Farxiga Dosage, forms & strengths
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Farxiga (dapagliflozin) is a prescription sodium-glucose co-transporter 2, or SGLT2 inhibitor that is manufactured by AstraZeneca. It is U.S. Food and Drug Administration (FDA)-approved:
- In addition to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (T2DM).
- To reduce the risk of hospitalization for heart failure in adults with T2DM and either established cardiovascular disease or multiple cardiovascular risk factors.
- To reduce the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure with reduced ejection fraction (NYHA class II-IV).
- To reduce the risk of sustained estimated glomerular filtration rate (eGFR) decline, end-stage kidney disease, cardiovascular death, and hospitalization for heart failure in adults with chronic kidney disease (CKD) at risk of progression.
Farxiga is not approved for the treatment of type 1 diabetes (T1DM), diabetic ketoacidosis (DKA), or chronic kidney disease (CKD) in patients with polycystic kidney disease.
Farxiga dosage forms and strengths
Farxiga is available as an oral film-coated tablet in the following strengths:
Farxiga dosage for adults
The recommended starting dose of Farxiga in adults is 5mg to 10 mg by mouth once daily, depending on your estimated glomerular filtration rate (eGFR). Farxiga can be taken with or without food. The safety and effectiveness of Farxiga have not been established in pediatric patients under 18 years of age.
Farxiga adult dosage chart
|eGFR (ml/min/1.73m2)||Recommended dose
|eGFR 45 and greater||5mg once daily. The dose can be increased to 10mg once daily if additional blood sugar control is needed.
|eGFR 25 to less than 45 (severe renal impairment)||Initiating Farxiga therapy is not recommended, however, you may continue 10mg once daily.
Farxiga dosage restrictions
- Use of Farxiga for glycemic control in patients with T2DM without established heart disease or CV risk factors is not recommended if the eGFR is less than 45 mL/min/1.73 m^2.
- There is no dose adjustment necessary in patients with mild, moderate, or severe hepatic impairment.
How to take Farxiga
- Take Farxiga exactly as your healthcare provider prescribes it to you. Do not change your Farxiga dose without talking to your healthcare provider.
- Read the Full Prescribing Information and Medication Guide provided by your pharmacist before you start taking Farxiga and with each refill.
- Farxiga is taken by mouth once a day, with or without food.
- Stick to your prescribed diet and exercise program while taking Farxiga.
- Farxiga can cause your urine to test positive for glucose.
- Your doctor may perform blood tests to measure your kidney function, blood sugar levels, and HbA1c levels before you start Farxiga and during treatment.
- If you miss a dose, take it immediately. If it is almost time for your next dose, skip the missed dose and take Farxiga at your next regularly scheduled time. Do not take extra doses of Farxiga to make up for a missed dose.
- If you take too much Farxiga, call your healthcare professional for medical advice or go to the nearest emergency room immediately.
Farxiga dosage FAQs
What are some side effects of Farxiga?
Some common adverse reactions of Farxiga may include:
- Urinary tract infections such as urosepsis and pyelonephritis
- Female genital mycotic infections (yeast infection)
- Back pain
- Increased urination
- Weight loss
Some serious side effects of Farxiga include:
- Ketoacidosis (increased ketones in your blood or urine)
- Volume depletion
- Fournier’s Gangrene (rare but life-threatening bacterial infection in your genital/anal area)
- Low blood sugar if given with other diabetes medications such as Glucotrol (glipizide)
- Severe hypersensitivity reactions
You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.
What are some drug interactions with Farxiga?
Taking Farxiga with other medications can interact and change how those work. It may also increase the frequency and severity of certain side effects. Make sure your doctor is aware of all the medications you take, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Some major drug interactions of Farxiga include:
- Diuretics can cause an increase in urine frequency and volume, which may lead to volume depletion or low blood pressure (hypotension).
- Insulin secretagogues (sulfonylurea) or insulin increase your risk of hypoglycemia (low blood sugar).
Are there any contraindications or precautions with Farxiga?
You should not take Farxiga if you:
- Are allergic to Farxiga or any of its inactive ingredients.
- Are on dialysis.
How long does Farxiga stay in the system?
Farxiga has a half-life of around 13 hours following a single oral 10mg dose. It will remain in your bloodstream for a little over 2.5 days.
What is the maximum dosage for Farxiga?
The maximum dose of Farxiga is 10mg once daily, with or without food.
Is it safe to use Farxiga while pregnant or breastfeeding?
Farxiga is not recommended during the second or third trimesters of pregnancy based on adverse effects seen during animal studies. It is unknown if Farxiga is found in breast milk but because of the possibility of adverse effects, it is not recommended to be used during lactation.
Will lab monitoring be done when taking Farxiga?
While on Farxiga, you should monitor your blood glucose levels regularly. You should be able to recognize the signs and symptoms of hypoglycemia (sweating, increased heart rate, shakiness, dizziness). Your doctor may also monitor your glycemic control with a hemoglobin A1c (HbA1c) test every 3 months. Your doctor may also monitor your renal function, blood pressure, and cholesterol level.
The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.