Sermorelin Injection

Sermorelin is a synthetic peptide that mimics the natural growth hormone-releasing hormone (GHRH) produced by the hypothalamus. It stimulates the pituitary gland to release more growth hormone, which supports cell regeneration, metabolism, muscle growth, and overall vitality. It’s commonly used as part of anti-aging and wellness therapies and can help counteract the natural decline in growth hormone levels as we age.

A standard dosage of 0.2 mg – 0.3 mg of sermorelin injection once daily at night is typically recommended.

Sermorelin is injected subcutaneously (under the skin) of the abdomen (stomach), the outer part of the upper thigh or the upper arm, in the fatty area, usually once a day, often before bedtime.

It normally takes weeks or months of consistent use of sermorelin to start seeing benefits including increased muscle mass, improve sleep, and lower body fat.

Always use the medication as prescribed by your healthcare provider

Common side effects of sermorelin include:

• injection site reactions (pain, redness or swelling)
• flushing
• headache
• dizziness,
• nausea

The most common side effects reported are pain, redness, or swelling at the injection site. Side effects are rare and should be discussed with your healthcare provider.

Serious side effects are rare and may include

• injection site reaction (pain, redness or swelling)
• rash
• hives
• difficulty breathing
• swelling of the face, mouth, lips or tongue

Seek medical care or call 911 at once if you have the following serious side effects:

• Serious eye symptoms: sudden vision loss, tunnel vision, blurred vision, eye pain or swelling, or seeing halos around lights
• Serious heart symptoms: fast, irregular, or pounding heartbeats, shortness of breath, fluttering in your chest and sudden dizziness, lightheadedness, or passing out
• Severe headache, confusion, slurred speech, trouble walking, arm or leg weakness, feeling unsteady, loss of coordination, high fever, very stiff muscles,  profuse sweating, or tremors.

Individuals with known allergies to sermorelin or any of its ingredients, women who are pregnant or breastfeeding, and people with active cancer should not use sermorelin. People with underactive thyroid or hypothyroidism should exercise caution when using sermorelin.

Sermorelin can interact with glucocorticoids, thyroid medications (e.g. prednisone) and any other medications that could affect growth hormone levels. Tell your healthcare provider about all of your medications and conditions before starting treatment.

Sermorelin is typically considered a safe and well-tolerated medication. However, long-term use of sermorelin injection may lead to certain complications that may include:

• Injection site reactions
• Carpal tunnel syndrome
• Edema
• Insulin resistance
• Increased risk of cancer

Consult with your healthcare provider before stopping sermorelin or making any changes as they may want to titrate you off the medication gradually, monitor for withdrawal symptoms and provide supportive care as needed.  Your provider may decide to switch you to a maintenance protocol after you’ve reached optimal growth hormone levels.

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