Latuda Dosage, forms & strengths
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Latuda is a prescription drug containing lurasidone hydrochloride as the active ingredient. It is FDA (U.S. Food and Drug Administration) approved for the treatment of schizophrenia and major depressive episodes in people with Bipolar I Disorder. It can be used in adults, adolescents, and/or children 10 years of age or older.
Latuda forms and strengths
Latuda is available as oral tablets in various strengths:
- Tablet: 20mg, 40mg, 60mg 80mg, and 120mg
Latuda is an atypical antipsychotic that works by blocking serotonin and dopamine receptors in your brain. It is approved to treat schizophrenia in adults and adolescents aged 13 to 17 years and bipolar depression in adults and pediatric patients (10 to 17 years) as monotherapy. It is also used in adult patients with bipolar depression as adjunctive therapy along with lithium or valproate.
The recommended starting dose for adults taking Latuda is 40mg per day. It has been shown to be effective in a dose range from 40mg per day to a maximum of 160 mg per day. Your dosage will depend on a number of factors including your medical condition, age, and other medications you are taking.
Latuda adult dosage chart
|Indication||Starting dosage||Standard dosage||Maximum dosage|
|Schizophrenia||40mg taken once daily with food.||40mg to 160mg taken once daily with food.||160mg per day|
|Bipolar depression||20mg taken once daily with food.||20mg to 120mg taken once daily with food.||120mg per day|
Latuda pediatric dosage chart
|Indication||Age||Starting dosage||Standard dosage||Maximum dosage|
|Schizophrenia||13 to 17 years||40mg once daily with food.||40mg to 80mg once daily with food.||80mg per day|
|Bipolar depression||10 to 17 years||20mg once daily with food.||20mg to 80mg once daily with food.||80mg per day|
Latuda dosage restrictions
- Mild renal impairment (CrCl ≥50 mL/min) requires no dosage adjustment.
- Moderate-to-severe renal impairment (CrCl <50 mL/min) should start at 20 mg/day initially and not exceed 80 mg/day.
- Mild hepatic impairment (Child-Pugh class A) requires no dosage adjustment.
- Moderate hepatic impairment (Child-Pugh class B [Score 7-9]) should have a starting dose of 20 mg/day and not exceed 80 mg/day.
- Severe hepatic impairment (Child-Pugh class C [Score 10-15]) should start at 20 mg/day and not exceed 40 mg/day.
- Coadministration with strong CYP3A4 inhibitors such as ketoconazole is contraindicated.
- Coadministration with moderate CYP3A4 inhibitors such as diltiazem and verapamil requires the Latuda dose to be reduced to half of the original level.
- Coadministration with strong CYP3A4 inducers such as rifampin and carbamazepine is contraindicated.
- Coadministration with moderate CYP3A4 inducers such as modafinil requires an increase in the dose of Latuda.
- There is no dosage adjustment necessary if Latuda is taken with lithium or valproate.
How to take Latuda
- Take Latuda as prescribed by your healthcare professional. Do not exceed the prescribed dose of medication. Your healthcare provider may decide to change your dose several times until the most effective dose is determined.
- Latuda should come with prescribing information and a Medication Guide. Please review this information carefully before taking the medication.
- Take Latuda by mouth with food.
- If you miss a dose of Latuda, take it as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not double your next dose or take more than what is prescribed to make up for a missed dose.
- If you take too much Latuda, call your healthcare professional or poison control center or go to the nearest hospital emergency room right away.
- Avoid eating grapefruit or drinking grapefruit juice while taking Latuda. It may affect the amount of Latuda in your blood.
- Do not drive or operate heavy machinery until you know how Latuda affects you.
- Do not become too hot or dehydrated while taking Latuda.
- Store Latuda tablets at room temperature between 68°F to 77°F (20°C to 25°C) away from heat, moisture, and direct light.
- Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Latuda dosage FAQs
How long does it take for Latuda to work?
While you may see some improvements in your symptoms in the first 1 or 2 weeks, it can take up to 6 weeks to see Latuda’s full effect.
How long does Latuda stay in the system?
Latuda has a half-life of 18 hours so it will take 4 to 6 days to completely clear the body.
What happens if I miss a dose of Latuda?
If you miss a dose of Latuda, take it as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not double your next dose or take more than what is prescribed to make up for a missed dose.
Which medications interact with Latuda?
Since Latuda is mainly metabolized by the liver, any medication that strongly inhibits hepatic enzyme CYP3A4 metabolism (ketoconazole, clarithromycin, ritonavir) or speeds up its metabolism (rifampin St. John’s wort, phenytoin, carbamazepine) should be avoided. Some other drug interactions that may occur with Latuda include:
What happens when mixing alcohol with Latuda?
Avoid drinking alcohol or using illegal drugs while you are on Latuda. They may worsen your symptoms and increase the adverse effects of this medication.
Is it safe to use Latuda while pregnant or breastfeeding?
Antipsychotic use during the third trimester of pregnancy has a risk for extrapyramidal symptoms (abnormal muscle movements) and/or withdrawal symptoms in newborns following delivery. The newborn can experience symptoms such as agitation, stiff muscles, respiratory distress, somnolence, and tremor. These complications can vary in severity, with some being self-limited and others requiring ICU support and prolonged hospitalization.
What are some side effects of Latuda?
Some common side effects of Latuda include:
- Increased blood sugar
- Weight gain
- Muscle stiffness
- Orthostatic hypotension
- Increased prolactin levels (hyperprolactinemia)
Some serious side effects that Latuda may cause include:
- Increased risk of death in elderly patients treated for dementia-related psychosis.
- Increased risk of suicidal thoughts or behavior, especially in children and young adults. Any patient on antidepressant or antipsychotic drugs should be monitored for clinical worsening or emergence of suicidal thoughts and behaviors.
- Allergic reactions
- Worsening manic episodes
- Low white blood cell counts
- Tardive dyskinesia, which are involuntary movements that may include facial grimacing, sticking out the tongue, and blinking rapidly.
- Neuroleptic malignant syndrome, whose symptoms include fever, confusion, abnormal heartbeats, rigid or stiff muscles, and hallucinations.
Make sure to call your healthcare professional for medical advice about adverse reactions.
What labs or tests will be performed while I’m taking Latuda?
Laboratory and/or medical tests (such as blood glucose, complete blood count, blood pressure, weight, and cholesterol/triglyceride levels) may be performed periodically to monitor your progress or check for side effects.