Premarin Coupon & Prices

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Medically reviewed by  Jamie Winn, PharmD

Your monthly Premarin cost savings if eligible

If you are eligible for the Premarin patient assistance program you can get your medication for free. Our monthly flat rate of $49 per medication covers the cost of our services in applying for the program and requesting your ongoing refills on your behalf. If you obtain your Premarin through NiceRx, you will only pay $49 a month regardless of the retail price of your medication.

StrengthAvg. monthly price at
a US pharmacy
NiceRx monthly
Monthly savings
with NiceRx
0.3mg 28 tablets$225.00$49.00$176.00
0.45mg 28 tablets$225.00$49.00$176.00
0.625mg 28 tablets$225.00$49.00$176.00
0.9mg 28 tablets$225.00$49.00$176.00
1.25mg 28 tablets$225.00$49.00$176.00

Am I eligible for the Premarin patient assistance program?

You could receive your Premarin without paying the full retail price if you meet the eligibility criteria for assistance. This criteria is set by the pharmaceutical companies who are providing assistance programs. At NiceRx we review each application individually, although the main factors considered by most programs are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for Premarin patient assistance?

We do everything that we can to take the hassle and stress out of applying for patient assistance programs. Simply start by filling in our enrollment application. We will ask for details about your healthcare provider, your insurance, and your household income. This information is required by the pharmaceutical companies you are applying to for assistance. We may also be able to help you access patient assistance for other medications that you have been prescribed, so be sure to tell us about any medications you are taking as well as Premarin.

NiceRx will review the information you have provided, and if we determine that you may be eligible for assistance, we will seek to enroll you in the Premarin patient assistance program. We will handle the enrollment process for you by working with your healthcare provider and preparing all the required paperwork for your doctor to sign. We will also request your Premarin medication refills on your behalf for up to 1 year once you are enrolled in the program.

Is NiceRx a Premarin coupons provider?

At NiceRx, we help eligible individuals access the Premarin patient assistance program. This means that we are not a Premarin coupon, a Premarin discount card, or a Premarin copay card provider. We do not offer any medication trial offers or free Premarin samples.

Can NiceRx help me get Premarin if I have insurance?

We may be able to help you if you have insurance, including if your insurance company will not pay for your Premarin medication, or you have a high copay or coinsurance responsibility. We may even be able to assist if you do not have insurance. Please fill in our enrollment application to find out more.

How much is Premarin with insurance?

The cost of Premarin will vary in line with the specific terms of your healthcare plan. For further details about what you may need to pay, your insurance provider or pharmacist will be able to calculate the copay costs with your current insurance.

How much does Premarin cost without insurance?

Premarin costs without insurance will vary depending on the number of tablets and the retailer you buy it from. As a guide, Premarin oral tablets will typically cost around $657 for 100 tablets. If you obtain your medication through NiceRx, you will pay a flat monthly rate of $49 per medication regardless of its retail price.

What is Premarin?

Premarin (conjugated estrogen) tablets contain a mixture of conjugated estrogens (female hormones). It is a mixture of sodium estrone sulfate and sodium equilin sulfate. Tablets are available in strengths of 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, and 1.25 mg of conjugated estrogens.

Premarin is used by women to reduce symptoms of menopause such as hot flushes, night sweats, difficulty sleeping, low mood or anxiety, and vaginal dryness. Estrogen is also used in the prevention of postmenopausal osteoporosis.

Premarin active ingredients

Estrogens are normally produced by the ovarian follicle in adult women and are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Estradiol is the primary human estrogen.

After menopause, most estrogen is produced in the body by conversion of androstenedione (released from the adrenal cortex), into estrone. Estrone and the sulfate-conjugated form estrone sulfate and are the main estrogens in postmenopausal women.

Estrogens bind to proteins within cells in estrogen-responsive tissues.

Estrogens control the secretion of gonadotropins, through a negative feedback mechanism, reducing the elevated levels of these gonadotropins in postmenopausal women.

Premarin side effects

The most common side effects caused by Premarin include:

  • Nausea – feeling sick
  • Stomach pain, gas
  • Back pain
  • Headache
  • Depression
  • Sleep disturbance
  • Breast pain
  • Changes in menstrual periods
  • Vaginal itching or discharge

In rare instances, Premarin can cause more serious side effects. These include:

  • Symptoms of a heart attack – pain or pressure in the chest spreading to your jaw or shoulder, feeling sick, and sweating
  • Symptoms of a stroke – feeling numb or weak (especially down one side of the body), sudden severe headache, slurred speech, problems with vision or balance
  • Symptoms of a blood clot – sudden vision loss, sharp chest pain, shortness of breath, pain or warmth in one or both legs
  • Tender or swollen stomach
  • Jaundice (yellow skin or eyes)
  • Confusion or unusual behavior
  • Unexplained vaginal bleeding
  • Pelvic pain
  • A lump in your breast
  • Symptoms of an increase in calcium blood level – nausea, vomiting, constipation, increased thirst or urinating, muscle weakness, bone pain, or lack of energy

Your doctor will assess the benefits of taking Premarin against your risk of side effects.

Premarin drug interactions

Premarin can interact with other medications. Tell your prescribing doctor about all drugs you are taking, including vitamins, herbal and dietary supplements, particularly:

  • Dantrolene – muscle relaxant
  • Hemin – for the treatment of porphyria
  • Lenalidomide, pomalidomide, thalidomide, carfizomib – for the treatment of cancer
  • Tranexamic acid – Antifibrinolytic (helps blood to clot)

This list is not exhaustive and other drugs may interact with Premarin

Premarin warning and precautions

Premarin is not suitable for everyone. Do not take Premarin if you:

  • Are allergic to conjugated estrogens
  • Are allergic to any of the other ingredients in Premarin (you can find these listed in the leaflet which comes with the medication)
  • Have unusual vaginal bleeding that has not been checked by a doctor
  • Have liver disease
  • Have a history of heart attack, stroke, or blood clots
  • Have a history of hormone-related cancer
  • Have cancer of the breast, uterus, cervix, or vagina
  • Are pregnant or planning to become pregnant

Talk to your doctor before taking Premarin if you:

  • Are taking any of the medications that could interact with Premarin
  • Have heart disease
  • Have liver problems, or jaundice caused by pregnancy or taking hormones
  • Have kidney disease
  • Have gallbladder disease
  • Have asthma
  • Have epilepsy or any other seizure disorder
  • Suffer from migraines
  • Have lupus
  • Have had a hysterectomy
  • Have endometriosis or uterine fibroid tumors
  • Have porphyria
  • Have a thyroid disorder
  • Have high levels of calcium in your blood
  • Are breastfeeding or are planning to breastfeed

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The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.