Xyrem Coupon & Prices

Is your Xyrem medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Xyrem medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

How it works

  • Enroll online

    Get started by filling out the online enrollment application to find out if you are eligible for assistance.

  • Pre-qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.

  • Submit documents

    We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.

  • Receive medication

    Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Xyrem cost savings if eligible

If you are eligible for the Xyrem patient assistance program, the cost of your medication will be free. We only charge $49 a month, per medication, to cover our service fees. You could receive your Xyrem prescription for just $49 a month, regardless of the retail price of your medication.

Am I eligible for the Xyrem patient assistance program?

We will review your application to determine whether you are eligible for the Xyrem patient assistance program. Each program has its own eligibility criteria which is set by the pharmaceutical companies, however the factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Xyrem patient assistance program?

We make it as easy as possible to apply for the Xyrem patient assistance program. The first step is to complete our enrollment application. Tell us about any medications you are taking, including Xyrem. We will also ask for details about your healthcare provider, insurance, and your household income. This information is required by the pharmaceutical manufacturers who ship your medication.

If we determine that you may be eligible for Xyrem assistance, we will handle the application process for you. We will work directly with your healthcare provider to prepare your application documents. Once we have received the signed application and supporting documents, we will submit them to the patient assistance program on your behalf. Our service continues once you are enrolled in the Xyrem patient assistance program, and we will automatically request your Xyrem medication refills for up to 1 year.

Is NiceRx a Xyrem coupons provider?

We are a service provider that helps eligible individuals access the Xyrem patient assistance program. That means that we do not offer printable Xyrem manufacturer coupons, Xyrem discounts, or free Xyrem samples. We are not a Xyrem coupon provider or Xyrem discount card. Our service extends to assisting eligible individuals to access the medications they need through patient assistance programs.

Can NiceRx help me get Xyrem if I have insurance?

We may be able to help you to access Xyrem patient assistance in a variety of circumstances. This includes when your insurance company will not pay for your Xyrem medication or if you have a high copay or coinsurance responsibility. We may also be able to help you if you do not have insurance. Please apply online to find out more.

How much is Xyrem with insurance?

The cost of Xyrem with insurance depends on the terms of your healthcare plan. To find out how much this is, your healthcare provider or pharmacist will be able to calculate your copay with your current insurance.

How much does Xyrem cost without insurance?

Xyrem prices without insurance will vary depending on where you buy it. As a guide, one 180 ml bottle of Xyrem oral liquid (500 mg/ml) usually costs around $5,800. With NiceRx you will pay a flat monthly fee of $49, regardless of the retail price of your medication.

What is Xyrem?

Xyrem is a prescription medication used to treat narcolepsy. It is prescribed to adults and children 7 years and over to treat the symptoms of:

  • The sudden onset of weak or paralyzed muscles (cataplexy)
  • Excessive daytime sleepiness (EDS)

If you have or your child has narcolepsy your doctor may have prescribed Xyrem. Xyrem is a prescription medication taken as an oral solution. Your doctor or pharmacist will show you how to prepare Xyrem and what dose should be taken. The medication acts as a central nervous system depressant that can significantly reduce cataplexy and daytime sleepiness.

More information on what is Xyrem and Xyrem dosage

Xyrem active ingredients

The active ingredient in Xyrem is called sodium oxybate, a type of central nervous system depressant. Research has shown that sodium oxybate can significantly reduce cataplexy and daytime sleepiness caused by narcolepsy.

It is not fully understood how sodium oxybate does this, but it is thought that it binds to cells in your brain (neurons) at sites called receptors. This stimulates the receptors and may alter brain function in a way that reduces cataplexy and daytime sleepiness.

Xyrem side effects

The most common Xyrem side effects include:

  • Headaches
  • Dizziness
  • Tremors
  • Feeling sick (nausea)
  • Vomiting
  • A decrease in appetite
  • Weight loss
  • Sleepwalking
  • Wetting the bed

In rarer instances Xyrem can cause more serious side effects, like:

  • Severe allergic reactions to the medication
  • Breathing problems, including slower breathing and stopping breathing for short periods of time
  • A worsening of or new mental health (psychiatric) problems, including depression, anxiety, aggressive behaviors, hallucinations, mania, and suicidal thoughts and behaviors
  • Falls and injuries caused by sleepwalking
  • Sleepwalking, waking and confused behavior at night

Xyrem drug interactions

Xyrem can interact with other medications. Tell your prescribing doctor about all drugs you are taking, particularly any other central nervous system (CNS) depressants. These include:

  • Antipsychotics – risperidone, quetiapine, and olanzapine
  • Benzodiazepines – temazepam, diazepam, and lorazepam
  • General anesthetics – etomidate, ketamine, and propofol
  • Muscle relaxants – baclofen, carisoprodol, and dantrolene
  • Opioid analgesics – codeine, morphine and tramadol
  • Sleeping pills – triazolam and zolpidem
  • Anti-anxiety medication – citalopram and sertraline
  • Sedating antidepressants – doxepin and trazodone
  • Street drugs/recreational drugs – heroin
  • Any medications that contain divalproex sodium, like Depakote, Depakote DR, Depakote ER, or Depakote Sprinkles used to treat epilepsy, bipolar disorder, schizophrenia, and migraines

This list is not exhaustive and other drugs may interact with Xyrem.

Xyrem warning and precautions

Xyrem is a federally controlled substance. It can be prescribed to treat narcolepsy, but it can cause physical or psychological dependence. Xyrem can also be abused. Always take your Xyrem exactly as described to minimize the chances of this happening. Never give or sell your Xyrem to another person.

Xyrem can cause side effects like dizziness and confusion that can affect your ability to drive, use machinery, or perform other dangerous tasks. Avoid these activities until at least 6 hours after taking Xyrem and until you are confident it does not affect you in this way.

Do not drink alcohol when taking Xyrem, as it can enhance the sedative effects of the medication and can make it difficult to stay awake, focus, and breathe. Xyrem should not be given to anyone under 7 years old. Do not take Xyrem if you:

  • Are allergic to the active ingredient sodium oxybate
  • Are allergic to any of the other ingredients in Xyrem
  • Drink alcohol
  • Have a rare condition called succinic semialdehyde dehydrogenase deficiency

Talk to your doctor before taking Xyrem if you:

  • Are taking any of the medications that could interact with Xyrem
  • Have a history of mental health problems
  • Have a history of drug or alcohol addiction/abuse
  • Have heart failure
  • Have sleep apnea (short periods of not breathing while sleeping) or any other breathing problems
  • Have high blood pressure (hypertension)
  • Have any liver problems
  • Have any kidney problems
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Related medications

Related conditions

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.