Trulicity to Mounjaro conversion chart
Key highlights
- Mounjaro and Trulicity are both FDA-approved medications for Type 2 diabetes and are also used off-label for chronic weight management.
- Mounjaro may be more effective than Trulicity for managing blood sugar and weight loss, with up to a 2.30% reduction in HbA1c and up to 20% body weight loss, compared to 1.5% and 10% with Trulicity.
- Switching from Trulicity to Mounjaro requires a healthcare provider to adjust the dose carefully for safety and effectiveness.
- Always consult your healthcare professional before changing medications to weigh the potential benefits and risks.
Mounjaro (tirzepatide) and Trulicity (dulaglutide) are both FDA-approved GLP-1 receptor agonists made by Eli Lilly and are used to treat type 2 diabetes. They are also used off-label for weight loss.
With the growing popularity of medications like Mounjaro and Trulicity for managing type 2 diabetes, many people are exploring options that best suit their needs. Whether it’s for better blood sugar control, increased weight loss, or improved tolerability, patients may consider switching between these medications to find the most effective treatment for their health goals.
It is important to know the correct dosage when switching from Trulicity to Mounjaro because they have different strengths and effects. Accurate conversion ensures safety and that the medication will work properly for blood sugar control.
A conversion chart is a tool used by doctors to adjust doses accurately when switching medications, taking into account differences in potency, how long the drug works, and other factors that affect how the body processes the medication.
Patients transitioning between Trulicity and Mounjaro or healthcare providers adjusting treatment may need a conversion chart to ensure the correct dosage for effective management of blood sugar levels.
Learn about the key points of a conversion chart, understand what Mounjaro and Trulicity are, and follow a simple step-by-step guide to switch safely and effectively between these two medications.
What is Trulicity?
Trulicity (dulaglutide) is a once-weekly subcutaneous injectable GLP-1 agonist that helps control blood sugar levels and reduce cardiovascular risk in adults and children from 10 years of age with type 2 diabetes. Some people may also experience weight loss with it.
Trulicity has proven heart health benefits and is FDA-approved for type 2 diabetes in both adults and children as young as 10. Mounjaro is still being studied for children with type 2 diabetes, with results expected in 2025.
Trulicity is a glucagon-like peptide 1 (GLP-1) receptor agonist that helps lower blood sugar levels by mimicking a hormone called GLP-1. This helps the body release insulin, reduce sugar production, and slow down digestion (gastric emptying), leading to better glycemic control and often significant weight loss.
What is Mounjaro?
Mounjaro (tirzepatide) is a once-weekly subcutaneous injectable GLP-1/GIP receptor agonist approved by the FDA (U.S. Food and Drug Administration) in 2022 to help lower blood sugar levels in adults with type 2 diabetes. It is also prescribed off-label for weight loss when combined with diet and exercise.
Mounjaro works by activating two gut hormones: glucagon-like peptide-1 GLP-1 and glucose-dependent insulinotropic polypeptide GIP receptor in the brain and the pancreas. This helps regulate insulin after meals, controls blood sugar, slows stomach emptying, and reduces appetite, which leads to eating less and consequently losing weight.
This dual action may make Mounjaro more effective for weight management and blood glucose control than other GLP-1 medications that target only one receptor, like Ozempic and Wegovy (both manufactured by Novo Nordisk) which contain the active ingredient, semaglutide.
Tirzepatide, the active ingredient in Mounjaro, helps reduce hunger and make you feel full by affecting the hormones that control appetite. It can also help boost metabolism and burn fat.
In a study of 2,500+ adults with obesity, participants lost 15% of their body weight on a 5 mg weekly dose for 72 weeks. More weight loss was experienced with higher doses.
Why to switch from Trulicity to Mounjaro
People might switch to Mounjaro from Trulicity or vice versa because of side effects. Both medications can cause nausea, vomiting, diarrhea, indigestion, stomach pain, and constipation. If you have trouble with one, you might do better with the other.
Other reasons to switch from Trulicity to Mounjaro include:
- Improved blood sugar control: Mounjaro may provide better control over blood sugar levels than Trulicity for some people.
- Increased weight loss: Mounjaro has been shown to help with more significant weight loss, which could be beneficial for those looking to lose weight along with managing diabetes.
