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Tresiba vs Lantus

Drug facts and comparison

Uses

  • Type 1 diabetes in adults and children one year and older
  • Type 2 diabetes in adults and children one year and older
Get Tresiba for only
$49 per month
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  • Type 1 diabetes in adults and children six years and older
  • Type 2 diabetes in adults
Get Lantus for only
$49 per month
Get started

Summary

Brand name: Tresiba
Brand name: Lantus
Manufacturer: Novo Nordisk
Manufacturer: Sanofi-Aventis
Active ingredient: Insulin degludec
Active ingredient: Insulin glargine
Indication: Type 1 diabetes in adults and children 1 year and older. Type 2 diabetes in adults and children 1 year and older
Indication: Type 1 diabetes in adults and children 6 years and older. Type 2 diabetes in adults
Frequency of injection: Once per day
Frequency of injection: Once per day
Duration of action: Up to 42 hours
Duration of action: Up to 24 hours
Injection method: Tresiba FlexTouch Pen Syringe
Injection method: Lantus SoloStar Pen Syringe
Average cost per 10 ml, 100 unit vial: $360
Average cost per 10 ml, 100 unit vial: $306

Side Effects

Most common

  • Reactions at the site of injection, like itching, rashes, skin thickening, or pits forming in your skin (lipodystrophy)
  • Allergic reactions
  • Weight gain
  • Swelling of your hands and feet

More serious

  • Heart failure (more likely if used alongside a thiazolidinedione diabetes medication)
  • Severe allergic reactions to the medication can cause anaphylaxis
  • Your blood sugar falling too low to dangerous levels (hypoglycemia)
  • Low potassium levels in your blood (hypokalemia)

Most common

  • Reactions at the site of injection, like itching, rashes, skin thickening, or pits forming in your skin (lipodystrophy)
  • Allergic reactions
  • Weight gain
  • Low blood sugar (hypoglycemia)

More serious

  • Heart failure (more likely if used alongside a thiazolidinedione diabetes medication)
  • Severe allergic reactions to the medication can cause anaphylaxis
  • Your blood sugar falling too low to dangerous levels (hypoglycemia)
  • Low potassium levels in your blood (hypokalemia)

Drug Interactions

1 Severe Interaction
  • Antibiotics for bacterial infections such as ciprofloxacin, enoxacin, norfloxacin, and ofloxacin
14 Serious interactions
  • Thiazolidinedione medications (TZDs) such as pioglitazone and rosiglitazone, taken to treat diabetes
  • Any other diabetes medications – metformin, glipizide
  • Beta-blockers, taken to treat high blood pressure – propranolol, sotalol
  • Angiotensin-converting enzyme (ACE) inhibitors, taken to treat high blood pressure and certain heart conditions – captopril, enalapril
  • Guanethidine and reserpine, taken to treat high blood pressure
  • Diuretics, taken to make you lose water and salt, usually to treat high blood pressure – bumetanide, furosemide
  • Clonidine, taken to treat a range of conditions including high blood pressure
  • Corticosteroids such as cortisone and prednisolone
  • Fenofibrate, taken to lower blood triglyceride levels
  • Angiotensin II receptor blockers, taken to treat high blood pressure, diabetic kidney damage, and heart failure – candesartan, losartan, valsartan
  • Beta 2-stimulants, taken to treat asthma – salmeterol
  • Antidepressants, including monoamine oxidase inhibitors and selective serotonin reuptake inhibitors – phenelzine, selegiline, sertraline
  • Disopyramide, taken to treat heart rhythm problems
  • Estrogen containing drugs including birth control and hormone replacements
2 Moderate Interactions
  • Steroids used topically (on the skin) such as betamethasone, clobetasol, hydrocortisone, and mometasone
  • Diltiazem, used for the treatment of high blood pressure
1 Severe Interaction
  • Antibiotics for bacterial infections such as ciprofloxacin, enoxacin, norfloxacin, and ofloxacin
14 Serious Interactions
  • Thiazolidinedione medications (TZDs) such as pioglitazone and rosiglitazone, taken to treat diabetes
  • Any other diabetes medications – metformin, glipizide
  • Beta-blockers, taken to treat high blood pressure – propranolol, sotalol
  • Angiotensin-converting enzyme (ACE) inhibitors, taken to treat high blood pressure and certain heart conditions – captopril, enalapril
  • Guanethidine and reserpine, taken to treat high blood pressure
  • Diuretics, taken to make you lose water and salt, usually to treat high blood pressure – bumetanide, furosemide
  • Clonidine, taken to treat a range of conditions including high blood pressure
  • Corticosteroids such as cortisone and prednisolone
  • Fenofibrate, taken to lower blood triglyceride levels
  • Angiotensin II receptor blockers, taken to treat high blood pressure, diabetic kidney damage, and heart failure – candesartan, losartan, valsartan
  • Beta 2-stimulants, taken to treat asthma – salmeterol
  • Antidepressants, including monoamine oxidase inhibitors and selective serotonin reuptake inhibitors – phenelzine, selegiline, sertraline
  • Disopyramide, taken to treat heart rhythm problems
  • Estrogen containing drugs including birth control and hormone replacements
2 Moderate Interactions
  • Steroids used topically (on the skin) such as betamethasone, clobetasol, hydrocortisone, and mometasone
  • Diltiazem, used for the treatment of high blood pressure

