What is Mydayis Uses, warnings & interactions
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Mydayis (amphetamine/dextroamphetamine) is a central nervous system (CNS) stimulant that is manufactured by Shire, LLC. It was approved in 2001 by the U.S. Food and Drug Administration (FDA) to treat symptoms of attention deficit hyperactivity disorder (ADHD). The combination of amphetamine and dextroamphetamine is also sometimes used to treat narcolepsy.
What is Mydayis used for?
Mydayis (amphetamine/dextroamphetamine) is a long-acting stimulant medication whose active ingredients consist of mixed amphetamine salts. It is approved by the U.S. Food and Drug Administration (FDA) to treat:
- Attention Deficit Hyperactivity Disorder (ADHD) in patients 13 years and older.
How does Mydayis work?
Amphetamine products such as Mydayis are non-catecholamine sympathomimetic amines that work in the treatment of ADHD by increasing the release of the neurotransmitters dopamine and norepinephrine in your brain. The increase of these chemicals in the brain is thought to help increase your ability to pay attention, stay focused, and control your impulsivity and hyperactive behaviors.
Amphetamines also trigger the release of epinephrine, serotonin, and histamine. It is not known if this contributes to relieving symptoms of ADHD.
What are the most commonly prescribed doses of Mydayis?
- 12.5mg extended-release capsule
- 25mg extended-release capsule
- 37.5mg extended-release capsule
- 50mg extended-release capsule
Before taking Mydayis
Before starting Mydayis, tell your healthcare provider if you have any of the following medical conditions:
- Heart problems including defects or hypertension (high blood pressure)
- Personal or family history of mental illness, including bipolar disorder, psychosis, depression, or suicidal thoughts or behaviors
- Raynaud’s phenomenon (circulation problems in your fingers or toes)
- History of seizures
- Kidney disease
- Thyroid disease
- Are pregnant, plan on becoming pregnant, or are breastfeeding
How to take Mydayis
- Read the Full Prescribing Information, Instructions for Use, and Medication Guide that comes with your Mydayis.
- Take Mydayis exactly as your healthcare provider prescribes it to you. Do not change your dose or stop taking Mydayis without discussing it with them.
- Mydayis is typically taken once daily in the morning right after waking up. You can take Mydayis with or without food but should take it the same way each time.
- You should swallow the Mydayis capsules whole. If you have difficulties swallowing, you can open up the capsule and sprinkle it over a spoonful of applesauce. The mixture should then be swallowed immediately without chewing. Do not store the Mydayis and applesauce mixture for later use.
- If you miss a dose of Mydayis, skip the missed dose and take your dose the next morning at your regular time. Do not take Mydayis later in the day to make up for a missed dose.
- Your doctor may periodically stop your Mydayis treatment to check your ADHD symptoms.
- If you think you or your child has taken too much Mydayis, contact your doctor or go to the nearest emergency room immediately. Symptoms of too much Mydayis include restlessness, tics (muscle twitches), rapid breathing, confusion, hallucinations, and muscle weakness.
Mydayis is contraindicated in patients who have any of the following medical conditions:
- Known hypersensitivity to amphetamine formulations, or any other ingredients in Mydayis.
- Use of a monoamine oxidase inhibitor (MAOI) within the previous 14 days.
- Sudden death has occurred with the use of CNS stimulants such as Mydayis in pediatric patients with structural heart defects or other serious heart problems. Stroke, heart attack, and sudden death have also been reported in adults. Mydayis should be avoided in patients with structural heart abnormalities and other serious heart problems.
- Mydayis can cause an increase in blood pressure and heart rate so you should monitor your BP and pulse.
- Mydayis use can cause mental health issues such as psychosis or manic symptoms, even in patients with no prior history.
- Pediatric patients should have their height and weight monitored during treatment as Mydayis may cause long-term growth suppression.
- Mydayis may cause circulation problems, especially in the fingers and toes. You should be monitored for any changes in circulation.
- Mydayis may lower the seizure threshold and should be discontinued if a seizure occurs.
- There is an increased risk of serotonin syndrome with Mydayis, especially if taken with other serotonergic drugs such as SSRIs and SNRIs. If this occurs, Mydayis should be discontinued and you should seek immediate medical assistance.
