Trelegy Ellipta Dosage, forms & strengths
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Get started todayTrelegy Ellipta is a combination of 3 different medications that is manufactured by GlaxoSmithKline (GSK) for the treatment of COPD and asthma symptoms. It contains a muscarinic antagonist (umeclidinium), an inhaled corticosteroid (fluticasone furoate), and a long-acting beta-2 adrenergic agonist (vilanterol trifenatate). The active ingredients of Trelegy Ellipta are in separate blisters in powder form inside the device.
Trelegy Ellipta is FDA-approved for the maintenance treatment of adults with chronic obstructive pulmonary disease (COPD) and asthma.
Trelegy works by 3 different mechanisms of action. Fluticasone is an ICS that helps to decrease swelling in your lungs by switching off multiple activated inflammatory genes. Umeclidinium bromide is an anticholinergic medication that causes bronchodilation by blocking the M3 receptor in your lungs. Vilanterol is a long-acting beta2-agonist (LABA) that helps improve lung function by relaxing the smooth muscles in your airways.
Your Trelegy Ellipta inhaler is not a rescue inhaler like Ventolin (albuterol). It should not be used for asthma exacerbations. You will still need your rescue inhaler to treat sudden breathing problems.
Trelegy Ellipta dosage forms and strengths
Trelegy Ellipta is available as an inhalation powder in the following strengths:
- 100 mcg/62.5 mcg/ 25 mcg per actuation
- 200 mcg/62.5 mcg/ 25 mcg per actuation
Trelegy Ellipta dosage
One actuation of Trelegy Ellipta is typically taken once a day, at the same time each day. You should not use Trelegy Ellipta more than once every 24 hours.
Trelegy Ellipta adult dosage chart
| Indication | Starting dosage | Standard dosage | Maximum dosage |
|---|---|---|---|
| Chronic obstructive pulmonary disease (COPD) | 1 actuation (100mcg/62.5mcg/25mcg) by oral inhalation once a day. | 1 actuation (100mcg/62.5mcg/25mcg) by oral inhalation once a day. | 1 actuation (100mcg/62.5mcg/25mcg) by oral inhalation once a day. |
| Asthma | 1 actuation (100mcg/62.5mcg/25mcg) by oral inhalation once a day. | 1 actuation (100mcg/62.5mcg/25mcg or 200mcg/62.5mcg/25mcg) by oral inhalation once a day. | 1 actuation (200mcg/62.5mcg/25mcg) by oral inhalation once a day. |
The safety and efficacy of Trelegy Ellipta have not been established in adolescents and children aged 18 years and younger.
Trelegy Ellipta dosage restrictions
- Use Trelegy Ellipta with caution in patients with moderate to severe hepatic impairment. They should be monitored for systemic corticosteroid effects.
- There is no dosage adjustment required for patients with renal impairment.
How to take Trelegy Ellipta
- Read the Full Prescribing Information, Instructions for Use, and Medication Guide that comes with Trelegy Ellipta.
- Your healthcare provider should show you how to properly use your Trelegy Ellipta inhaler before you begin treatment.
- Use your Trelegy Ellipta inhaler exactly as your healthcare provider prescribes it. Do not change your dose or stop taking Trelegy Ellipta without discussing it with them.
- Use 1 actuation of Trelegy Ellipta once a day at the same time each day.
- If you miss a dose of Trelegy Ellipta, take it immediately and then take the next dose at your regular time. Do not take more than 1 inhalation of Trelegy Ellipta in 24 hours.
- If you think you have taken too much Trelegy Ellipta, call your healthcare provider for medical advice or go to the nearest emergency room if you have symptoms such as worsening shortness of breath, chest pain, or increased heart rate.
- Trelegy Ellipta does not replace your rescue inhaler. You should always keep one with you to treat sudden symptoms.
- Store Trelegy Ellipta at room temperature between 68°F to 77°F (20°C to 25°C), away from heat and sunlight. Trelegy Ellipta should be stored in the unopened tray until it is ready for use. Trelegy Ellipta should be discarded 6 weeks after the tray has been opened or if the counter reaches “0” before 6 weeks have passed.
Trelegy Ellipta dosage FAQs
What are some common side effects of Trelegy Ellipta?