Warnings

You should not use Tresiba if you:

  • Are allergic to the active ingredient insulin degludec
  • Are allergic to any of the other ingredients in Tresiba
  • Are under 1 year of age for type 1 diabetes
  • Are under 1 year of age for type 2 diabetes
  • Have diabetic ketoacidosis – a condition where high blood sugar causes high levels of ketones to build up in your body

You should talk to your doctor before using Tresiba if you:

  • Are taking any of the medications that could interact with Tresiba
  • If you suffer from low blood sugar (hypoglycemia)
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

You should not use Lantus if you:

  • Are allergic to the active ingredient insulin glargine
  • Are allergic to any of the other ingredients in Lantus
  • Are under 6 years of age for type 1 diabetes
  • Are under 18 years of age for type 2 diabetes
  • Have diabetic ketoacidosis – a condition where high blood sugar causes high levels of ketones to build up in your body

You should talk to your doctor before using Lantus if you:

  • Are taking any of the medications that could interact with Lantus
  • Have any heart problems
  • Have any have liver or kidney problems
  • Have low levels of potassium in your blood
  • If you suffer from low blood sugar (hypoglycemia)
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed
  • Are over 65 years of age

Dosage

Once per day

Once per day

Cost

A 10 ml, 100 unit vial of Tresiba costs approximately $363

A 10 ml, 100 unit vial of Lantus costs approximately $306

Injectable insulins like Tresiba and Lantus are an effective treatment for type 1 and type 2 diabetes. Whilst your doctor will be able to prescribe the best possible insulin for your condition, it is important to know the differences between them. To help, here we explain clearly and simply what Lantus and Tresiba are, how they work, and the similarities and differences between them.

Understanding insulin and long acting insulin

Insulin is a natural hormone your body produces. It helps your cells absorb glucose from your blood and makes sure you maintain a healthy blood glucose level. Lantus and Tresiba are both synthetic (man-made) versions of insulin. Whilst they work in the same way as the insulin your body naturally produces, they are designed to be longer acting.

Tresiba and Lantus are usually injected once a day to help your body maintain a healthy blood glucose level throughout the day and night. They are active for 24 hours after injecting, often for longer, depending on the dose you take.

What is the difference between Lantus and Tresiba?

Tresiba and Lantus are both long-acting insulins used to treat diabetes. The medications are similar, but there are some key differences between Lantus and Tresiba.

  • Tresiba and Lantus are both prescribed to treat type 1 and type 2 diabetes in adults. Lantus has only been approved to treat type 1 diabetes in children 6 years and over, while Tresiba has been approved to treat both type 1 and type 2 diabetes in children aged 1 year and older.
  • Tresiba and Lantus contain different types of insulin. Tresiba contains insulin degludec and Lantus contains insulin glargine.
  • Tresiba is longer-lasting than Lantus. Lantus typically lasts for 24 hours, but Tresiba can last up to 42 hours depending on the dose taken.
  • Lantus and Tresiba can cause similar side effects. However, research has shown Tresiba is less likely to cause hypoglycemia (when your blood glucose levels fall too low). Tresiba may be more suitable for people who are prone to hypoglycemia.
  • Although insulins can interact with similar medications, Tresiba has a longer list of medications that should be avoided.
  • Lantus is generally cheaper than Tresiba. A 10 ml, 100 unit vial of Tresiba costs approximately $363, whilst a 10 ml, 100 unit vial of Lantus costs approximately $306.

