- Type 2 diabetes
$49 per month
- Type 2 diabetes
$49 per month
Most common
More serious
Most common
More serious
You should not use Rybelsus if you:
You should talk to your doctor before using Rybelsus if you:
You should not use Ozempic if you:
You should talk to your doctor before using Ozempic if you:
Once daily
0.25mg once weekly
0.5mg once weekly
1mg once weekly
30, 3 mg Rybelsus oral tablet will cost around $950
2 mg/1.5 ml pre-filled Ozempic Pen costs $899 on average for 1.5 milliliters
Rybelsus and Ozempic are brand names of semaglutide, a glucagon-like peptide-1 receptor agonist used for diabetes treatment. Rybelsus is an oral tablet and Ozempic is an injection and both are FDA (U.S. Food and Drug Administration) approved drugs.
If you have Type 2 diabetes and metformin is not achieving glycemic control, your healthcare professional may prescribe either Rybelsus or Ozempic. In clinical trials, both Rybelsus and Ozempic were effective at treating Type 2 diabetes and lowering blood sugar levels but Ozempic has shown to reduce cardiovascular events, unlike Rybelsus.
Both drugs contain the same active ingredient. Read on to find out about their similarities and differences.
Rybelsus is a diabetes medication manufactured by Novo Nordisk. It is given to adults with Type 2 diabetes to help lower blood sugar (glucose) when used with exercise and changes in diet.
Rybelsus is a non-insulin medication that causes your pancreas to produce more insulin, helping to lower your blood glucose levels.
Rybelsus is taken in tablet form, usually once a day when you first wake up. Make sure you always use your Rybelsus as directed by your doctor or pharmacist.
Ozempic is a diabetes medication given to adults with Type 2 diabetes to:
Ozempic can help you lower your blood sugar levels when used alongside dietary and lifestyle changes. It causes you to secrete more insulin, helping to lower your blood sugar and reduce your risk of major cardiovascular events, like heart attacks and strokes, if you have heart disease.
Ozempic is taken as a weekly injection. It is injected under your skin (subcutaneous injection), using a pre-filled pen. As it is a non-insulin medication, your doctor may prescribe Ozempic alongside insulin. Make sure you always use your Ozempic as directed by your doctor.
The active ingredient in Rybelsus and Ozempic is called semaglutide. It is a non-insulin drug that can help lower your blood glucose levels by stimulating the cells in your pancreas that produce insulin (called beta cells).
When you take Rybelsus or Ozempic, semaglutide molecules attach to beta cells in your pancreas at sites called glucagon-like peptide-1 (GLP-1) receptors. The semaglutide stimulates these receptors, which makes the beta cells produce more insulin, helping to lower your blood sugar after you’ve eaten.
Semaglutide also encourages the growth of more beta cells in your pancreas, allowing your pancreas to produce higher levels of insulin, reversing any declines in your body’s insulin production.
Other common brands of GLP-1 agonists are Trulicity (dulaglutide), Byetta (exenatide), Bydureon Bcise (exenatide extended-release), and Victoza (liraglutide).
The prescribing information for both drugs recommends the following dosing:
Rybelsus is an oral medication normally started with 3 mg once daily for 30 days. After 30 days on the 3 mg dose, increase the dose to 7 mg once daily. The dose may be increased to 14 mg once daily if additional glycemic control is needed after at least 30 days on the 7 mg dose. Rybelsus should be taken on an empty stomach.
Ozempic is normally started with 0.25 mg once weekly. After 4 weeks, the dose may increase to 0.5 mg once weekly. If after at least 4 weeks additional glycemic control is needed, an increase to 1 mg once weekly may be given. Ozempic is to be taken once weekly at any time of day, with or without meals.
The maximum dose available of injected Ozempic is 1mg whereas the maximum dose of Rybelsus is 14mg. This difference in doses suggests that a lot of Rybelsus is still broken down in the gut before being absorbed.
The most common side effects of Rybelsus include:
For some people, Rybelsus and Ozempic can cause more serious side effects. These are rarer but can include:
RELATED: Rybelsus side effects, Ozempic side effects
Tell your prescribing physician if you take any of the following as they can interact with Rybelsus and Ozempic:
Always speak to your healthcare provider for medical advice regarding drug interactions, taking supplements, over-the-counter medications, and drinking alcohol when using Rybelsus or Ozempic. Healthcare professionals are the most reliable and accurate source of drug information.
Don’t take Rybelsus or Ozempic if you:
Talk to your doctor before taking Rybelsus or Ozempic if you:
It is possible that you may lose body weight while taking Rybelsus or Ozempic, however, the medication isn’t intended to be used for weight loss.