Home / Medications / Vagifem

Vagifem Patient assistance program

Is your Vagifem medication too expensive? Through NiceRx, you may be able to get Vagifem for only $49 per month.*

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Vagifem medication.

Get started today
  • Secure: Your personal and medical information is safe with us
  • Convenient: We manage the whole process and we’re here to assist you
  • Ongoing refills: We request your medication refills on your behalf
  • Secure: Your personal and medical information is safe with us
  • Convenient: We manage the whole process and we’re here to assist you
  • Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

  • Apply Online

    Get started by filling out the online enrollment form to find out if you are eligible.

  • Qualify

    NiceRx verifies your eligibility for medication assistance and instantly notifies you if you are qualified.

  • Receive Medication

    We handle the entire ordering process including requesting your ongoing refills once accepted.

An introduction to NiceRx

Play video (1:52)

Your monthly Vagifem cost savings if eligible

The Vagifem patient assistance program can provide your medication for free. We simply charge $49 a month per medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Vagifem, regardless of the retail price.

Am I eligible for the Vagifem patient assistance program?

To find out if you are eligible for Vagifem assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Vagifem patient assistance program?

Our application process aims to make it as easy as possible to apply for the Vagifem patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Vagifem.

NiceRx will review your application and determine whether you may be eligible for Vagifem assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Vagifem patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Vagifem.

Is NiceRx a Vagifem coupons provider?

NiceRx is a service provider that helps eligible individuals access the Vagifem patient assistance program. We do not offer trial offers or free Vagifem samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Vagifem coupons, discount cards, or Vagifem copay cards.

Can NiceRx help me get Vagifem if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Vagifem medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more. 

How much is Vagifem with insurance?

The cost of Vagifem will vary by the terms of your healthcare plan. To find out what you might need to pay for Vagifem with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

How much does Vagifem cost without insurance?

Vagifem prices without insurance will vary by retailer. As a guide, a Vagifem applicator with 8, 10 mcg Vagifem tablets typically costs around $200. 

What is Vagifem?

Vagifem is a prescription medication given to women who have been through the menopause. It’s used to treat vaginal changes called vaginal atrophy. The medication is a hormone replacement therapy that increases the amount of estrogen in and around your vagina, helping to ease and reverse your symptoms. 

Vagifem comes as a tablet that you insert into your vagina using the applicator that comes with your medication. You typically insert a Vagifem tablet once a day for the first two weeks, then one tablet twice a week for between three to six months. Your prescribing doctor will tell you how much Vagifem to take and for how long, based on your condition and medical history. Always take your Vagifem exactly as directed. 

Vagifem active ingredients

The active ingredient in Vagifem is called estradiol. This is a type of estrogen that’s found naturally in your body. Vagifem is a hormone replacement therapy (HRT). The estradiol it contains adds to the estradiol already in your body (replacing the hormone you lost after the menopause) and has the same effect on your body.

Vagifem side effects

The most common side effects caused by Vagifem include:

  • Headaches
  • Breast pain
  • Bloating
  • Stomach or abdominal cramps
  • Feeling sick (nausea)
  • Vomiting (being sick)
  • Fluid retention
  • Vaginal yeast infections
  • Irregular vaginal bleeding or spotting
  • Hair loss

In rare instances, Vagifem can cause more serious side effects. When these occur, they may include:

  • Severe allergic reactions to the medication 
  • An increased risk of blood clots that can cause heart attacks and strokes
  • An increased risk of breast and ovarian cancer, and cancer of the lining of the uterus (womb)
  • Enlargement of non-cancerous tumors of the uterus called fibroids
  • Dementia, particularly in women aged 65 and older
  • Liver problems
  • Gallbladder disease
  • High blood pressure (hypertension)
  • High blood sugar (diabetes) 

Your doctor will assess the benefits of taking Vagifem against your risk of side effects.

Vagifem drug interactions

Vagifem can interact with other medications. This can change how Vagifem and the other medications work and can make some side effects more likely. These medications include:

  • Any other hormone therapy medications
  • Any antiviral medications taken to treat an HIV infection, including ritonavir, atazanavir, indinavir, saquinavir, or nelfinavir
  • Any antiviral medications take to treat a hepatitis C infection, including boceprevir or telaprevir
  • Any other antiviral medications taken to treat another viral infection 
  • Any antibiotics taken to treat a bacterial infection, including rifampicin, clarithromycin, or telithromycin
  • Any antifungal medications taken to treat a fungal infection, including ketoconazole and itraconazole
  • Any medications taken to lower cholesterol levels, including atorvastatin or rosuvastatin
  • Any anticonvulsant medications taken to reduce the chances of you having seizures, like carbamazepine, phenobarbital, or phenytoin
  • A herbal supplement called St John’s-wort (Hypericum perforatum)

If you don’t know whether you’re taking any of these, take the packaging of all your medications and supplements to your doctor or pharmacist.

Vagifem warning and precautions

Don’t take Vagifem if you:

  • Are allergic to the active ingredient estradiol or any of the other ingredients in Vagifem 
  • Have, or have ever had, breast cancer, ovarian cancer, or cancer of the uterus (womb)
  • Have ever had a stroke or heart attack
  • Have, or have had, a blood clot
  • Have, or have had, any liver problems
  • Have ever been diagnosed as having a bleeding disorder
  • Currently have unusual vaginal bleeding – this can be a warning sign of cancer of the uterus (womb)
  • Think you may be pregnant
  • Are not a woman who has been through the menopause

Talk to your doctor before taking Vagifem if you:

  • Are taking any of the medications that could interact with Vagifem 
  • Have recently had any unusual vaginal bleeding
  • Are due to have surgery or any form of bed rest
  • Are breastfeeding or are planning to breastfeed

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking down the different programs and filling out all the required paperwork for each program.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

COVID-19 Message

Due to the Coronavirus (COVID-19), please be aware that customer service response times may be longer than expected. If you are unable to reach us by phone due to increased call volumes, please fill out this contact form. We have taken steps to ensure that we remain open during these challenging times and are working hard to ensure that your inquiries are answered as soon as possible.