Some common possible side effects (incidence ≥1%) of Trelegy Ellipta include:
- Headache
- Upper respiratory tract infection
- Back pain
- Nasopharyngitis
- Diarrhea
- Sore throat
- Constipation
- Urinary tract infection
- Fungal infection in the mouth (oropharyngeal candidiasis)
- Sinusitis
- Bronchitis
- Voice disorder (dysphonia)
- Dry mouth
- Joint pain
- Blurred vision
- Hyperglycemia
Trelegy Ellipta can cause serious adverse reactions including:
- Increased heart rate
- Hypertension (high blood pressure)
- Worsening of COPD (bronchitis and emphysema) or asthma symptoms
- Reduced bone mineral density (osteoporosis)
- Urinary retention
- Hypokalemia (low potassium levels)
- Eye pain
- Glaucoma
- Cataracts
- Life-threatening hypersensitivity reactions, including hives, swelling, or trouble breathing
Contact your healthcare provider about any side effects or worsening symptoms you experience while taking Trelegy Ellipta. You can report your side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
What are some drug interactions with Trelegy Ellipta?
When Trelegy Ellipta is taken with other medications, they may interact and change how they work. They can also change the frequency and severity of certain side effects. Make sure your healthcare provider is aware of all prescription and over-the-counter medications, vitamins, and herbal supplements you take, including:
- Strong CYP3A4 inhibitors such as Norvir (ritonavir), Nizoral (ketoconazole), and Biaxin XL (clarithromycin)
- Monoamine oxidase inhibitors (MAOIs) such as Nardil (phenelzine)
- Tricyclic antidepressants (TCAs) such as Elavil (amitriptyline)
- Beta-blockers such as Lopressor (metoprolol)
- Diuretics such as Lasix (furosemide)
- Other anticholinergic medications such as Spiriva (tiotropium)
Are there any contraindications or precautions with Trelegy Ellipta?
- You should not take Trelegy Ellipta if you have had an allergic reaction to Trelegy Ellipta or any of its inactive ingredients which include milk proteins and magnesium stearate.
- Trelegy Ellipta should not be used if you have worsening or severe asthma or COPD symptoms.
- Use Trelegy Ellipta with caution in patients with narrow-angle glaucoma.
- Trelegy Ellipta contains a LABA, vilanterol. LABAs, when used as monotherapy increase the risk of severe asthma-related complications.
- Adrenal dysfunction may occur with Trelegy Ellipta.
- Trelegy Ellipta can cause difficulties in passing urine.
- Inhaled Trelegy Ellipta can weaken your immune system like oral corticosteroids.
- If paradoxical bronchospasm occurs, you should stop Trelegy Ellipta immediately and start an alternative treatment.
How long does it take for Trelegy Ellipta to start working?
In clinical studies, patients taking Trelegy Ellipta saw an improvement in breathing test (FEV1) scores with their first dose, but it took several weeks for them to see the full effects.
How long does Trelegy Ellipta stay in your system?
Trelegy Ellipta has 3 ingredients whose half-lives are between 11 and 24 hours and will stay in your circulation for up to 5 days after the last dose.
Is it safe to use Trelegy Ellipta while pregnant or breastfeeding?
There is insufficient data on the use of Trelegy Ellipta during pregnancy. It should only be used if the potential benefit justifies the potential risks. There is no data on whether Trelegy Ellipta is found in breast milk or any adverse effects it may have on the infant or milk production. You should always discuss the risks and benefits of any medication with your healthcare provider if you are pregnant, plan on becoming pregnant, or are breastfeeding.
Will lab monitoring be done when taking Trelegy Ellipta?
There are a few labs your healthcare provider may run before or during treatment with Trelegy Ellipta. Your bone mineral density should be monitored initially and then periodically after beginning treatment. You may also be monitored for high potassium and blood sugar levels.
You should also watch out for symptoms of glaucoma, thyroid disease, infections, convulsive disorders, and urinary retention.
Is there a generic for Trelegy Ellipta?
Currently, there is no generic for Trelegy Ellipta available on the market. However, you can still save on brand-name drugs like Trelegy Ellipta with NiceRx if eligible.
Related resources for Trelegy Ellipta dosage
- https://reference.medscape.com/drug/trelegy-ellipta-fluticasone-furoate-umeclidinium-bromide-vilanterol-inhaled-1000165
- https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Trelegy_Ellipta/pdf/TRELEGY-ELLIPTA-PI-PIL-IFU.PDF
- https://www.trelegyhcp.com/
- https://www.pdr.net/drug-summary/Trelegy-Ellipta-fluticasone-furoate-umeclidinium-vilanterol-24141#14
