Nerlynx Coupon & Prices

Is your Nerlynx medication too expensive? Start receiving your medication for only $49 per month.*

Complete a free online enrollment application to find out if you’re eligible to pay only $49 per month for your Nerlynx medication with our help.

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  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf
  • NiceRx Benefit
    Secure: Your personal and medical information is safe with us
  • NiceRx Benefit
    Convenient: We manage the whole process and we’re here to assist you
  • NiceRx Benefit
    Ongoing refills: We request your medication refills on your behalf

NiceRx works with your healthcare provider to help you access affordable medications directly from U.S. pharmaceutical companies.

How it works

  • Enroll online

    Get started by filling out the online enrollment application to find out if you are eligible for assistance.

  • Pre-qualification

    NiceRx verifies your eligibility for medication assistance and notifies you if you are pre-qualified. The pharmaceutical company provides your medication for free, and you only pay our service fee.

  • Submit documents

    We will request documents to be submitted by you and your healthcare provider that are required by the pharmaceutical company to complete your enrollment.

  • Receive medication

    Once approved, the pharmaceutical company typically ships a 90-day supply of medication to your home or healthcare provider’s address. Final acceptance is determined by the pharmaceutical company.

Medically reviewed by  Jamie Winn, PharmD

Your monthly Nerlynx cost savings if eligible

The Nerlynx patient assistance program can provide your medication for free. We simply charge $49 per month for each medication to cover the cost of our services. With NiceRx, you will only pay $49 to obtain your Nerlynx, regardless of the retail price.

Am I eligible for the Nerlynx patient assistance program?

To find out if you are eligible for Nerlynx assistance you can apply online using our enrollment application. Each pharmaceutical company sets its eligibility criteria, and we will review your application individually to determine if you may be eligible. The three main factors to consider are:

  • I am a permanent, legal resident of the United States or Puerto Rico
  • I am uninsured or my insurance doesn’t cover my medication
  • I meet certain income eligibility requirements

How do I apply for the Nerlynx patient assistance program?

Our application process aims to make it as easy as possible to apply for the Nerlynx patient assistance program. The first step is to complete our online enrollment application. We will ask you for details about your healthcare provider, your insurance plan, and your household income as this information is required by the pharmaceutical companies. We may be able to help you apply for other patient assistance programs too, so be sure to tell us about any medications you are taking as well as Nerlynx.

NiceRx will review your application and determine whether you may be eligible for Nerlynx assistance. If so, we will handle the full enrollment process for you and prepare all required documents for your healthcare provider to sign. Once you are successfully enrolled in the Nerlynx patient assistance program, we will help you manage your prescription refills by requesting refills on your behalf throughout your enrollment period. At the end of your enrollment period, we will contact you for updated information and seek to re-enroll you so you can continue to access affordable Nerlynx.

Is NiceRx a Nerlynx coupons provider?

NiceRx is a service provider that helps eligible individuals access the Nerlynx patient assistance program. We do not offer trial offers or free Nerlynx samples. When obtaining your medication through NiceRx, you will only pay $49 a month per medication. This will likely save you more money than if you were to use Nerlynx coupons, discount cards, or Nerlynx copay cards.

Can NiceRx help me get Nerlynx if I have insurance?

NiceRx may be able to help you if your insurance company will not pay for your Nerlynx medication. We may also be able to help if you have a high copay or coinsurance responsibility. Whether you have insurance or not, apply online using our enrollment application to find out more.

How much does Nerlynx cost without insurance?

Nerlynx prices without insurance will vary depending on how much you buy. Prices will also vary by retailer. As a guide, Nerlynx oral tablets 40 mg typically cost $14,200 for 133 tablets.

How much does Nerlynx cost with insurance?

The copay for Nerlynx will vary by the terms of your healthcare plan. To find out what you might need to pay for Nerlynx with insurance, your insurance provider or pharmacist will be able to help you calculate the copay costs with your current insurance.

What is Nerlynx?

Nerlynx is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Puma Biotechnology, Inc. Nerlynx is a tyrosine kinase inhibitor used in combination with capecitabine for the extended adjuvant treatment of adult patients with early-stage HER2-positive breast cancer, to follow adjuvant trastuzumab-based therapy.

What doses of Nerlynx are available?

