk of complications to the fetus. There is also not sufficient data on whether Wixela Inhub is found in breast milk, the possible effects on the breastfed infant, or the effects on milk production. You should always discuss the risks and benefits of any medication with your healthcare provider if you are pregnant, plan on becoming pregnant, or are breastfeeding.
How often should you take Wixela Inhub?
Wixela Inhub is typically taken 2 times a day around the same time each day. The 2 doses should be taken around 12 hours apart. Make sure to rinse your mouth without swallowing after each use.
What is the maximum recommended dosage for Wixela Inhub?
The maximum recommended dose of Wixela Inhub is 500mcg/50mcg via oral inhalation twice daily.
Related resources for Wixela dosage:
Wixela Inhub research & news
The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.