medicationsmavyretMavyret dosage

Mavyret Dosage, forms & strengths

Jamie Winn, PharmD
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Medically reviewed by  Jamie Winn, PharmD

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Mavyret (glecaprevir/pibrentasvir) is an HCV NS3/4A protease inhibitor that is manufactured by AbbVie Inc. It is FDA-approved to treat chronic hepatitis C virus infection (HCV) without cirrhosis or with compensated cirrhosis. It also indicated to treat HCV genotype 1 infection in patients who had previous hepatitis C treatment. Mavyret can be used in adults and children 3 years of age and older.

How does Mavyret work?

Mavyret has 2 medications that block the actions of 2 different proteins in the hepatitis C virus. Glecaprevir is an HCV NS3/4A protease inhibitor, which the virus needs for replication. Pibrentasvir prevents hepatitis C viral replication by blocking the HCV NS5A protein.

Mavyret dosage forms and strengths

  • Tablet: 100 mg of glecaprevir and 40 mg of pibrentasvir
  • Oral Pellets: 50 mg of glecaprevir and 20 mg of pibrentasvir

Mavyret dosage

The recommended dosage of Mavyret in adults and in pediatric patients 12 years of age and older, or in pediatric patients weighing at least 45kg is 3 tablets once a day with food for a total daily dose of glecaprevir 300mg and pibrentasvir 120mg.

The recommended dose for pediatric patients 3 years to less than 12 years old that weigh less than 45kg is as follows:

  • Less than 20kg: 150mg of glecaprevir and 60mg of pibrentasvir 60mg per day
  • 20kg to less than 30kg: 200mg of glecaprevir and 80mg of pibrentasvir per day
  • 30kg to less than 45kg: 250mg of glecaprevir and 100mg of pibrentasvir per day

The duration of therapy will be based on the genotype and whether you are a treatment-naïve or treatment-experienced patient.

Mavyret dosage restrictions

  • No dose adjustment of Mavyret is recommended in patients with mild, moderate, or severe renal impairment. This includes patients on dialysis.
  • No dose adjustment of Mavyret is recommended in patients with mild hepatic impairment (Child-Pugh A). Mavyret should be avoided in chronic HCV-infected patients with moderate or severe hepatic impairment (Child-Pugh B or Child-Pugh C) or those with a history of prior hepatic decompensation.

How to take Mavyret

  • Read the Full Prescribing Information, Drug Information, and Medication Guide that comes with this medication.
  • Take Mavyret exactly as your doctor prescribes it. Do not change your dose or stop taking this medication without discussing it with them first.
  • Mavyret is taken once a day with food. Your dose will be determined by your doctor based on your age and/or weight.
  • If you miss a dose and it is more than 18 hours from the time you usually take this medication, take the missed dose with food right away. If it is less than 18 hours, skip the missed dose and take your next dose at its regular time.

Mavyret dosage FAQs

What are some side effects of Mavyret?

Some common adverse reactions to Mavyret seen in clinical trials include:

  • Headache
  • Low red blood cells
  • Fatigue
  • Decreased appetite
  • Insomnia
  • Weakness
  • Skin rash
  • Depression

Mavyret can sometimes cause more serious side effects, including:

  • Severe allergic reactions (hives, swelling of the face or throat, and trouble breathing)
  • Increased risk of hepatitis B virus reactivation in HCV/HBV coinfected patients
  • Worsening liver disease

Contact your healthcare professional for medical advice about any side effects you experience while taking Mavyret. You can report your side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What are some drug interactions with Mavyret?

The concomitant use of Mavyret with other medications may change the way it works or increase the frequency and severity of side effects. You should ask your doctor if any of the prescription drugs, over-the-counter medications, vitamins, and herbal supplements you take may interact with Mavyret, including:

  • Carbamazepine
  • Efavirenz
  • St. John’s wort
  • Direct-acting antivirals such as ritonavir and darunavir
  • Ethinyl estradiol and other oral contraceptives
  • Atorvastatin
  • Simvastatin
  • Lovastatin
  • Pravastatin
  • Rosuvastatin
  • Cyclosporine
  • Digoxin
  • Dabigatran

Are there any contraindications or precautions with Mavyret?

You should not use Mavyret if you have an allergy to glecaprevir, pibrentasvir, or any inactive ingredients in its formulation. You should also avoid Mavyret if you have moderate to severe liver impairment or are currently taking Reyataz (atazanavir) or Rifadin (rifampin).

You should make sure your doctor is aware of your medical conditions including if you have an HBV infection, advanced liver disease, HIV infection, a previous liver or kidney transplant, or are pregnant, plan on becoming pregnant, or are breastfeeding.

Is it safe to use Mavyret while pregnant or breastfeeding?

It is not known what effects Mavyret may have on your unborn baby. Animal studies did not show any adverse effects. There is no data on whether this medication is excreted in breast milk or what effects it has on breastfed infants. You should always discuss the risks and benefits of any medication with your healthcare provider if you are pregnant, plan on becoming pregnant, or are breastfeeding.

What is the average price of Mavyret?

Mavyret is an extremely expensive medication. The average cost of #84 tablets of Mavyret 100mg/40mg is over $20,000.

Who should not take Mavyret?

You should not take Mavyret if you are allergic to glecaprevir/pibrentasvir or any other ingredients in this medication. You should also not take this medication if you are currently being treated with atazanavir or rifampin.

Can your hepatitis C infection come back after finishing Mavyret treatment?

Sometimes your HCV infection will return after stopping your HCV treatment. Your doctor will run tests 3 months post-treatment to check for reinfection. Mavyret can cure your current HCV infection but it cannot prevent future infections.

How long will you have to take Mavyret?

Your treatment duration of Mavyret will be 8 to 16 weeks, depending on the HCV genotype and your prior treatment experience.

How should you store Mavyret tablets?

Store Mavyret in its original package below 86°F (30°C) until you are ready to take it.

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.