Lorbrena Coupon & Prices

Your monthly Lorbrena cost savings if eligible

If you are eligible for the Lorbrena patient assistance program you can get your medication for free. Our monthly flat rate of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Lorbrena through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

Am I eligible for the Lorbrena patient assistance program?

You could receive your Lorbrena without paying the full retail price if you meet the eligibility criteria for assistance. This criteria is set by the pharmaceutical companies who are providing assistance programs. At NiceRx we review each application individually, although the main factors considered by most programs are:

• I am a permanent, legal resident of the United States or Puerto Rico
• I am uninsured or my insurance doesn’t cover my medication
• I meet certain income eligibility requirements

How do I apply for Lorbrena patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Lorbrena.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Lorbrena patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Lorbrena medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx a Lorbrena coupons provider?

At NiceRx, we help eligible individuals access the Lorbrena patient assistance program. This means that we are not a Lorbrena coupon, a Lorbrena discount card, or a Lorbrena copay card provider. We do not offer any medication trial offers, or free Lorbrena samples.

Can NiceRx help me get Lorbrena if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Lorbrena medication, or you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much is Lorbrena with insurance?

The cost of Lorbrena will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

How much does Lorbrena cost without insurance?

Lorbrena costs without insurance will vary depending on how much you buy and the retailer you buy it from. As a guide, Lorbrena tablets 25 mg will typically cost around $6,200 for 30 tablets. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

What is Lorbrena?

Lorbrena contains the active ingredient lorlatinib and is manufactured by Pfizer. It is FDA (U.S. Food and Drug Administration) approved for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC):

• That is caused by an abnormal anaplastic lymphoma kinase (ALK) gene
• That has spread to other parts of your body
• In patients that have already tried alectinib or ceritinib or who have taken both the medicine crizotinib and at least 1 other medicine, but their NSCLC is no longer responding to these treatments

ALK+ NSCLC spreads commonly to the brain. Treating brain metastases can be difficult as the medicine must cross the blood-brain barrier. The blood-brain barrier is a natural network that helps prevent harmful substances, like bacteria, from entering the brain. Lorbrena was designed to cross the blood-brain barrier and has been shown to shrink ALK+ NSCLC tumors that have spread to the brain.

Lorbrena active ingredients

Lorlatinib is an inhibitor that blocks enzymes in the body from working. Lorlatinib has been shown in clinical trials to work as an inhibitor against various mutant forms of the ALK enzyme. The efficacy of Lorbrena was demonstrated in a subgroup of patients with ALK-positive metastatic NSCLC (non-small cell lung cancer) who had previously been treated with one or more ALK kinase inhibitors. Lorlatinib results in antitumor activity. The overall antitumor effect of lorlatinib depends on the dose given.

Studies have assessed the overall response rate of tumors to treatment. This includes tumor reduction, throughout the body or within the brain. 76% of patients had their tumors shrink or disappear with Lorbrena.

Lorbrena should be taken exactly as prescribed by your doctor. The tablet should be swallowed whole. Do not crush, chew, or break it. Take the medicine at the same time each day, with or without food. If you do vomit after taking Lorbrena, do not take another dose. You must wait until your next dose is due, to take the medicine again. Do not stop or change your dose of Lorbrena without consulting your healthcare provider. The usual adult dose for non-small cell lung cancer is 100 mg orally once a day until either disease progression or unacceptable levels of toxicity occur.

Lorbrena side effects

The most common side effects or adverse events caused by Lorbrena include:

• Swelling in your arms, hands, legs, or feet (edema)
• Peripheral neuropathy – feeling numb, tingling, or burning pain in your hands or feet
• CNS effects (Central nervous system) – changes in mood
• Changes in mood
• Hyperglycemia (high blood sugar)
• Hypertriglyceridemia (high blood triglyceride levels)
• Hyperlipidemia (high blood cholesterol)
• Increased blood pressure leading to hypertension
• Tiredness
• Weight gain
• Joint pain
• Diarrhea

In rare instances, Lorbrena can cause more serious side effects or adverse reactions. These can include:

• Sudden chest pain, wheezing, dry cough, cough with mucus
• Difficulty breathing
• Fever
• Feeling light-headed, faint, or an abnormal heartbeat – your treatment may need to be stopped or you may need a pacemaker fitted
• Hallucinations
• Cognitive effects – problems with thought or memory

Your doctor will assess the benefits of using Lorbrena against your risk of side effects. Your doctor may discontinue or delay your treatment if you have certain side effects or adverse reactions.

Lorbrena drug interactions

Lorbrena can interact with other medications. These include:

• Antiviral treatments – atazanavir, boceprevir, nelfinavir, ritonavir
• Anticonvulsants for the treatment of seizures – carbamazepine, fosphenytoin
• Antibiotics for bacterial infection – clarithromycin, rifampin, telithromycin
• Corticosteroids – dexamethasone
• Antifungal treatments – fluconazole, itraconazole, ketoconazole
• Opioid pain killers – fentanyl, hydrocodone, methadone, oxycodone
• Strong CYP3A inducers – rifampin, phenytoin, phenobarbital
• CYP3A substrates – avanafil, everolimus, sirolimus, tacrolimus

This list is not exhaustive and other drugs may interact with Lorbrena.

Lorbrena contraindications

You should not use Lorbrena if you:

• Are allergic to the active ingredient lorlatinib
• Are allergic to any of the other ingredients in Lorbrena
• Are pregnant or are planning to become pregnant
• Are breastfeeding or are planning to breastfeed

Talk to your doctor before using Lorbrena if you:

• Are taking any of the medications that could interact with Lorbrena
• Have heart problems, such as AV block
• Hypertension (high blood pressure)
• Have lung disease, breathing problems
• Have liver disease
• Have kidney problems
• Have depression or suffer from seizures
• Have high blood cholesterol (hyperlipidemia)
• Have high blood triglycerides (hypertriglyceridemia)

Females who are able to become pregnant are advised to use effective non-hormonal birth control during treatment and for at least 6 months after the final dose. Birth control pills (oral contraceptives) and other hormonal birth control may not be as effective if used at the same time as Lorbrena. You should talk to your healthcare provider about the most appropriate birth control choices for you during this time. Males who have female partners who are able to become pregnant should use effective birth control during treatment and for at least 3 months after their final dose.

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