- Better tolerability: Some people may find Mounjaro easier to tolerate with fewer or milder side effects compared to Trulicity.
- Patient preference or individualized treatment goals: Your healthcare provider may recommend Mounjaro if it aligns better with your personal health goals and needs.
Always consult your healthcare provider before making any changes to your medication. They can provide the best advice based on your personal goals and medical history.
What is the difference between Trulicity and Mounjaro?
Mounjaro and Trulicity, both made by Eli Lilly, are effective treatments for type 2 diabetes. However, they should not be used together or with any other GLP-1 or GIP receptor agonists.
Trulicity vs. Mounjaro
| Trulicity | Mounjaro | |
|---|---|---|
| Active ingredients: | Dulaglutide | Tirzepatide |
| Mechanism of action: | GLP-1 receptor agonist that boosts insulin release. | GLP-1 and GIP receptor agonists boost insulin release, reduce hunger, and promote satiety. |
| Administration: | Once a week subcutaneously | Once a week subcutaneously |
| Efficacy: | Helps lower blood sugar and aids in weight loss | Greater reduction in HbA1c levels and more weight loss. |
| Dosage forms: | Injectable (pre-filled pen or syringe) | Injectable (pre-filled pen) |
| Available strengths: | 0.75 mg, 1.5 mg | 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg |
| Dose: | Starting dose: 0.75 mg once a week Maintenance dose: 1.5 mg once a week Maximum dose: 1.5 mg once a week | Starting dose: 2.5 mg Maintenance dose: 2.5 mg-15 mg Maximum dose: 15 mg |
| Blood sugar reduction | Reduction in HbA1C by 1.5% (on average) | Significant reduction in HbA1c up to 2.30% |
| Body weight reduction: | 5 to 10% of an individual’s total body weight. | Up to 20% of an individual’s total body weight. |
| Side effects frequency: | Nausea: 20% Diarrhea: 15% Stomach pain: 10% Headache: 5% | Nausea: 12% Diarrhea: 12% Vomiting: 9% Stomach pain: 6% Constipation: 6% |
Comparing Trulicity and Mounjaro dosage strengths for diabetes and weight loss
| Trulicity dosage | Mounjaro dosage (for diabetes) | Mounjaro dosage (for weight loss) |
|---|---|---|
| 0.75 mg | 2.5 mg | 2.5 mg |
| 1.5 mg | 5 mg | 5 mg |
| 10 mg | 10 mg | |
| 15 mg | 15 mg |
Disclaimer: This chart is for informational purposes only and should not replace medical advice. Always consult your healthcare provider for personalized recommendations for your medication and treatment plan.
Trulicity to Mounjaro conversion chart
The doses of Trulicity and Mounjaro are different, but both are typically started at a low dose and gradually increased. Mounjaro has a wider range of doses than Trulicity.
The charts below are not for direct conversions but provide general guidance for the typical doses of Mounjaro and Trulicity.
Trulicity to Mounjaro conversion chart
| Trulicity | Mounjaro | |
|---|---|---|
| Starting dose | 0.75 mg once a week | 2.5 mg once weekly for 4 weeks |
| Maintenance dose | 1.5 mg once a week | 5 mg to 12.5 mg once weekly |
| Maximum dose | 1.5 mg once a week | 15 mg once weekly |
Mounjaro to Trulicity conversion chart
| Mounjaro | Trulicity | |
|---|---|---|
| Starting dose | 2.5 mg once weekly for 4 weeks | 0.75 mg once a week |
| Maintenance dose | 5 mg to 12.5 mg once weekly | 1.5 mg once a week |
| Maximum dose | 15 mg once weekly | 1.5 mg once a week |
The conversion between Mounjaro and Trulicity isn’t exact and doses may not be exactly equivalent.