How effective is Tresiba vs Lantus?

Both Lantus and Tresiba are proven to be effective treatments for type 1 and type 2 diabetes, but which is the most effective?

Two reviews of the research into the effectiveness of Tresiba and Lantus (one covering 15 trials and 16,694 patients and the other covering 18 trials and 16,791 patients) found both medications reduced blood glucose by a comparable amount. Both reviews found that Tresiba was less likely to cause hypoglycemia and concluded that it may be more suitable for patients who are prone to hypoglycemia.

Tresiba vs Lantus cost comparison

Both Lantus and Tresiba can be bought as:

  • Pre-filled self-injecting pens
  • Cartridges for use in self-injecting pens
  • Vials of insulin to be used in a syringe

The cost of Tresiba and Lantus without insurance can vary by retailer and the amount you buy. It will also depend on whether you buy pre-filled pens, cartridges, or vials. Based on average prices for a comparable amount of each medication, Lantus is generally cheaper than Tresiba.

The cost of Lantus and Tresiba, if you have insurance, will depend on the details of your healthcare plan. Contact your pharmacist or insurance provider to calculate your copay with your current insurance.

If you’re approved for Lantus or Tresiba assistance through NiceRx, you could get your prescription for only $49 per month. We may be able to help you even if you have insurance. Fill in our online enrollment application to find out more.

Tresiba vs Lantus FAQs

FAQs

Is Tresiba the same as Lantus?

Lantus and Tresiba are both long-acting insulins prescribed to treat type 1 and type 2 diabetes. They can both help you manage your blood sugar level over a 24-hour period, but they are not the same insulin. They each contain a different form of insulin. Lantus contains insulin glargine and Tresiba contains insulin degludec, meaning they may affect you differently.

Can you switch from Lantus to Tresiba?

Although both Tresiba and Lantus are long-acting insulins that work similarly, they are different forms of insulin. This means that they are not interchangeable. If your doctor has prescribed either Tresiba or Lantus to you, you should take the one prescribed and not switch one for the other.

What insulin is equivalent to Tresiba?

Tresiba is a long-acting insulin that helps you manage your blood glucose throughout the day and night. Other long-acting insulins include LantusLevemirBasaglar, and Toujeo. These insulins all contain a different form of insulin but work in a similar way and last for a similar amount of time.

Does Tresiba make you gain weight?

Tresiba can make you gain weight. Not everyone who takes Tresiba will gain weight, but weight gain is a common side effect of all insulins. Talk to your doctor about ways you can prevent or minimize weight gain if you have been prescribed Tresiba.

Is it safe to take Lantus and Tresiba when pregnant?

There is no conclusive research on the effects of Lantus or Tresiba on pregnant women. Insulin may affect an unborn baby, but high blood sugar levels during pregnancy are also dangerous for both the mother and baby. Insulins like Lantus or Tresiba may also lower the risk of diabetes complications. Talk to your doctor if you are taking insulin and you are pregnant or are trying to become pregnant.

Is Tresiba cheaper than Lantus?

The cost of Tresiba and Lantus will vary by retailer. Whether you buy pre-filled pens, cartridges, or vials of insulin will also affect the price. However, when comparing similar amounts and forms of Tresiba and Lantus, Tresiba is usually more expensive than Lantus.

Both Tresiba and Lantus are similar long-acting insulins used to treat type 1 and type 2 diabetes. They are not the same however. With key differences between them, it is important to always take the one that has been prescribed to you.

If you would like to change for any reason you should speak to your doctor and follow their advice. If your doctor has prescribed Lantus or Tresiba to you, you may be able to receive your insulin for only $49 per month with NiceRx. Complete our online enrollment application to find out if you are eligible for Tresiba or Lantus assistance.