Nerlynx is available in tablet form, in the following doses: 40 mg.

For antidiarrheal prophylaxis start loperamide with the first dose of Nerlynx and continue during the first 2 cycles (56 days) of treatment. Patients are advised to maintain 1-2 bowel movements per day and how to use antidiarrheal treatment regimens.

The recommended dose for Nerlynx use is 240 mg (6 tablets) given orally once daily with food, continuously for one year. Interruptions of dose and/or reductions of dose are recommended based on individual safety and tolerability. Reduce the starting dose to 80 mg in patients with severe hepatic impairment.

Please see the full prescribing information for additional safety information and always speak with your healthcare provider about any changes to your dose so they can monitor and evaluate your condition.

Nerlynx active ingredients

Neratinib is an intracellular kinase inhibitor that irreversibly binds to epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and HER4.

Neratinibs mechanism of action is to reduce EGFR and HER2 autophosphorylation, MAPK, and AKT signaling pathways and shows antitumor activity in EGFR and/or HER2 expressing cancer cell lines.

Nerlynx side effects

The most common side effects of Nerlynx in clinical trials include:

  • Diarrhea, dyspepsia, abdominal pain, decreased appetite, weight loss
  • Nausea, vomiting
  • Fatigue
  • Rash, dry skin, nail disorder, stomatitis
  • Muscle spasms
  • Urinary tract infection

In rare instances, Nerlynx can cause more serious side effects. These can include:

  • Severe Diarrhea
  • Hepatotoxicity (liver problems) – monitor liver function

A healthcare professional will assess the benefits of using Nerlynx against your risk of side effects. Patients are encouraged to report negative side effects or adverse reactions of Nerlynx to the FDA. Visit, or call 1-800-FDA-1088.

Nerlynx drug interactions

Nerlynx can interact with other medications. These include:

  • Avoid use with proton pump inhibitors (PPI) and H2-receptor antagonists – give Nerlynx 3 hours after the antacid
  • Strong or moderate CYP3A4 inhibitors
  • Strong or moderate CYP3A4 inducers – rifampin
  • The minimal concentration change of P-gp substrates may lead to serious adverse reactions when used with Nerlynx
  • Grapefruit, grapefruit juice, pomegranate, or pomegranate juice can increase the effects of Nerlynx

This list is not exhaustive and other prescription drugs may interact with Nerlynx. Talk to your healthcare advisor about all the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements.

Nerlynx contraindications

You should not use Nerlynx if you:

  • Are allergic to the active ingredient neratinib
  • Are allergic to any of the other ingredients in Nerlynx
  • Are pregnant or are planning to become pregnant – Embryo-Fetal Toxicity – you should use effective birth control (contraception) during treatment and for at least 1 month after your last dose of Nerlynx

Talk to your doctor before using Nerlynx if you:

  • Are taking any of the medications that could interact with Nerlynx
  • Are breastfeeding or are planning to breastfeed

Nerlynx generic

Nerlynx is the trademark brand name for neratinib manufactured by Puma Biotechnology, Inc. A generic version of neratinib is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Nerlynx savings through NiceRx.

Related medications

Related conditions

*Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). However, our monthly flat rate of just $49 per medication spares you the hassle of tracking the different programs and filling out all the required paperwork for each program. Subject to medication availability and acceptance by the pharmaceutical companies. NiceRx is not responsible for any delays or rejection by the pharmaceutical companies.

Enrollees enjoy a full-service solution, as NiceRx assists them and their physicians with the entire process. We prepare all required documents for the physician to sign, help enrollees manage all prescription refills, monitor eligibility criteria, and maintain enrollment.

**If you do not receive medications because you were determined to be ineligible for the prescription assistance by the applicable pharmaceutical companies and you have a letter of denial, we will refund any fees you paid toward medications for which you did not qualify to receive prescription assistance (“Refund”).

To receive a refund, you must send the letter of denial to us by fax to 888-517-7444, or by e-mail to [email protected] within 30 days of your receipt of such letter. The Refund is your sole and exclusive remedy for any fees you may wish to dispute.

The content on this website is intended for information purposes only. It does not constitute medical advice. The information on this website should not be relied upon and is not a substitute for professional medical advice. You should always speak to your doctor regarding the risks and benefits of any treatment.