Trulicity and Mounjaro equivalent doses
| Trulicity dose | Equivalent Mounjaro dose | Notes |
|---|---|---|
| 0.75 mg | 2.5 mg | Trulicity’s lowest starting dose corresponds to Mounjaro’s starting dose. |
| 1.5 mg | 5 mg | The maximum dose of Trulicity is equivalent to the 5 mg dose of Mounjaro. |
| 1.5 mg | 10 mg | While both medications can be effective at this dose, Mounjaro's 10 mg is typically used for stronger results. |
| 1.5 mg | 15 mg | Higher doses of Mounjaro (10 mg and 15 mg) are generally not directly comparable to Trulicity’s maximum. |
When transitioning from Trulicity to Mounjaro, the starting dose of Mounjaro is higher (2.5 mg vs. 0.75 mg) because Mounjaro is stronger and works on two hormones (GLP-1/GIP), while Trulicity targets only one (GLP-1).
Your healthcare provider will look at your current dose and any side effects before deciding on the right dose for you.
A comparative chart was published in 2023 by the American Diabetes Association to help with drug shortages. This chart compares the medications based on their effects on blood sugar.
How to safely switch from Trulicity to Mounjaro
Switching from Trulicity to Mounjaro requires careful planning to ensure the change goes smoothly and that your blood sugar remains stable. Here’s a simple guide to help you switch safely.
- Consult with your healthcare provider: Always talk to your doctor before making any changes to your medication. They will guide you on how to start Mounjaro safely and may suggest a gradual dose adjustment.
- Monitor blood sugar levels: Keep track of your blood sugar levels during the switch to ensure that the new medication is working properly. Report any significant changes to your doctor.
- Consider lifestyle changes: Switching medications is only one part of managing type 2 diabetes. To get the most out of Mounjaro, make healthy lifestyle changes like eating a balanced diet, exercising regularly, and maintaining a healthy weight. These habits can help your medication work better and improve your overall health.
- Watch for side effects: Both medications have similar side effects, but Mounjaro may cause stronger side effects. You might experience stomach issues or low blood sugar symptoms like dizziness, shaking, or confusion. Contact your doctor if symptoms get worse.
How to safely switch from Trulicity to Mounjaro
| Time passed since the last dose of Trulicity | When to take the first dose of Mounjaro |
|---|---|
| Less than 7 days | Wait at least 7 days before starting Mounjaro |
| 7–14 days | You can take your first dose of Mounjaro after 7–14 days |
| 14 or more days | Today |
Factors to consider when switching
Before making any changes to your diabetes medications, talk to your healthcare provider before discontinuation of your current medications. They’ll check your overall health, including your HbA1c, weight, and other medical conditions to see if Mounjaro is right for you.
- Individualized treatment: While the conversion chart can give you general guidance on the right starting dose, your doctor may need to adjust the dosage based on factors like your health, weight, and how your body responds to the medication. This helps ensure the best results and reduces the risk of side effects.
- Medical history: Before switching from Trulicity to Mounjaro, it’s important to discuss your medical history and any current medications with your doctor. Certain health conditions or other medications you’re taking may affect how well Mounjaro works for you or increase the risk of side effects.
- Monitoring: After switching from Trulicity to Mounjaro, check your blood sugar levels closely for the first few weeks. This will help you see if the new med is working and not causing low blood sugar (hypoglycemia) or other adverse effects.
- Gradual transition: A gradual transition can be helpful when switching from Trulicity to Mounjaro, particularly if your doctor needs to increase the dosage over time. This allows your body to adjust to the new medication more comfortably and can help minimize side effects.
Side effects to monitor when switching from Trulicity to Mounjaro
Common side effects of Mounjaro include nausea, vomiting, diarrhea, stomach pain, and loss of appetite. Some people may also feel tired or have a headache.
Common side effects of Trulicity include nausea, diarrhea, stomach pain, and decreased appetite. Some people may also experience fatigue or indigestion.
Both Mounjaro and Trulicity can cause similar gastrointestinal side effects especially when you start or change the dose. When you switch to Mounjaro, these side effects may be worse.
To reduce discomfort or prevent potential adverse events:
- Start with the lower dose: Your doctor will likely begin with a lower dose to minimize side effects.
- Take the medication with food: This can help with nausea.
- Drink plenty of water: Staying hydrated helps with stomach symptoms.
Talk to your doctor if side effects are severe or last for long. They might adjust your dose or suggest other treatments.
Tips for a smooth transition
Here are some tips to make the transition from Trulicity to Mounjaro smoother:
- Keep a medication log: It’s a good idea to track your medication dosages and any side effects you may experience when switching from Trulicity to Mounjaro. This helps you notice patterns, and your healthcare provider can use this information to adjust your treatment plan if needed.