- Mydayis use has a high potential for abuse and dependence. Your risk should be assessed prior to starting treatment and then monitored while taking Mydayis.
- If you suddenly stop using Mydayis, you can have withdrawal symptoms. Notify your doctor immediately if you experience symptoms such as extreme fatigue, headache, anxiety, depression
Most common side effects of Mydayis
The most common possible side effects (incidence ≥5% and at a rate at least twice placebo) of Mydayis include:
- Trouble sleeping
- Loss of appetite
- Weight loss
- Dry mouth
- Increased heart rate
- Increased blood pressure
Mydayis can cause serious side effects including:
- Life-threatening allergic reactions including angioedema, and trouble breathing
- Serious heart problems such as chest pain and shortness of breath
- Numb, cold, or pale fingers and toes
Contact your healthcare provider for medical advice about any adverse effects you experience while taking Mydayis. You can report your side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Mydayis drug interactions
When Mydayis is taken with other drugs, it may change the way they work and may increase the frequency and severity of side effects. Make sure your doctor is aware of all prescription drugs, over-the-counter medications, vitamins, and herbal supplements you take, including:
- Antidepressants such as SSRIs (paroxetine), SNRIs, and MAOIs (tranylcypromine)
- Omeprazole, esomeprazole, cimetidine, and other stomach medicines
- Migraine medications such as triptans
- St. John’s wort
There are other ADHD medications that your healthcare professional can prescribe if Mydayis is not the right medication for you. Some alternative FDA-approved treatment options include:
- Adderall XR (amphetamine/dextroamphetamine)
- Vyvanse (lisdexamfetamine)
- Ritalin (methylphenidate)
- Desoxyn (methamphetamine)
- Xelstrym (dextroamphetamine)
How does Mydayis compare with Vyvanse (lisdexamfetamine)?
Vyvanse and Mydayis are both extended-release medications taken once a day to treat ADHD in adults. They are both FDA-approved for ADHD treatment in children; Mydayis for adolescents 13 years of age and older and Vyvanse for children 6 years of age and older.
While Vyvanse only contains 1 active ingredient, Mydayis is a combination of 4 ingredients. Because of how Vyvanse needs to be metabolized to work, its abuse potential is less than Mydayis. It also has fewer drug interactions. Mydayis and Vyvanse have not been compared directly in clinical studies but individual studies have shown them both to be effective in treating ADHD in adults and children.
There is currently no generic alternative available for either medication. Mydayis has an average cost of around $400 for #30, 50mg capsules while Vyvanse costs over $400 for #30, 30mg capsules.
How long does Mydayis stay in your system?
The amphetamine salts of Mydayis have a half-life of between 10 to 13 hours and will stay in your bloodstream for around 3 days.
How do I store Mydayis?
You should store Mydayis in a tight, light-resistant container at room temperature between 15ºC to 30ºC (59ºF to 86ºF).
Will I become addicted to Mydayis?
Amphetamine products such as Mydayis have a high chance of abuse and can cause physical and psychological dependence. Your doctor should monitor you or your child for signs of abuse and dependence before and during Mydayis treatment.
How long does it take for Mydayis to start working?
Mydayis starts working about two hours after taking a dose and can last up to 16 hours.
Can you take Mydayis while you are pregnant or breastfeeding?
There is limited data on the use of amphetamine salts during pregnancy but based on animal studies may cause fetal harm. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Mydayis during pregnancy. You can register online through the National Pregnancy Registry for Psychiatric Medications or by calling 1-866-961-2388.
Amphetamines are found in breast milk and based on the potential for adverse reactions, Mydayis use during lactation is not recommended. You should always discuss the risks and benefits of any medication with your healthcare provider if you are pregnant, plan on becoming pregnant, or are breastfeeding.
Should I take Mydayis in the morning or at night?
Mydayis should be administered once daily in the morning immediately after waking up. It can last up to 16 hours and cause difficulty sleeping.
Is there a generic for Mydayis?
Currently, there is no generic for Mydayis available on the market. However, you can still save on brand-name drugs like Mydayis through NiceRx if eligible for assistance.