Rheumatrex Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Is NiceRx a Rheumatrex coupon provider?

NiceRx is a service provider that helps eligible individuals access patient assistance programs. We do not offer trial offers or free Rheumatrex samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Rheumatrex coupons, discount cards, or Rheumatrex copay cards.

Rheumatrex patient assistance program

Patient assistance programs are typically sponsored by pharmaceutical companies and provide free or discounted medications to individuals with low income who are uninsured or under-insured and meet the eligibility criteria that vary by program. There are currently no known patient assistance programs for this medication.

How much does Rheumatrex cost without insurance?

Rheumatrex prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Rheumatrex oral tablets 2.5 mg typically cost $90 for 8 tablets.

How much does Rheumatrex cost with insurance?

The copay for Rheumatrex will vary by the terms of your healthcare plan. To find out what you might need to pay for Rheumatrex with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Rheumatrex?

Rheumatrex is an FDA (U.S. Food and Drug Administration) approved medication manufactured by DAVA Pharmaceuticals, Inc.

Rheumatrex is an antimetabolite used to treat gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole, acute lymphocytic leukemia, meningeal leukemia, breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides, lung cancer, advanced non-Hodgkin’s lymphomas, and osteosarcoma. It is also used for the treatment of severe psoriasis or rheumatoid arthritis that has not been treated adequately with other treatments. It may also be used to treat juvenile rheumatoid arthritis.

What doses of Rheumatrex are available?

Rheumatrex is available in tablet form, in the following doses: 2.5 mg.

Methotrexate can lower levels of folate in your body. Take folic acid supplements with methotrexate to prevent a folate deficiency. Folate deficiency can lead to symptoms such as fatigue, muscle weakness, mouth ulcers, and neurological symptoms.

Please read the instructions for use supplied with your medicine and always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.

Rheumatrex active ingredients

Rheumatrex contains methotrexate as the active ingredient.

Rheumatrex side effects

The most common side effects of Rheumatrex in clinical trials include:

  • Nausea, stomach pain, dyspepsia, diarrhea, vomiting
  • Stomatitis/mouth sores, rash, nasopharyngitis, sore throat
  • Hair loss
  • Abnormalities in liver function tests, as detected by blood tests
  • Headache, dizziness, drowsiness
  • Bronchitis
  • Thrombocytopenia, leucopenia, pancytopenia
  • Photosensitivity, and burning of skin lesions

In rare instances, Rheumatrex can cause more serious side effects. These can include:

  • Bone marrow, liver, lung, skin, and kidney toxicities
  • Fetal death and/or birth defects
  • Unexpectedly severe (sometimes fatal) bone marrow suppression, aplastic anemia, and gastrointestinal toxicity when given with some nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Hepatotoxicity, fibrosis, and cirrhosis
  • Methotrexate-induced lung disease
  • Interstitial pneumonitis at any time during therapy and has been reported at low doses
  • Pulmonary symptoms – dry cough may require interruption of treatment and investigation
  • Diarrhea, ulcerative stomatitis, hemorrhagic enteritis, and death from intestinal perforation
  • Severe, occasionally fatal, skin reactions
  • Potentially fatal opportunistic infections

Stop taking Rheumatrex and call your doctor if you get diarrhea, mouth sores, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.

Your doctor will assess the benefits of using Rheumatrex against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Rheumatrex to the FDA. Visit, or call 1-800-FDA-1088.

Rheumatrex drug interactions

Rheumatrex can interact with other medications. These include:

  • Retinoids such as isotretinoin
  • NSAIDs
  • Steroids – prednisone
  • Proton pump inhibitors – esomeprazole, lansoprazole, omeprazole, pantoprazole
  • Other drugs that can cause liver problems such as azathioprine, sulfasalazine
  • Penicillins
  • Phenytoin
  • Probenecid
  • Sulfa medications
  • Tetracyclines
  • Theophylline
  • Certain vaccinations

This list is not exhaustive and other prescription drugs may interact with Rheumatrex. Tell your healthcare provider about all of the medicines you take, including prescription, over-the-counter medicines, vitamins, and herbal supplements.

Rheumatrex contraindications

You should not use Rheumatrex if you:

  • Are allergic to the active ingredient methotrexate
  • Are allergic to any of the other ingredients in Rheumatrex
  • Suffer from alcoholism
  • Have liver disease
  • Have low blood cell counts
  • Have a weak immune system
  • Are pregnant or are planning to become pregnant – Women must use birth control while taking Rheumatrex and for some time after the last dose

Talk to your doctor before using Rheumatrex if you:

  • Are taking any of the medications that could interact with Rheumatrex
  • Have anemia, leukopenia, or thrombocytopenia (low platelet blood level)
  • Have renal impairment
  • Have pleural effusion
  • Have diabetes
  • Have ulcerative colitis
  • Are breastfeeding or are planning to breastfeed

Rheumatrex generic

Rheumatrex is the trademark brand name for methotrexate manufactured by DAVA Pharmaceuticals, Inc. A generic version of methotrexate is available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Rheumatrex savings through NiceRx.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.