- Communication with doctor: Open communication with your healthcare provider is key during the transition. Let them know how you’re feeling, whether you’re experiencing side effects, or if you have any concerns.
- Follow-up doctor appointments: Attending follow-up appointments with your doctor is crucial to monitor your progress after switching medications. Your doctor will assess how Mounjaro is working for you, check for any potential side effects, and adjust your dose if needed.
Can you take Trulicity and Mounjaro together?
No, you should not take Trulicity and Mounjaro together. Both medications work to lower blood sugar, so using them at the same time could increase the risk factors of serious side effects like low blood sugar (hypoglycemia), pancreatitis, and injection site reactions. It is best to talk to your doctor to decide which medication should be included in your treatment plan.
Other alternatives for type 2 diabetes
Here are some injectable and oral medications that can be considered instead of Mounjaro:
- Rybelsus (oral semaglutide) is an oral GLP-1 medication taken once a day instead of being injected weekly. It can be a suitable option if you prefer not to give yourself an injection.
- Saxenda (liraglutide) was the first GLP-1 medication approved for weight loss in adults with obesity or overweight with at least one weight-related health issue. It is also approved for certain children 12 and older with obesity.
- Victoza (liraglutide) is another injectable GLP-1 agonist approved for type 2 diabetes, but it needs to be injected once a day instead of once a week because it doesn’t stay in the body as long as Mounjaro and other alternatives.
- Byetta (exenatide) was the first GLP-1 agonist approved by the FDA. It needs to be injected twice a day, no more than an hour before meals, which may be helpful if your blood sugar rises after eating.
- Bydureon BCise is a longer-lasting version of Byetta and only needs to be injected once a week, like many other Mounjaro alternatives. Bydureon BCise is approved for adults and children aged 10 and older, while Byetta is only approved for adults.
- Metformin lowers blood sugar in people with diabetes mellitus by increasing insulin sensitivity and reducing sugar made in the liver. It’s an inexpensive alternative available at most pharmacies.
Frequently asked questions
Can I switch directly from Trulicity to Mounjaro?
Yes, you can switch from Trulicity to Mounjaro, but it should be done under your healthcare provider’s supervision. They can guide you on the best way to transition between the medications.
Is there a generic version of Mounjaro?
No, there is currently no generic version of Mounjaro available. You will need to use the brand-name version or you can consider compounded tirzepatide, which contains the same active ingredient as Mounjaro and Zepbound.
Is Mounjaro more effective than Trulicity for weight loss?
Mounjaro may be more effective than Trulicity for weight loss based on clinical trials. However, results can vary, so it’s best to discuss which medication is right for you with your doctor.
How long does it take to see results after switching to Mounjaro?
You may start to see results with Mounjaro in a few weeks, although it can take a couple of months for the full effect. The maximum benefits are realized over a longer time and the medication is intended to be used long-term. The exact timeline can vary from person to person.
Are there any cost differences between Trulicity and Mounjaro?
Mounjaro typically costs more than Trulicity. The cost can vary depending on your insurance and where you buy the medication from. Mounjaro costs about $1,100 per month and Trulicity costs about $1,000 per month.
What are the most common side effects of Mounjaro?
The most common side effects of Mounjaro include nausea, vomiting, diarrhea, and upset stomach. Some people may also experience a decrease in appetite or headache.
Can I switch back to Trulicity if Mounjaro doesn’t work for me?
Yes, you can switch back to Trulicity if Mounjaro doesn’t work for you. It’s important to talk to your healthcare provider about the best plan for making the switch safely.
Bottom line
Switching from Trulicity to Mounjaro means better blood sugar control and more weight loss. Mounjaro has more a1c reduction and up to 20% weight loss.
Use a conversion chart with the supervision of your healthcare provider to adjust the Mounjaro dose based on your current Trulicity dose for safe and effective treatment.
Make healthy lifestyle changes like eating well and increasing physical activity to make your treatment more effective.
Close monitoring of blood glucose and side effects is key during the switch and working with your healthcare provider will make the transition smooth for better weight loss and diabetes care.
